Silencing Gene‐Engineered Injectable Hydrogel Microsphere for Regulation of Extracellular Matrix Metabolism Balance

Small Methods ◽  
2022 ◽  
pp. 2101201
Author(s):  
Hongze Chang ◽  
Feng Cai ◽  
Yan Zhang ◽  
Mingwei Jiang ◽  
Xiaolong Yang ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Injectable Hydrogel ◽  
Hydrogel Microsphere ◽  
Matrix Metabolism

scholarly journals Connective Tissue Metabolism and Gingival Overgrowth

2004 ◽  
Vol 15 (3) ◽  
pp. 165-175 ◽  
Author(s):  
P. C. Trackman ◽  
A. Kantarci
Keyword(s):  
Extracellular Matrix ◽  
Connective Tissue ◽  
Oral Hygiene ◽  
Tissue Specificity ◽  
Gingival Fibroblast ◽  
Drug Induced ◽  
Gingival Overgrowth ◽  
Connective Tissue Metabolism ◽  
Matrix Metabolism ◽  
Systemic Health

Gingival overgrowth occurs mainly as a result of certain anti-seizure, immunosuppressive, or antihypertensive drug therapies. Excess gingival tissues impede oral function and are disfiguring. Effective oral hygiene is compromised in the presence of gingival overgrowth, and it is now recognized that this may have negative implications for the systemic health of affected patients. Recent studies indicate that cytokine balances are abnormal in drug-induced forms of gingival overgrowth. Data supporting molecular and cellular characteristics that distinguish different forms of gingival overgrowth are summarized, and aspects of gingival fibroblast extracellular matrix metabolism that are unique to gingival tissues and cells are reviewed. Abnormal cytokine balances derived principally from lymphocytes and macrophages, and unique aspects of gingival extracellular matrix metabolism, are elements of a working model presented to facilitate our gaining a better understanding of mechanisms and of the tissue specificity of gingival overgrowth.

scholarly journals Signaling Mechanisms in the Regulation of Renal Matrix Metabolism in Diabetes

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Meenalakshmi M. Mariappan
Keyword(s):  
Extracellular Matrix ◽  
Signaling Pathways ◽  
Matrix Protein ◽  
Structural Changes ◽  
Mammalian Target Of Rapamycin ◽  
Adverse Outcomes ◽  
Matrix Proteins ◽  
Extracellular Matrix Protein ◽  
Renal Hypertrophy ◽  
Matrix Metabolism

Renal hypertrophy and accumulation of extracellular matrix proteins are among cardinal manifestations of diabetic nephropathy. TGF beta system has been implicated in the pathogenesis of these manifestations. Among signaling pathways activated in the kidney in diabetes, mTOR- (mammalian target of rapamycin-)regulated pathways are pivotal in orchestrating high glucose-induced production of ECM proteins leading to functional and structural changes in the kidney culminating in adverse outcomes. Understanding signaling pathways that influence individual matrix protein expression could lead to the development of new interventional strategies. This paper will highlight some of the diverse components of the signaling network stimulated by hyperglycemia with an emphasis on extracellular matrix protein metabolism in the kidney in diabetes.

Hypoxia-Induced Changes in Extracellular Matrix Metabolism in Renal Cells

1999 ◽  
Vol 7 (5-6) ◽  
pp. 463-469 ◽  
Author(s):  
J.T. Norman ◽  
C. Orphanides ◽  
P. Garcia ◽  
L.G. Fine
Keyword(s):  
Extracellular Matrix ◽  
Renal Cells ◽  
Matrix Metabolism ◽  
Induced Changes

scholarly journals Extracellular matrix metabolism disorder induced by mechanical strain on human parametrial ligament fibroblasts

2017 ◽  
Vol 15 (5) ◽  
pp. 3278-3284 ◽  
Author(s):  
Jie Min ◽  
Bingshu Li ◽  
Cheng Liu ◽  
Wenjun Guo ◽  
Shasha Hong ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Mechanical Strain ◽  
Metabolism Disorder ◽  
Matrix Metabolism

Synergistically regulated spontaneous calcium signaling is attributed to cartilaginous extracellular matrix metabolism

2018 ◽  
Vol 234 (6) ◽  
pp. 9711-9722 ◽  
Author(s):  
Xiaoyuan Gong ◽  
Gaoming Li ◽  
Yang Huang ◽  
Zhenlan Fu ◽  
Xiongbo Song ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Calcium Signaling ◽  
Matrix Metabolism

Injectable Hydrogel–Microsphere Construct with Sequential Degradation for Locally Synergistic Chemotherapy

2017 ◽  
Vol 9 (4) ◽  
pp. 3487-3496 ◽  
Author(s):  
Yuhao Zheng ◽  
Yilong Cheng ◽  
Jinjin Chen ◽  
Jianxun Ding ◽  
Mingqiang Li ◽  
...  
Keyword(s):  
Injectable Hydrogel ◽  
Hydrogel Microsphere

Cytotoxicity of three commercial mouthrinses on extracellular matrix metabolism and human gingival cell behaviour

2016 ◽  
Vol 34 ◽  
pp. 88-96 ◽  
Author(s):  
Stefania Balloni ◽  
Paola Locci ◽  
Alessandro Lumare ◽  
Lorella Marinucci
Keyword(s):  
Extracellular Matrix ◽  
Cell Behaviour ◽  
Matrix Metabolism
Sign in / Sign up

Export Citation Format

Share Document