scholarly journals TGF‐β1‐activated type 2 dendritic cells promote wound healing and induce fibroblasts to express tenascin c following corneal full‐thickness hydrogel transplantation

2019 ◽  
Vol 13 (9) ◽  
pp. 1507-1517 ◽  
Author(s):  
Christine Mölzer ◽  
Sucharita P. Shankar ◽  
Vlad Masalski ◽  
May Griffith ◽  
Lucia Kuffová ◽  
...  
Keyword(s):  
Wound Healing ◽  
Dendritic Cells ◽  
Full Thickness ◽  
Promote Wound Healing ◽  
Tenascin C ◽  
Tgf Β1

Study on the Effect of Cerium Oxide Nanocubes on Full-Thickness Cutaneous Wound Healing of Type 2 Diabetic Rats

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 643-P ◽  
Author(s):  
YANFEI HAN ◽  
LINDONG LI ◽  
YANJUN LIU ◽  
YOU WANG ◽  
CHUNHUA YAN ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cerium Oxide ◽  
Diabetic Rats ◽  
Cutaneous Wound Healing ◽  
Full Thickness ◽  
Cutaneous Wound ◽  
Type 2 Diabetic

Melittin and diclofenac synergistically promote wound healing in a pathway involving TGF-β1

2021 ◽  
pp. 105993
Author(s):  
Basma G. Eid ◽  
Nabil A. Alhakamy ◽  
Usama A. Fahmy ◽  
Osama A.A. Ahmed ◽  
Shadab Md ◽  
...  
Keyword(s):  
Wound Healing ◽  
Promote Wound Healing ◽  
Tgf Β1

Locally Applied Mononuclear Bone Marrow Cells Restore Angiogenesis and Promote Wound Healing in a Type 2 Diabetic Patient

2005 ◽  
Vol 113 (09) ◽  
pp. 538-540 ◽  
Author(s):  
P. Humpert ◽  
U. Bärtsch ◽  
I. Konrade ◽  
H.-P. Hammes ◽  
M. Morcos ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Wound Healing ◽  
Diabetic Patient ◽  
Bone Marrow Cells ◽  
Promote Wound Healing ◽  
Type 2 Diabetic ◽  
Mononuclear Bone Marrow Cells ◽  
Marrow Cells

scholarly journals Nocardia rubra cell wall skeleton accelerates cutaneous wound healing by enhancing macrophage activation and angiogenesis

2018 ◽  
Vol 46 (6) ◽  
pp. 2398-2409 ◽  
Author(s):  
Yi Wang ◽  
Ying Hu ◽  
Ben Ma ◽  
Fei Wang ◽  
Sheng Liu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cell Wall ◽  
Transforming Growth Factor ◽  
Wound Dressings ◽  
Control Group ◽  
Cutaneous Wound Healing ◽  
Full Thickness ◽  
Cutaneous Wound ◽  
Expression Levels ◽  
Tgf Β1

Objective This study was performed to investigate the effect of Nocardia rubra cell wall skeleton (N-CWS) on wound healing of full-thickness skin defects. Methods Two 2- × 2-cm full-thickness wounds, one on each side of the midline, were made on the back of 12 rats. One wound was covered with Vaseline gauze soaked in normal saline, whereas the other was covered with Vaseline gauze and N-CWS. Wound dressings were changed every other day from day 0 (wound creation) to day 11. Four of the 12 rats were killed on day 7, and biopsy samples were obtained for biochemical and histopathological analyses. The expression levels of CD31, CD68, and F4/80 in the tissues were examined immunohistologically. The expression of transforming growth factor (TGF)-β1 in the wound was determined by western blot. Results N-CWS increased the wound healing rate, reduced the complete wound healing time, and increased the expression levels of CD31, CD68, and F4/80 on day 7. The TGF-β1 expression level in the wound was significantly higher in the N-CWS group than in the control group on day 7. Conclusions N-CWS can activate macrophages, increase TGF-β1 expression, and enhance angiogenesis and thus accelerate cutaneous wound healing.

scholarly journals Keladi candik (Alocasia longiloba Miq.) petiole extracts promote wound healing in a full thickness excision wound model in rats

2019 ◽  
Vol 9 (4) ◽  
pp. 140 ◽  
Author(s):  
Arifullah Mohammed ◽  
KNS Sirajudeen ◽  
NurulHazirah Che Hamzah ◽  
MohdAsnizam Asari ◽  
Zulhazman Hamzah ◽  
...  
Keyword(s):  
Wound Healing ◽  
Full Thickness ◽  
Excision Wound ◽  
Promote Wound Healing ◽  
Wound Model ◽  
Full Thickness Excision

Reduction of peripheral blood dendritic cells and their subsets in type 2 diabetes patients

2006 ◽  
Vol 114 (S 1) ◽  
Author(s):  
C Summerer ◽  
K Trübenbach ◽  
I Harsch ◽  
C Seifarth
Keyword(s):  
Type 2 Diabetes ◽  
Dendritic Cells ◽  
Peripheral Blood ◽  
Diabetes Patients

591-P: Macrophage IL-1beta–Dependent VEGF-A Expression Is Required for Inflammatory Arteriogenesis and Wound Healing in Type 2 Diabetes

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 591-P
Author(s):  
CHRIS S. MANTSOUNGA
Keyword(s):  
Type 2 Diabetes ◽  
Wound Healing

The Safety and Efficacy of Mupirocin Topical Spray for Burn Wound Healing in A Rat Model

2019 ◽  
Vol 10 (01) ◽  
Author(s):  
Sritharadol Rutthapol ◽  
Chunhachaichana Charisopon ◽  
Kumlungmak Sukanjana ◽  
Buatong Wilaiporn ◽  
Dechraksa Janwit ◽  
...  
Keyword(s):  
Wound Healing ◽  
Matrix Metalloproteinase ◽  
Rat Model ◽  
Transforming Growth Factor ◽  
Immunohistochemical Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Burn Wound ◽  
Safety And Efficacy ◽  
Burn Wound Healing ◽  
Tgf Β1

ABSTRACT This study evaluated the effect of mupirocin topical spray on burn wound healing in a rat model. Fifteen male Sprague Dawley rats were used to create full-thickness burns on the rat dorsum using a cylindrical stainless steel rod. The rats were topically treated with normal saline solution (NSS), mupirocin spray, ointment, and solution. The wound size and morphological evaluation were investigated by photographs and clinical criterions for wound healing. The histology was observed by hematoxylin and eosin (HandE) staining assay. The immunohistochemical study was evaluated by detection of transforming growth factor-beta 1 (TGF-β1), and the ratio of matrix metalloproteinase-9 to the tissue inhibitor of matrix metalloproteinase-1 (MMP-9/TIMP-1) was quantified using the enzyme-linked immunosorbent assay (ELISA) assay. A complete healing was observed at 28 days in all treatments. Mupirocin formulations accelerated the wound healing faster than NSS in size. However, the clinical criteria indicated a desirable skin appearance in the mupirocin spray and ointment treated groups. The histological evaluations showed no differences between the treatments while the immunohistochemical study revealed that all treatments reduced the level of TGF-β1 over time, particularly on day 28 in the mupirocin spray and ointment treated groups. The MMP-9/TIMP-1 ratio was significantly lower in the mupirocin spray and ointment treated groups than in the NSS and mupirocin solution groups. This study shows the safety and efficacy in the use of mupirocin topical spray. The topical mupirocin spray is an alternative suitable for development as a human topical anti-infective and wound protection spray.

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