The crude extract ofCorni Fructusinduces apoptotic cell death through reactive oxygen species-modulated pathways in U-2 OS human osteosarcoma cells

2012 ◽  
Vol 29 (9) ◽  
pp. 1020-1031 ◽  
Author(s):  
Ching-Lung Liao ◽  
Shu-Chun Hsu ◽  
Chien-Chih Yu ◽  
Jai-Sing Yang ◽  
Nou-Ying Tang ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Crude Extract ◽  
Apoptotic Cell ◽  
Reactive Oxygen ◽  
Apoptotic Cell Death ◽  
Oxygen Species ◽  
Osteosarcoma Cells ◽  
Human Osteosarcoma ◽  
Human Osteosarcoma Cells

scholarly journals cis-Urocanic Acid Enhances Prostaglandin E2 Release and Apoptotic Cell Death via Reactive Oxygen Species in Human Keratinocytes

2011 ◽  
Vol 131 (6) ◽  
pp. 1262-1271 ◽  
Author(s):  
Kazuyo Kaneko ◽  
Susan L. Walker ◽  
Joey Lai-Cheong ◽  
Mary S. Matsui ◽  
Mary Norval ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Prostaglandin E2 ◽  
Apoptotic Cell ◽  
Reactive Oxygen ◽  
Human Keratinocytes ◽  
Urocanic Acid ◽  
Apoptotic Cell Death ◽  
Oxygen Species

scholarly journals Green-Synthesized Silver Nanoparticles Induced Apoptotic Cell Death in MCF-7 Breast Cancer Cells by Generating Reactive Oxygen Species and Activating Caspase 3 and 9 Enzyme Activities

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Ikram Ullah ◽  
Ali Talha Khalil ◽  
Muhammad Ali ◽  
Javed Iqbal ◽  
Waqar Ali ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Silver Nanoparticles ◽  
Cell Death ◽  
Apoptotic Cell ◽  
Morphological Changes ◽  
Reactive Oxygen ◽  
Apoptotic Cell Death ◽  
Oxygen Species ◽  
Cell Viability Assay ◽  
Mcf 7

Silver nanoparticles are among the most significant diagnostic and therapeutic agents in the field of nanomedicines. In the current study, the green chemistry approach was made to optimize a cost-effective synthesis protocol for silver nanoparticles from the aqueous extract of the important anticancer plant Fagonia indica. We investigated the anticancer potential and possible involvement of AgNPs in apoptosis. The biosynthesized AgNPs are stable (zeta potential, -16.3 mV) and spherical with a crystal size range from 10 to 60 nm. The MTT cell viability assay shows concentration-dependent inhibition of the growth of Michigan Cancer Foundation-7 (MCF-7) cells (IC50, 12.35 μg/mL). In addition, the fluorescent microscopic analysis shows activation of caspases 3 and 9 by AgNPs that cause morphological changes (AO/EB assay) in the cell membrane and cause nuclear condensation (DAPI assay) that eventually lead to apoptotic cell death (Annexin V/PI assay). It was also observed that AgNPs generate reactive oxygen species (ROS) that modulate oxidative stress in MCF-7 cells. This is the first study that reports the synthesis of a silver nanoparticle mediated by Fagonia indica extract and evaluation of the cellular and molecular mechanism of apoptosis.

scholarly journals Silibinin Induced Autophagic and Apoptotic Cell Death in HT1080 Cells Through a Reactive Oxygen Species Pathway

2010 ◽  
Vol 113 (1) ◽  
pp. 48-56 ◽  
Author(s):  
Wenjun Duan ◽  
Xiaoying Jin ◽  
Qisheng Li ◽  
Shin-ichi Tashiro ◽  
Satoshi Onodera ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Apoptotic Cell ◽  
Reactive Oxygen ◽  
Apoptotic Cell Death ◽  
Oxygen Species ◽  
Ht1080 Cells

scholarly journals Death Receptors 4 and 5 Activate Nox1 NADPH Oxidase through Riboflavin Kinase to Induce Reactive Oxygen Species-mediated Apoptotic Cell Death

2011 ◽  
Vol 287 (5) ◽  
pp. 3313-3325 ◽  
Author(s):  
Kyung-Jin Park ◽  
Chang-Han Lee ◽  
Aeyung Kim ◽  
Ki Jun Jeong ◽  
Chul-Ho Kim ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Nadph Oxidase ◽  
Apoptotic Cell ◽  
Reactive Oxygen ◽  
Death Receptors ◽  
Apoptotic Cell Death ◽  
Oxygen Species

scholarly journals Reactive oxygen species induced by Streptococcus pyogenes invasion trigger apoptotic cell death in infected epithelial cells

2010 ◽  
Vol 12 (6) ◽  
pp. 814-830 ◽  
Author(s):  
Chihiro Aikawa ◽  
Takashi Nozawa ◽  
Fumito Maruyama ◽  
Kohei Tsumoto ◽  
Shigeyuki Hamada ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Epithelial Cells ◽  
Streptococcus Pyogenes ◽  
Apoptotic Cell ◽  
Reactive Oxygen ◽  
Apoptotic Cell Death ◽  
Oxygen Species
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