Potential anti-inflammatory and antioxidant effects of Citrus aurantium essential oil against carbon tetrachloride-mediated hepatotoxicity: A biochemical, molecular and histopathological changes in adult rats

2018 ◽  
Vol 34 (4) ◽  
pp. 388-400 ◽  
Author(s):  
Anis Ben Hsouna ◽  
Manel Gargouri ◽  
Wissal Dhifi ◽  
Rania Ben Saad ◽  
Naima Sayahi ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Essential Oil ◽  
Citrus Aurantium ◽  
Histopathological Changes ◽  
Adult Rats ◽  
Anti Inflammatory ◽  
Antioxidant Effects

Topical anti-inflammatory, gastroprotective and antioxidant effects of the essential oil of Lippia sidoides Cham. leaves

2007 ◽  
Vol 111 (2) ◽  
pp. 378-382 ◽  
Author(s):  
Maria Vivina Barros Monteiro ◽  
Ana Karine Rocha de Melo Leite ◽  
Luciana Medeiros Bertini ◽  
Selene Maia de Morais ◽  
Diana Célia Sousa Nunes-Pinheiro
Keyword(s):  
Essential Oil ◽  
Lippia Sidoides ◽  
Anti Inflammatory ◽  
Antioxidant Effects

Skład chemiczny i właściwości biologiczne Geum urbanum L. – aktualny stan badań

2019 ◽  
Vol 20 (3) ◽  
Author(s):  
Izabela Czapska-Pietrzak ◽  
Elżbieta Studzińska-Sroka ◽  
Wiesława Bylka
Keyword(s):  
Essential Oil ◽  
Folk Medicine ◽  
Perennial Herb ◽  
Liver Disorders ◽  
Rosaceae Family ◽  
Anti Inflammatory ◽  
Antioxidant Effects ◽  
Geum Urbanum

Geum urbanum L. (St. Benedict’s herb, Wood Avens) belonging to Rosaceae family, is a perennial herb occuring in the moderate zone of both Hemispheres. The roots and rhizomes containing: tannins, especially ellagitannins (mainly gemin), essential oil (mainly gein), flavonoids, proanthocyanidins, triterpenes, carbohydrates. In folk medicine it was used in gastro-enteritis and liver disorders, and to induce cardiogenesis also externally for reducing the gingivitis. The results of experiments on: antimicrobial, anti-inflammatory, cardiogenic and antioxidant effects were presented.

Evaluation of Anti-inflammatory and Antioxidant Effects of Sumatriptan on Carbon Tetrachloride-induced Hepatotoxicity in Rats

Drug Research ◽  
2021 ◽  
Author(s):  
Ahmad Reza Dehpour ◽  
Hasan Yousefi-Manesh ◽  
Mohammad Sheibani ◽  
Mohammad Amin Sadeghi ◽  
Sara Hemmati ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Histopathological Examination ◽  
Serum Levels ◽  
Control Group ◽  
Adult Rats ◽  
Toxic Agents ◽  
Tnf Α ◽  
Anti Oxidant ◽  
Anti Inflammatory ◽  
Pre Treatment

AbstractThe liver detoxifies and metabolizes many drugs and xenobiotics which may cause hepatotoxicity due to some toxic agents. Carbon tetrachloride (CCl4) is metabolized in cytochrome P450 and its reactive radical metabolites cause lipid peroxidation, cellular injury, and apoptosis. Sumatriptan (SUM), 5-HT1B/1D receptor agonist, had anti-inflammatory and anti-oxidant effects. In this research the effect of SUM pre-treatment against CCl4-induced hepatotoxicity was examined. Adult rats received SUM (0.1, 0.3 and 1 mg/kg; i.p.) for 3 consecutive days before CCl4 (2 ml/kg; i.p. on the 3rd day). The aminotransferases serum levels, tissue levels of anti-oxidant and pro-inflammatory markers and histopathological examination were evaluated. SUM (0.3 mg/kg) prevented significantly the elevation of aminotransferases versus the control group (CCl4 group) (P<0.0001) and also, reversed meaningfully the changes of the MPO, MDA, SOD and CAT, IL-1β and TNF-α levels. Additionally, CCl4-intoxication resulted to the disruption of lobular and cellular structures and inflammation in histopathological evaluation which is prevented by SUM (0.3 mg/kg). These data revealed that SUM (0.3 mg/kg), but no at doses 0.1 and 1 mg/kg, decreases the hepatotoxicity of induced by CCl4 in rats.

scholarly journals The anti-inflammatory and antioxidant effects of rosa damascena mill. essential oil on the lung injury in the CLP model

2020 ◽  
Vol 19 (74) ◽  
pp. 277-294
Author(s):  
Abolfazl Dadkhah ◽  
Faezeh Fatemi ◽  
Mohammad Reza Mohammadi Malayeri ◽  
Mohammad Hassan Karvin Ashtiani ◽  
Zahra Mosavi ◽  
...  
Keyword(s):  
Essential Oil ◽  
Lung Injury ◽  
Rosa Damascena ◽  
Anti Inflammatory ◽  
Antioxidant Effects

Antifungal and anti-inflammatory claims for wild carrot essential oil

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
J Valente ◽  
R Resende ◽  
M Zuzarte ◽  
MJ Gonçalves ◽  
MC Lopes ◽  
...  
Keyword(s):  
Essential Oil ◽  
Wild Carrot ◽  
Anti Inflammatory

Effect of essential oil of Citrus cinensis cv new hall – Citrus aurantium (indigenous in Greece) upon growth of Yarrowia lipolytica

Planta Medica ◽  
2006 ◽  
Vol 72 (11) ◽  
Author(s):  
O Gortzi ◽  
S Papanikolaou ◽  
S Lalas ◽  
M Galiotou-Panayotou ◽  
P Mitliaga
Keyword(s):  
Essential Oil ◽  
Yarrowia Lipolytica ◽  
Citrus Aurantium

Therapeutic Effects of Milk Thistle Extract against Renal Toxicity Induced By Diethylnitrosamine and Carbon Tetrachloride in Adult Rats

2017 ◽  
Vol 10 (1) ◽  
pp. 107-124
Author(s):  
Amal. Ahmed ◽  
Abeer Hassanin ◽  
Abeer Hassan ◽  
Saadia Ali ◽  
A. El-Anwar
Keyword(s):  
Carbon Tetrachloride ◽  
Renal Toxicity ◽  
Milk Thistle ◽  
Therapeutic Effects ◽  
Adult Rats

Comparative Analysis of In-Vitro Biological Activities of Methyl Eugenol Rich Cymbopogon khasianus Hack., Leaf Essential Oil with Pure Methyl Eugenol Compound

2020 ◽  
Vol 21 (10) ◽  
pp. 927-938 ◽  
Author(s):  
Roktim Gogoi ◽  
Rikraj Loying ◽  
Neelav Sarma ◽  
Twahira Begum ◽  
Sudin K. Pandey ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Biological Activities ◽  
Methyl Eugenol ◽  
Dpph Assay ◽  
Pure Compound ◽  
Allium Cepa Assay ◽  
Anti Inflammatory ◽  
Lemongrass Essential Oil

Background: The essential oil of methyl eugenol rich Cymbopogon khasianus Hack. was evaluated and its bioactivities were compared with pure methyl eugenol. So far, methyl eugenol rich essential oil of lemongrass was not studied for any biological activities; hence, the present study was conducted. Objective: This study examined the chemical composition of essential oil of methyl eugenol rich Cymbopogon khasianus Hack., and evaluated its antioxidant, anti-inflammatory, antimicrobial, and herbicidal properties and genotoxicity, which were compared with pure compound, methyl eugenol. Material and Methods: Methyl eugenol rich variety of Cymbopogon khasianus Hack., with registration no. INGR18037 (c.v. Jor Lab L-9) was collected from experimental farm CSIR-NEIST, Jorhat, Assam (26.7378°N, 94.1570°E). The essential oil wasobtained by hydro-distillation using a Clevenger apparatus. The chemical composition of the essential oil was evaluated using GC/MS analysis and its antioxidant (DPPH assay, reducing power assay), anti-inflammatory (Egg albumin denaturation assay), and antimicrobial (Disc diffusion assay, MIC) properties, seed germination effect and genotoxicity (Allium cepa assay) were studied and compared with pure Methyl Eugenol compound (ME). Results: Major components detected in the Essential Oil (EO) through Gas chromatography/mass spectroscopy analysis were methyl eugenol (73.17%) and β-myrcene (8.58%). A total of 35components were detected with a total identified area percentage of 98.34%. DPPH assay revealed considerable antioxidant activity of methyl eugenol rich lemongrass essential oil (IC50= 2.263 μg/mL), which is lower than standard ascorbic acid (IC50 2.58 μg/mL), and higher than standard Methyl Eugenol (ME) (IC50 2.253 μg/mL). Methyl eugenol rich lemongrass EO showed IC50 38.00 μg/mL, ME 36.44 μg/mL, and sodium diclofenac 22.76 μg/mL, in in-vitro anti-inflammatory test. Moderate antimicrobial activity towards the 8 tested microbes was shown by methyl eugenol rich lemongrass essential oil whose effectiveness against the microbes was less as compared to pure ME standard. Seed germination assay further revealed the herbicidal properties of methyl eugenol rich essential oil. Moreover, Allium cepa assay revealed moderate genotoxicity of the essential oil. Conclusion: This paper compared the antioxidant, anti-inflammatory, antimicrobial, genotoxicity and herbicidal activities of methyl eugenol rich lemongrass with pure methyl eugenol. This methyl eugenol rich lemongrass variety can be used as an alternative of methyl eugenol pure compound. Hence, the essential oil of this variety has the potential of developing cost-effective, easily available antioxidative/ antimicrobial drugs but its use should be under the safety range of methyl eugenol and needs further clinical trials.

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