Changes in peak oxygen uptake (VO 2peak ) following renal transplant: Results after 3‐year follow‐up

2021 ◽  
Author(s):  
Siddhartha S. Angadi ◽  
Cody M. Bushroe ◽  
Harini A. Chakkera
Keyword(s):  
Renal Transplant ◽  
Oxygen Uptake ◽  
Peak Oxygen Uptake

scholarly journals Does Pseudomonas aeruginosa Colonization Affect Exercise Capacity in CF?

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Asterios Kampouras ◽  
Elpis Hatziagorou ◽  
Vasiliki Avramidou ◽  
Vasiliki Georgopoulou ◽  
Fotios Kirvassilis ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Oxygen Uptake ◽  
Exercise Capacity ◽  
Peak Oxygen Uptake ◽  
Exercise Intolerance ◽  
High Resolution Computed Tomography ◽  
Exercise Limitation ◽  
Multiple Breath Washout ◽  
Colonization Status

Introduction. Cardio-Pulmonary Exercise Testing (CPET) has been recognized as a valuable method in assessing disease burden and exercise capacity among CF patients. Aim. To evaluate whether Pseudomonas aeruginosa colonization status affects Exercise Capacity, LCI and High-Resolution Computed Tomography (HRCT) indices among patients with CF; to check if Pseudomonas colonization can predict exercise intolerance. Subjects. Seventy-eight (78) children and adults with CF (31 males) mean (range) age 17.08 (6.75; 24.25) performed spirometry, Multiple Breath Washout (MBW) and CPET along with HRCT on the same day during their admission or follow up visit. Results. 78 CF patients (mean FEV1: 83.3% mean LCI: 10.9 and mean VO2 peak: 79.1%) were evaluated: 33 were chronically colonized with Pseudomonas aeruginosa, 24 were intermittently colonized whereas 21 were Pseudomonas free. Statistically significant differences were observed among the three groups in: peak oxygen uptake % predicted (VO2 peak% (p<0.001), LCI (p<0.001), as well as FEV1% (p<0.001) and FVC% (p<0.001). Pseudomonas colonization could predict VO2 peak% (p<0.001, r2: −0.395). Conclusion. Exercise capacity as reflected by peak oxygen uptake is reduced in Pseudomonas colonized patients and reflects lung structural damages as shown on HRCT. Pseudomonas colonization could predict exercise limitation among CF patients.

Abstract 16182: Prognostic Value of Peak Oxygen Uptake Trajectories for Mortality Risk in Patients With Heart Failure

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Emily Mansour ◽  
chao cao ◽  
Alyssa Purtiz ◽  
Qiaonan Zhong ◽  
Andrea Soares ◽  
...  
Keyword(s):  
Heart Failure ◽  
Mortality Rate ◽  
Oxygen Uptake ◽  
Mortality Risk ◽  
Prognostic Value ◽  
Peak Oxygen Uptake ◽  
Cardiovascular Fitness ◽  
Lower Mortality ◽  
Social Security Death Index

Introduction: Peak oxygen uptake (VO 2peak ), as determined by cardiopulmonary exercise testing (CPET), is informative of cardiovascular fitness and heart failure (HF) disease progression. Due to their clinical meaningfulness, many patients with HF undergo multiple CPETs throughout their lifetimes. However, a gap in knowledge exists regarding the prognostic value of longitudinal changes in VO 2peak for mortality risk. The aim of this study was to investigate whether VO 2peak trajectories are predictive of mortality among patients with HF. Methods: Patients with HF who completed two CPETs (separated by at least 3 months, mean = 25.3 months) at Washington University School of Medicine between May 1993 and February 2020 were included in the study. Vital statuses and mortality dates were collected from May 2019 to May 2020 via electronic health records and the Social Security Death Index. Kaplan-Meier and Cox proportional hazards regression analyses were used to evaluate associations between changes in VO 2peak and mortality. Results: The sample included 162 patients with a mean age of 48.5 years (SD 10.5) at baseline. VO 2peak averaged 18.1 (SD 4.9) ml·kg -1 ·min -1 in 121 men and 15.1 (SD 4.1) ml·kg -1 ·min -1 in 41 women. During a median follow-up of 11.8 years (range 1-23 years), 70 patients died. A significant negative association between VO 2peak and mortality was observed (hazard ratio [HR] = 0.92; 95% Confidence Interval [CI] = 0.87 to 0.98; P = 0.011). Patients whose VO 2peak increased from their baseline to second CPET had higher survival rates compared to patients whose VO 2peak decreased. Moreover, the annual rate of change in VO 2peak was associated with mortality rates. A 9% lower mortality rate was observed for each unit increase in VO 2peak change (i.e., 1 ml·kg -1 ·min -1 ) for the entire follow-up period (HR = 0.91; 95% CI = 0.85 to 0.97) and at 10-year follow-up (HR = 0.91; 95% CI = 0.85 to 0.98), while a 12% lower mortality rate was observed at 5-year follow-up (HR = 0.88, 95% CI = 0.78 to 1.00) relative to baseline CPETs. Conclusion: Increases in VO 2peak were associated with increased survival rate among patients with HF. These findings highlight the importance of promoting exercise and cardiac rehabilitation for patients with HF.

A pilot program for physical exercise promotion in adults with type 1 diabetes: the PEP-1 program

2014 ◽  
Vol 39 (4) ◽  
pp. 465-471 ◽  
Author(s):  
Anne-Sophie Brazeau ◽  
Véronique Gingras ◽  
Catherine Leroux ◽  
Corinne Suppère ◽  
Hortensia Mircescu ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Physical Exercise ◽  
Oxygen Uptake ◽  
Physical Inactivity ◽  
Peak Oxygen Uptake ◽  
Control Group ◽  
Pilot Program ◽  
Exercise Promotion

Physical inactivity is highly common in adults with type 1 diabetes (T1D) as specific barriers (i.e., hypoglycemia) may prevent them from being active. The objective of this study was to examine the efficacy of the Physical Exercise Promotion program in type 1 diabetes (PEP-1) program, a group program of physical activity (PA) promotion (intervention) compared with an information leaflet (control), to improve total energy expenditure (TEE) in adults with T1D after 12 weeks. TEE was measured with a motion sensor over a 7-day period at inclusion, after the program (12 weeks) and 1-year after inclusion. The 12 weekly sessions of the program included a 30-min information session (glycemic control and PA) and 60 min of PA. A total of 48 adults, aged 18 to 65 years with a reported PA practice <150 min per week, were recruited (45.8% men; aged 44.6 ± 13.3 years; 8.0% ± 1.1% glycated hemoglobin (A1c)) and randomized in this pilot trial. Ninety percent of participants completed the program and 88% completed the 1-year follow-up. No change was observed for TEE and A1c in both groups. After the 12-week program, the mean peak oxygen uptake increased (14%; p = 0.003) in the intervention group; however, at the 1-year follow-up, it was no longer different from baseline. In the control group, no difference was observed for the peak oxygen uptake. These results suggest that the PEP-1 pilot program could increase cardiorespiratory fitness. However, this benefit is not sustained over a long-term period. The PEP-1 program did not increase TEE in patients with T1D and other strategies remain necessary to counteract physical inactivity in this population.

The feasibility of a newly developed local network system for cardiac rehabilitation (the CR-GNet) in disease management and physical fitness after acute coronary syndrome

2021 ◽  
Vol 28 (Supplement_1) ◽  
Author(s):  
T Ando ◽  
T Watanabe ◽  
S Matsuo ◽  
T Samejima ◽  
J Yamagishi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Coronary Syndrome ◽  
Disease Management ◽  
Oxygen Uptake ◽  
Peak Oxygen Uptake ◽  
Coronary Risk Factors ◽  
Coronary Risk ◽  
Coronary Syndrome

Abstract Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): Grant-in-aid from.jpgu Prefecture Background The newly developed Cardiac Rehabilitation.jpgu Network (CR-GNet) has been implemented to create a regional alliance network and to provide periodic follow-up examinations to enhance the disease management in patients with cardiovascular disease. The effectiveness of a network like this support system has not yet been evaluated in Japan. Purpose We aimed to examine the feasibility of the CR-GNet in disease management, assisting patients in attaining physical fitness and its impact on long-term outcomes after acute coronary syndrome (ACS). Methods We enrolled 47 patients with ACS in the CR-GNet between February 2016 and September 2019; of these, 37, 29, and 21 patients underwent follow-up assessments for exercise capacity (peak oxygen uptake) at 3 months, 6 months, and 1 year after discharge, respectively. Major adverse cardiac events (MACE) were defined as the composite of death from cardiac causes, cardiac arrest, myocardial infarction, and rehospitalization due to unstable or progressive angina. MACE were compared with controls who were not registered in the CR-GNet. Results The coronary risk factors, except blood pressure, improved at 3 and 6 months, and 1 year after discharge. These risk factors in each patient significantly reduced from 2.9 at admission to 1.6, 1.4, and 1.9 at 3 months, 6 months, and 1 year after discharge (p &lt; 0.05), respectively. Peak oxygen uptake was significantly higher at 3 months, 6 months, and 1 year after discharge to 17.5 ± 4.9 ml/kg/min, 17.9 ± 5.1 ml/kg/min, and 17.5 ± 5.5 ml/kg/min, respectively, than that at discharge (14.7 ± 3.6 ml/kg/min) (p &lt; 0.05). During follow-up, there was no significant difference; MACE did not occur in any patients in the CR-GNet but occurred in controls. Conclusions The CR-GNet is a feasible option for long-term management of ACS patients. The prognostic impact of the CR-GNet needs further investigation with a larger sample size and longer follow-up. Table1 At admission 3 months 6 months 1 year Average number 2.9 1.6* 1.4** 1.9*** † Average number of coronary risk factors for all patients (n = 21) p = 0.004, vs. at admission; **p = 0.001, vs. at admission; ***p = 0.011, vs. at admission; †p = 0.035, vs. at 6 months

A 33-yr follow-up of peak oxygen uptake and related variables of former physical education students

1997 ◽  
Vol 82 (6) ◽  
pp. 1844-1852 ◽  
Author(s):  
Per-Olof Åstrand ◽  
Ulf Bergh ◽  
Åsa Kilbom
Keyword(s):  
Heart Rate ◽  
Physical Education ◽  
Oxygen Uptake ◽  
Aerobic Power ◽  
Pulmonary Ventilation ◽  
Peak Oxygen Uptake ◽  
Cycle Ergometer ◽  
Education Students ◽  
Physical Education Students

Åstrand, Per-Olof, Ulf Bergh, and Åsa Kilbom. A 33-yr follow-up of peak oxygen uptake and related variables of former physical education students. J. Appl. Physiol. 82(6): 1844–1852, 1997.—In 1949, 27 female and 26 male physical education students were studied at a mean age of 22 and 25 yr, respectively. They were restudied in 1970 and 1982. Measurements included oxygen uptake, heart rate, and pulmonary ventilation during submaximal and maximal exercise on a cycle ergometer and treadmill. After 21 yr, peak aerobic power was significantly reduced, from 2.90 to 2.18 l/min and from 4.09 to 3.28 l/min for women and men, respectively. After another 12 yr, the 1970 maxima were not reduced further. From 1949 to 1982 there was a decrease in peak heart rate from 196 to 177 beats/min in women and from 190 to 175 beats/min in men ( P < 0.05). Highest pulmonary ventilation did not change significantly. At an oxygen uptake of 1.5 l/min, the heart rate was the same in 1949 as in 1982. In conclusion, the physical fitness level of the subjects was well above average for these ages. From 1970 to 1982 there was no decline in the average peak aerobic power, a finding possibly related to increased habitual physical activity.

scholarly journals The relationship between phosphorus level and peak oxygen uptake in hemodialysis patients awaited for renal transplantation

2019 ◽  
Vol 9 (1) ◽  
pp. 05-05
Author(s):  
Boshra Hasanzamani ◽  
Mohammad Javad Mojahedi ◽  
Saba Khajeh Dargi ◽  
Amir Mohamad Hashem Asnaashari
Keyword(s):  
Renal Transplant ◽  
Oxygen Uptake ◽  
Exercise Capacity ◽  
Peak Oxygen Uptake ◽  
Hemodialysis Patients ◽  
Phosphorus Level ◽  
Vo2 Max ◽  
The Mean ◽  
Transplant Candidates ◽  
The Relationship

Introduction: End-stage renal disease (ESRD) is one of the most common diseases, which affects many aspects of patients’ lives. The measurement of exercise capacity through peak oxygen uptake is an important factor in predicting mortality and survival in patients with ESRD. Objectives: In the current study, we aimed to examine the relationship between phosphorus level and VO2 uptake in renal transplant candidates receiving hemodialysis. Patients and Methods: Thirty renal transplant candidates on hemodialysis were evaluated through spirometry and exercise tests. Then, the results were compared according to the inclusion criteria of age, gender, and phosphorus level. Results: All of cases were male with the mean age of 37.93±10.48 years (range; 20-55 years). Mean VO2 max was 23.46±8.22 mL/kg/min (range; 6.88 to 43.44 mL/kg/min). The mean phosphorus level was 6±2.3 mg/dL (range; 2-10.6 mg/dL) since eight patients had high levels of phosphorus (more than 5.5 mg/dL). In patients with low phosphorus level an abnormal VO2 max was detected (P=0.027). Furthermore, Fisher’s exact test reflected a significant association between higher levels of phosphorus with normal VO2 max (P=0.029). Conclusion: In hemodialysis, decreased blood phosphorus is a predisposing factor for reduced exercise capacity, while hypophosphatemia may lower VO2 max through reducing energy of skeletal muscles. The relationship between phosphorus level and VO2 max may be related to morbidity in hemodialysis patients. Hence, treatment modalities reducing serum levels of phosphorus should be conducted with caution in some patients.

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