VP04.24: The benefit of serum inflammatory markers and simple ultrasound features in the preoperative diagnosis of peri‐ and postmenopausal adnexal masses

AbstractSerum inflammatory markers are used in the prognostication of colorectal cancer (CRC); however, the corresponding role of positron emission tomography (PET)-derived inflammatory markers remains unclear. This study aimed to investigate the prognostic value of 18F-fluorodeoxyglucose (FDG) uptake in the bone marrow and spleen of patients with CRC and evaluate the relationship between FDG uptake estimates in these organs and serum inflammatory markers. In total, 411 patients who underwent preoperative FDG PET/computed tomography (CT) within 1 month of surgery were enrolled. The mean standardized uptake values of the bone marrow and spleen were normalized to the value of the liver, thereby generating bone marrow-to-liver uptake ratio (BLR) and spleen-to-liver uptake ratio (SLR) estimates. The value of BLR and SLR in predicting overall survival (OS) was assessed using the Cox proportional hazards model. The correlation between BLR or SLR and neutrophil-to-lymphocyte ratio (NLR) was evaluated. The predictive accuracy of BLR alone and in combination with SLR was compared using the integrated area under the receiver operating characteristic curves (iAUC). In the univariate analysis, BLR (> 1.06) and SLR (> 0.93) were significant predictors of OS. In the multivariate analysis, BLR was an independent predictor of OS (hazard ratio = 5.279; p < 0.001). Both BLR and SLR were correlated with NLR (p < 0.001). A combination of BLR and SLR was better than BLR alone at CRC prognostication (iAUC, 0.561 vs. 0.542). FDG uptake estimates in the bone marrow and spleen may be useful imaging-derived biomarkers of systemic inflammation, supporting CRC prognostication.

Download Full-text

Reader response: Acute elevation of serum inflammatory markers predicts symptom recovery after concussion

Neurology ◽

10.1212/wnl.0000000000009662 ◽

2020 ◽

Vol 94 (24) ◽

pp. 1111.2-1112

Author(s):

Nitin K. Sethi

Keyword(s):

Reader Response ◽

Inflammatory Markers ◽

Acute Elevation ◽

Symptom Recovery ◽

Serum Inflammatory Markers

Download Full-text

OC25.02: Intercenter variability in ultrasound features of malignant and benign adnexal masses

Ultrasound in Obstetrics and Gynecology ◽

10.1002/uog.6606 ◽

2009 ◽

Vol 34 (S1) ◽

pp. 48-49

Author(s):

L. Ameye ◽

C. Van Holsbeke ◽

A. Testa ◽

L. I. Valentin ◽

R. Fruscio ◽

...

Keyword(s):

Adnexal Masses ◽

Ultrasound Features

Download Full-text

Contribution of Serum Inflammatory Markers to Changes in Bone Mineral Content and Density in Postmenopausal Women: A 1-Year Investigation

Journal of Clinical Densitometry ◽

10.1016/j.jocd.2010.04.003 ◽

2010 ◽

Vol 13 (3) ◽

pp. 277-282 ◽

Cited By ~ 28

Author(s):

E.R. Gertz ◽

N.E. Silverman ◽

K.S. Wise ◽

K.B. Hanson ◽

D.L. Alekel ◽

...

Keyword(s):

Bone Mineral Content ◽

Postmenopausal Women ◽

Bone Mineral ◽

Inflammatory Markers ◽

Mineral Content ◽

Serum Inflammatory Markers

Download Full-text

Diagnostic accuracy of serum inflammatory markers in late fracture-related infection

The Bone & Joint Journal ◽

10.1302/0301-620x.100b12.bjj-2018-0586.r1 ◽

2018 ◽

Vol 100-B (12) ◽

pp. 1542-1550 ◽

Cited By ~ 13

Author(s):

J. van den Kieboom ◽

P. Bosch ◽

J. D. J. Plate ◽

F. F. A. IJpma ◽

R. Kuehl ◽

...

Keyword(s):

Diagnostic Accuracy ◽

Sensitivity And Specificity ◽

Inflammatory Markers ◽

Meta Analysis ◽

Diagnostic Value ◽

Mixed Effects Models ◽

C Reactive Protein ◽

Reactive Protein ◽

Erythrocyte Sedimentation ◽

Serum Inflammatory Markers

Aims To assess the diagnostic value of C-reactive protein (CRP), leucocyte count (LC), and erythrocyte sedimentation rate (ESR) in late fracture-related infection (FRI). Materials and Methods PubMed, Embase, and Cochrane databases were searched focusing on the diagnostic value of CRP, LC, and ESR in late FRI. Sensitivity and specificity combinations were extracted for each marker. Average estimates were obtained using bivariate mixed effects models. Results A total of 8284 articles were identified but only six were suitable for inclusion. Sensitivity of CRP ranged from 60.0% to 100.0% and specificity from 34.3% to 85.7% in all publications considered. Five articles were pooled for meta-analysis, showing a sensitivity and specificity of 77.0% and 67.9%, respectively. For LC, this was 22.9% to 72.6%, and 73.5% to 85.7%, respectively, in five articles. Four articles were pooled for meta-analysis, resulting in a 51.7% sensitivity and 67.1% specificity. For ESR, sensitivity and specificity ranged from 37.1% to 100.0% and 59.0% to 85.0%, respectively, in five articles. Three articles were pooled in meta-analysis, showing a 45.1% sensitivity and 79.3% specificity. Four articles analyzed the value of combined inflammatory markers, reporting an increased diagnostic accuracy. These results could not be pooled due to heterogeneity. Conclusion The serum inflammatory markers CRP, LC, and ESR are insufficiently accurate to diagnose late FRI, but they may be used as a suggestive sign in its diagnosis.

Download Full-text

Serum inflammatory markers as predictors of neurological status in patients with stroke in the course of hypertension: a two-center study

Arterial Hypertension ◽

10.5603/ah.2018.0009 ◽

2018 ◽

Vol 22 (2) ◽

pp. 87-94

Author(s):

Martyna Anna Nowak ◽

Maria Magdalena Nowak ◽

Paula Irmina Walczak ◽

Maciej Wojciech Olszewski ◽

Natalia Niedziela MD, PhD ◽

...

Keyword(s):

Inflammatory Markers ◽

Neurological Status ◽

Serum Inflammatory Markers ◽

Center Study

Download Full-text

Effects of Metformin-Single Therapy on the Level of Inflammatory Markers in Serum of Non-Obese T2DM Patients with NAFLD

Endocrine Metabolic & Immune Disorders - Drug Targets ◽

10.2174/1871530321666210225110140 ◽

2021 ◽

Vol 21 ◽

Author(s):

Bojan Mitrovic ◽

Zoran Gluvic ◽

Djuro Macut ◽

Milan Obradovic ◽

Emina Sudar-Milovanovic ◽

...

Keyword(s):

Fatty Liver ◽

Inflammatory Markers ◽

Liver Steatosis ◽

Diagnostic Procedures ◽

Abdominal Ultrasound ◽

C Reactive Protein ◽

Subsequent Increase ◽

Alcoholic Fatty Liver ◽

Reactive Protein ◽

Serum Inflammatory Markers

Background and Objectives : Non-alcoholic fatty liver disease (NAFLD) is associated with inflammation and subsequent increase in cardiovascular risk. Because of its widespread presence and distribution, invasive diagnostic procedures (i.e., liver biopsy) are reserved for a limited number of subjects. With liver ultrasound, Fatty liver index (FLI) and fibrosis-4 (FIB-4) scores non-invasively assess liver steatosis and fibrosis. We aimed to evaluate the changes in inflammatory markers and FLI/FIB-4 scores in non-obese metformin-treated type 2 diabetes patients (T2DM) with NAFLD. Methods: All subjects underwent abdominal ultrasound aiming for NAFLD stratification (grade 1 to 3 according to its severity). Metabolic parameters (morning glycaemia, HbA1C, lipids, liver function tests) and serum inflammatory markers (C-reactive protein, ferritin, and nitric oxide), and FLI/FIB-4 are calculated. Results: FLI score and ultrasound NAFLD grades correlated (p<0.05). We observed a significant correlation between the levels of ferritin and C-reactive protein (CRP) (p<0.05), and the FLI (p<0.05). Body weight (BW) (p<0.05), waist circumference (WC) (p<0.05), the levels of HbA1c (p<0.05), transferrin (p<0.05), insulin (p<0.05), and FLI score (p<0.05) significantly differed between groups defined by the severity of NAFLD. Conclusion: This pilot study suggests that the serum inflammatory markers at the average normal values point to the sufficiency of metformin-single therapy in inflammation control in non-obese T2DM patients with NAFLD.

Download Full-text

Acute elevation of serum inflammatory markers predicts symptom recovery after concussion

Neurology ◽

10.1212/wnl.0000000000007864 ◽

2019 ◽

Vol 93 (5) ◽

pp. e497-e507 ◽

Cited By ~ 17

Author(s):

Morgan E. Nitta ◽

Jonathan Savitz ◽

Lindsay D. Nelson ◽

T. Kent Teague ◽

James B. Hoelzle ◽

...

Keyword(s):

Inflammatory Markers ◽

Assessment Tool ◽

Characteristic Curve ◽

Serum Levels ◽

Outcome Variable ◽

Duration Of Symptoms ◽

Severity Scores ◽

Symptom Recovery ◽

Factor C ◽

Serum Inflammatory Markers

ObjectiveTo test the hypothesis that acute elevations in serum inflammatory markers predict symptom recovery after sport-related concussion (SRC).MethodsHigh school and collegiate football players (n = 857) were prospectively enrolled. Forty-one athletes with concussion and 43 matched control athletes met inclusion criteria. Serum levels of interleukin (IL)–6, IL-1β, IL-10, tumor necrosis factor, C-reactive protein, interferon-γ, and IL-1 receptor antagonist and Sport Concussion Assessment Tool, 3rd edition (SCAT3) symptom severity scores were collected at a preinjury baseline, 6 and 24–48 hours postinjury, and approximately 8, 15, and 45 days following concussion. The number of days that athletes were symptomatic following SRC (i.e., duration of symptoms) was the primary outcome variable.ResultsIL-6 and IL-1RA were significantly elevated in athletes with concussion at 6 hours relative to preinjury and other postinjury visits, as well as compared to controls (ps ≤ 0.001). IL-6 and IL-1RA significantly discriminated concussed from control athletes at 6 hours postconcussion (IL-6 area under receiver operating characteristic curve 0.79 [95% confidence interval (CI) 0.65–0.92], IL-1RA AUC 0.79 [95% CI 0.67–0.90]). Further, IL-6 levels at 6 hours postconcussion were significantly associated with the duration of symptoms (hazard ratio for symptom recovery = 0.61 [95% CI 0.38–0.96], p = 0.031).ConclusionsResults support the potential utility of IL-6 and IL-1RA as serum biomarkers of SRC and demonstrate the potential of these markers in identifying athletes at risk for prolonged recovery after SRC.Classification of evidenceThis study provides Class III evidence that serum levels of IL-6 and IL-1RA 6 hours postconcussion significantly discriminated concussed from control athletes.

Download Full-text