scholarly journals Prognostic significance of bone marrow and spleen 18F-FDG uptake in patients with colorectal cancer

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jae-Hoon Lee ◽  
Hye Sun Lee ◽  
Soyoung Kim ◽  
Eun Jung Park ◽  
Seung Hyuk Baik ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Bone Marrow ◽  
Inflammatory Markers ◽  
Univariate Analysis ◽  
Prognostic Significance ◽  
Uptake Ratio ◽  
Liver Uptake ◽  
Fdg Uptake ◽  
Standardized Uptake Values ◽  
Serum Inflammatory Markers

AbstractSerum inflammatory markers are used in the prognostication of colorectal cancer (CRC); however, the corresponding role of positron emission tomography (PET)-derived inflammatory markers remains unclear. This study aimed to investigate the prognostic value of 18F-fluorodeoxyglucose (FDG) uptake in the bone marrow and spleen of patients with CRC and evaluate the relationship between FDG uptake estimates in these organs and serum inflammatory markers. In total, 411 patients who underwent preoperative FDG PET/computed tomography (CT) within 1 month of surgery were enrolled. The mean standardized uptake values of the bone marrow and spleen were normalized to the value of the liver, thereby generating bone marrow-to-liver uptake ratio (BLR) and spleen-to-liver uptake ratio (SLR) estimates. The value of BLR and SLR in predicting overall survival (OS) was assessed using the Cox proportional hazards model. The correlation between BLR or SLR and neutrophil-to-lymphocyte ratio (NLR) was evaluated. The predictive accuracy of BLR alone and in combination with SLR was compared using the integrated area under the receiver operating characteristic curves (iAUC). In the univariate analysis, BLR (> 1.06) and SLR (> 0.93) were significant predictors of OS. In the multivariate analysis, BLR was an independent predictor of OS (hazard ratio = 5.279; p < 0.001). Both BLR and SLR were correlated with NLR (p < 0.001). A combination of BLR and SLR was better than BLR alone at CRC prognostication (iAUC, 0.561 vs. 0.542). FDG uptake estimates in the bone marrow and spleen may be useful imaging-derived biomarkers of systemic inflammation, supporting CRC prognostication.

scholarly journals Prognostic significance of bone marrow FDG uptake in patients with gynecological cancer

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kotaro Shimura ◽  
Seiji Mabuchi ◽  
Naoko Komura ◽  
Eriko Yokoi ◽  
Katsumi Kozasa ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Bone Marrow ◽  
Poor Prognosis ◽  
Gynecological Cancer ◽  
Prognostic Significance ◽  
Standardized Uptake Value ◽  
Suppressor Cells ◽  
Underlying Mechanism ◽  
Fdg Uptake

AbstractWe investigated the prognostic significance and the underlying mechanism of increased bone marrow (BM) 2-(18F) fluoro-2-deoxy-D-glucose as a tracer (FDG)-uptake in patients with gynecological cancer. A list of patients diagnosed with cervical, endometrial, and ovarian cancer from January 2008 to December 2014 were identified. Then, through chart reviews, 559 patients who underwent staging by FDG-positron emission tomography (PET)/computed tomography (CT) and subsequent surgical resection were identified, and their clinical data were reviewed retrospectively. BM FDG-uptake was evaluated using maximum standardized uptake value (SUVmax) and BM-to-aorta uptake ratio (BAR). As a result, we have found that increased BAR was observed in 20 (8.7%), 21 (13.0%), 21 (12.6%) of cervical, endometrial, and ovarian cancer, respectively, and was associated with significantly shorter survival. Increased BAR was also closely associated with increased granulopoiesis. In vitro and in vivo experiments revealed that tumor-derived granulocyte colony-stimulating factor (G-CSF) was involved in the underlying causative mechanism of increased BM FDG-uptake, and that immune suppression mediated by G-CSF-induced myeloid-derived suppressor cells (MDSCs) is responsible for the poor prognosis of this type of cancer. In conclusion, increased BM FDG-uptake, as represented by increased BAR, is an indicator of poor prognosis in patients with gynecological cancer.

scholarly journals Prognostic Significance of Serum Inflammatory Markers in Gastric Cancer

2017 ◽  
Vol 152 (5) ◽  
pp. S1268
Author(s):  
Arfon G. Powell ◽  
Tarig Abdelrahman ◽  
Chris Brown ◽  
Neil Patel ◽  
Tim Havard ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Inflammatory Markers ◽  
Prognostic Significance ◽  
Serum Inflammatory Markers

scholarly journals Prognostic significance of serum inflammatory markers in esophageal cancer

Esophagus ◽  
2020 ◽  
Author(s):  
Arfon G. M. T. Powell ◽  
◽  
Catherine Eley ◽  
Carven Chin ◽  
Alexandra H Coxon ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Inflammatory Markers ◽  
Prognostic Significance ◽  
Serum Inflammatory Markers

scholarly journals Intratumoral Cytotoxic T-Lymphocyte Density and PD-L1 Expression Are Prognostic Biomarkers for Patients with Colorectal Cancer

Medicina ◽  
2019 ◽  
Vol 55 (11) ◽  
pp. 723 ◽  
Author(s):  
Calik ◽  
Calik ◽  
Turken ◽  
Ozercan ◽  
Dagli ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Multivariate Analysis ◽  
Tumor Microenvironment ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Univariate Analysis ◽  
Prognostic Significance ◽  
Prognostic Biomarkers ◽  
Cell Surface Glycoprotein ◽  
Significant Difference

Background and objectives: Cytotoxic T-lymphocyte (CTL)-mediated inflammatory response to tumors plays a crucial role in preventing the progression of some cancers. Programmed cell death ligand 1 (PD-L1), a cell-surface glycoprotein, has been reported to repress T-cell-mediated immune responses against tumors. However, the clinical significance of PD-L1 in colorectal cancer (CRC) remains unclear. Our aim was to elucidate the prognostic significance of PD-L1 expression and CD8+ CTL density in CRC. Materials and methods: CD8 and PD-L1 immunostaining was conducted on 157 pathologic specimens from patients with CRC. The CD8+ CTL density and PD-L1 expression within the tumor microenvironment were assessed by immunohistochemistry. Results: Tumor invasion (pT) was significantly correlated with intratumoral (p = 0.011) and peritumoral (p = 0.016) CD8+ CTLs density in the tumor microenvironment. In addition, there was a significant difference in the intensity of CD8+ CTLs between patients with and without distant metastases (intratumoral p = 0.007; peritumoral p = 0.037, T-test). Lymph node metastasis (pN) and TNM stage were significantly correlated with PD-L1 expression in CRC cells (p = 0.015, p = 0.029, respectively). Multivariate analysis revealed a statistically significant relationship between the intratumoral CD8+ CTL density and disease-free survival (DFS) (hazard ratio [HR] 2.06; 95% confidence interval [CI]: 1.01–4.23; p = 0.043). The DFS was considerably shorter in patients with a high expression of PD-L1 in cancer cells than those with a low expression (univariate HR 2.55; 95% CI 1.50–4.34; p = 0.001; multivariate HR 0.48; 95% CI 0.28–0.82; p = 0.007). Conversely, patients with high PD-L1 expression in tumor-infiltrating lymphocytes had a longer DFS in both univariate analysis (HR 0.25; 95% CI: 0.14–0.44; p < 0.001) and multivariate analysis (HR 3.42; 95% CI: 1.95–6.01; p < 0.001). Conclusion: The CD8+ CTL density and PD-L1 expression are prognostic biomarkers for the survival of patients with CRC.

scholarly journals Serum Inflammatory Markers and Risk of Colorectal Cancer in Patients With Inflammatory Bowel Diseases

2014 ◽  
Vol 12 (8) ◽  
pp. 1342-1348.e1 ◽  
Author(s):  
Ashwin N. Ananthakrishnan ◽  
Su–Chun Cheng ◽  
Tianxi Cai ◽  
Andrew Cagan ◽  
Vivian S. Gainer ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Inflammatory Bowel Diseases ◽  
Inflammatory Markers ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Serum Inflammatory Markers

Adverse Prognostic Effect of Methylation in Colorectal Cancer Is Reversed by Microsatellite Instability

2003 ◽  
Vol 21 (20) ◽  
pp. 3729-3736 ◽  
Author(s):  
Robyn Lynne Ward ◽  
Kay Cheong ◽  
Su-Lyn Ku ◽  
Alan Meagher ◽  
Terence O’Connor ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Methylation ◽  
Microsatellite Instability ◽  
Univariate Analysis ◽  
Prognostic Significance ◽  
Curative Surgery ◽  
Fresh Tissue ◽  
Vascular Space ◽  
Response To Chemotherapy ◽  
Vascular Space Invasion

Purpose: DNA methylation is an important biologic event in colorectal cancer and in some cases is associated with the development of microsatellite instability (MSI). In this study, we sought to determine the prognostic significance of DNA methylation, both in univariate analysis and in concert with other clinicopathologic factors known to influence outcome. Patients and Methods: Fresh tissue (625 cancers) was obtained from 605 individuals (age range, 29 to 99 years) undergoing curative surgery for colorectal cancer at one institution during a period of 8 years. Clinicopathologic details were recorded for all tumors, including stage, grade, type, vascular space invasion, and clinical follow-up to 5 years. Microsatellite status was assessed using standard markers. Methylation of p16 and hMLH1 promoters was determined by methylation-specific polymerase chain reaction (PCR), whereas methylation at methylated-in-tumor loci (MINT)1, MINT2, MINT12, and MINT31 loci were assessed by bisulfite-PCR. Results: Patients with microsatellite unstable tumors (12%) had better disease-specific survival than those with microsatellite stable (MSS) tumors (univariate analysis: hazard ratio [HR], 0.53; 95% CI, 0.27 to 1.0). Overall survival of individuals with MSS tumors was influenced by three independently significant factors: tumor stage (HR, 7.3; 95% CI, 5.1 to 10.4), heavy tumor methylation (HR, 2.1; 95% CI, 1.1 to 4.0), and vascular space invasion (HR, 1.9; 95% CI, 1.3 to 2.9). In MSS tumors, methylation at any single site was not independently predictive of survival. Neither methylation nor microsatellite status predicted a favorable response to chemotherapy. Conclusion: DNA methylation is associated with a worse outcome in colorectal cancer, but this adverse prognostic influence is lost in those methylated tumors showing MSI. The mechanisms of these events warrant additional investigation.

Prognostic significance of micrometastatic tumour cells in bone marrow of colorectal cancer patients

The Lancet ◽  
1992 ◽  
Vol 340 (8821) ◽  
pp. 685-689 ◽  
Author(s):  
F. Lindemann ◽  
J. Witte ◽  
G. Schlimok ◽  
P. Dirschedl ◽  
G. Riethmuller
Keyword(s):  
Colorectal Cancer ◽  
Bone Marrow ◽  
Cancer Patients ◽  
Prognostic Significance ◽  
Tumour Cells ◽  
Colorectal Cancer Patients

scholarly journals Serum inflammatory markers and colorectal cancer risk and survival

2017 ◽  
Vol 116 (10) ◽  
pp. 1358-1365 ◽  
Author(s):  
Sundeep Ghuman ◽  
Mieke Van Hemelrijck ◽  
Hans Garmo ◽  
Lars Holmberg ◽  
Håkan Malmström ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Inflammatory Markers ◽  
Colorectal Cancer Risk ◽  
Serum Inflammatory Markers

Analysis of FDG PET Diffuse Bone Marrow Uptake in Staging of Hodgkin’s Disease: A Reflect of Disease Infiltration or Just Inflammation?.

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 1456-1456
Author(s):  
Pierre Y Salaun ◽  
Thomas Gastine ◽  
Loic Campion ◽  
Pierre Cambefort ◽  
Caroline Bodet-Milin ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Fdg Pet ◽  
Univariate Analysis ◽  
Bone Marrow Involvement ◽  
Tumor Burden ◽  
Rank Test ◽  
Liver Uptake ◽  
Bulky Disease ◽  
Inflammatory Parameters ◽  
Bone Marrow Uptake

Abstract FDG-PET has been successfully evaluated in the management of Hodgkin’s lymphoma (HL) and the most recent international guidelines recommended FDG-PET for initial staging and final therapeutic assessment. However, FDG PET diffuse bone marrow uptake (BMU) is frequently observed and remains difficult to analyse. The aim of this study was to evaluate the correlation between bone marrow involvement and BMU in HD. Methods: 106 HD patients (median age was 31 years range from 9 to 81; male gender in 23 cases) who underwent FDG PET/CT were retrospectively analysis. BMU level was graduated according to liver uptake. In addition, as semi-quantitative reference SUVmax was assessed upon sacral promontory. These data were compared with patient characteristics including age, Ann Arbor staging, bulky disease (Tumor burden &gt; 10 cm), presence of B symptoms, bone foci on PET (n=106), bone marrow biopsy (n=75), leukocyte count (n=74), LDH (n=87) and inflammatory parameters measured in the serum (C-Reactive Protein (CRP) (n=83) and fibrinogen (n=60)). Univariate and multivariate analysis were performed. A Fisher’s exact test and a Kruskal-Wallis equality of population rank test were used to analyse qualitative and quantitative parameters, respectively. Results: No statistical link was found between BMU and stage, bulky disease, bone marrow involvement (BMI), bone foci on PET or LDH. In contrast, univariate analysis showed correlation between BMU and age (p =0.0001), B symptoms (p =0.028 for clinical), CRP (p=0.0001), fibrinogen (p=0.0111) and leukocyte (p=0.0024). Multivariate parameters analysis found independent correlation between BMU and CRP level (p&lt;0.0001). Sacrum SUV was correlated with inflammatory parameters as BMU and with disease extension parameters like stage (p=0.0001), BMI on biopsy (p=0.0127) and bone foci on PET (p=0.0498). No BMI was found in patients presented with SUVmax below 3.5. Conclusion: This study demonstrates that the intensity of FDG-PET bone marrow uptake in HD is not correlated to BMI but related to inflammatory parameters probably reflecting the cellular activation within the BM. Semi-quantitative analysis of SUV could be useful to improve bone uptake interpretation because no infiltration is found under a SUV level.

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