The most effective medication for aesthetic correction of skin scars is ultraphonophoresis of enzyme preparations. Under our supervision there were 20 patients aged 17.2 ± 2.4 years with a symptomatic complex who received a course of ultraphonophoresis of hyaluronidase cream (15 procedures performed every other day). Efficacy was assessed taking into account clinical high-grade indices: Vancouver scale, POSAS, Dermatological Life Quality Index. Efficacy according to the Vancouver scale was 100% for pain, itching decreased by 75% after 2 months and completely stopped after 6 months, color of the scar improved by 50%, stiffness decreased by 67%, thickness of scar deformation decreased by 50%. Ultraphonophoresis of hyaluronidase cream is a highly effective method of correction of the scars of the symptom complex postacne, which also determines the improvement in the quality of life of this category of patients according to the dynamics of the dermatological quality of life index. This method can be recommended for use in clinical practice.