The influence of illness-related variables, personal resources and context-related factors on real-life functioning of people with schizophrenia

IntroductionWellness self-management is an adaptation and expansion of the illness management and recovery, an internationally recognized best practice. WSM is a recovery-oriented, curriculum-based practice designed to help adults with severe mental health problems make decisions and take action to manage symptoms and improve their quality of life.ObjectivesIn the present study, the Italian translation of the WSM was implemented and validated. Moreover, the impact of its application in a day hospital setting on cognitive functions, psychopathology, personal resources and real-life functioning with respect to treatment as usual (TAU) was investigated.AimsThe study was aimed at assessing the effectiveness of a semi-structured version of WSM in a day hospital setting in patients with severe mental illness.MethodsFourteen patients with a diagnosis of severe mental illness were recruited and randomly assigned to either WSM or TAU. WSM participants attended four 2-hour sessions per week for 1 month, including lessons selected on the basis of the goals of participants. Both groups received weekly planned treatment in the day-hospital setting and continued their pharmacotherapy.ResultsThe two groups of patients were comparable for age, education, cognitive functioning and psychopathological severity. WSM produced a significantly greater improvement in neurocognition, psychopathology, personal resources and real-life functioning with respect to TAU.ConclusionsOur results offer promising preliminary evidence that the use of WSM provides an effective complement to current mental health treatment.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Download Full-text

Sensory gating, neurocognition, social cognition and real-life functioning: a 2-year follow-up of early psychosis

Psychological Medicine ◽

10.1017/s0033291721004463 ◽

2021 ◽

pp. 1-13

Author(s):

Shen Li ◽

Shi Yu Chan ◽

Amy Higgins ◽

Mei-Hua Hall

Keyword(s):

Psychotic Disorders ◽

Mixed Model ◽

Real Life ◽

Sensory Gating ◽

Early Psychosis ◽

Global Functioning ◽

Chi Square ◽

Life Functioning ◽

Inference Test

Abstract Background Diminished sensory gating (SG) is a robust finding in psychotic disorders, but studies of early psychosis (EP) are rare. It is unknown whether SG deficit leads to poor neurocognitive, social, and/or real-world functioning. This study aimed to explore the longitudinal relationships between SG and these variables. Methods Seventy-nine EP patients and 88 healthy controls (HCs) were recruited at baseline. Thirty-three and 20 EP patients completed 12-month and 24-month follow-up, respectively. SG was measured using the auditory dual-click (S1 & S2) paradigm and quantified as P50 ratio (S2/S1) and difference (S1-S2). Cognition, real-life functioning, and symptoms were assessed using the MATRICS Consensus Cognitive Battery, Global Functioning: Social (GFS) and Role (GFR), Multnomah Community Ability Scale (MCAS), Awareness of Social Inference Test (TASIT), and the Positive and Negative Syndrome Scale (PANSS). Analysis of variance (ANOVA), chi-square, mixed model, correlation and regression analyses were used for group comparisons and relationships among variables controlling for potential confounding variables. Results In EP patients, P50 ratio (p < 0.05) and difference (p < 0.001) at 24-month showed significant differences compared with that at baseline. At baseline, P50 indices (ratio, S1-S2 difference, S1) were independently associated with GFR in HCs (all p < 0.05); in EP patients, S2 amplitude was independently associated with GFS (p = 0.037). At 12-month and 24-month, P50 indices (ratio, S1, S2) was independently associated with MCAS (all p < 0.05). S1-S2 difference was a trending predictor of future function (GFS or MCAS). Conclusions SG showed progressive reduction in EP patients. P50 indices were related to real-life functioning.

Download Full-text

T196. A Longitudinal Study of Relationships Between Resting State Functional Connectivity and Real-Life Functioning in Early Psychosis

Biological Psychiatry ◽

10.1016/j.biopsych.2019.03.519 ◽

2019 ◽

Vol 85 (10) ◽

pp. S206

Author(s):

Shi Yu Chan ◽

Melissa Hwang ◽

Amy Higgins ◽

Kathryn Nielsen ◽

Dost Ongur ◽

...

Keyword(s):

Longitudinal Study ◽

Functional Connectivity ◽

Resting State ◽

Real Life ◽

Early Psychosis ◽

Resting State Functional Connectivity ◽

Life Functioning

Download Full-text

The social cognition individualized activities lab: Implementation of a new remediation intervention for social cognition

European Psychiatry ◽

10.1016/j.eurpsy.2016.01.2102 ◽

2016 ◽

Vol 33 (S1) ◽

pp. S567-S567

Author(s):

D. Palumbo ◽

A. Mucci ◽

G. Piegari ◽

M. Chieffi ◽

A. Mazza ◽

...

Keyword(s):

Social Skills ◽

Social Cognition ◽

Real Life ◽

The Social ◽

Study Results ◽

Life Functioning ◽

Individualized Training ◽

Group Sessions ◽

Individualized Activities ◽

The Impact

IntroductionPeople with schizophrenia exhibit deficits in neurocognitive and social cognitive (SC) processes which limit their social reintegration. SC was found to mediate in part the impact of neurocognitive dysfunctions on real-life functioning.ObjectiveThe purpose of this study was to implement a new intervention for patients with schizophrenia, the Social Cognition Individualized Activities Lab (So.C.I.A.L.) which trains both social cognition and neurocognitive functions.AimsTo determine the efficacy of the So.C.I.A.L in improving SC by a comparison with a validated cognitive remediation (CR) intervention: the Social Skills And Neurocognitive Individualized Training (SSANIT).MethodsNine stabilized patients accepted to participate in this pilot study. Five were randomized to So.C.I.A.L. and 4 to SSANIT. The two programs were matched for the overall treatment duration (20 weeks), as well as frequency and duration of the sessions. Both interventions included individual sessions of neurocognitive individualized training; So.C.I.A.L included group sessions on Emotion Recognition and Theory of Mind, while SSANIT group sessions of Social Skills Individualized Training.ResultsNo group difference was found for changes in neurocognition, while a significant group effect was observed for changes in SC, due to improvement only in the So.C.I.A.L. group.ConclusionsThe study results showed a specific effect of the So.C.I.A.L. on SC, beyond the effect on neurocognition. Further studies are needed to assess the impact of So.C.I.A.L. on real-life functioning in a larger group of subjects.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Download Full-text

Relationships between neurocognition, social cognition and functional outcome in schizophrenia

European Psychiatry ◽

10.1016/j.eurpsy.2016.01.970 ◽

2016 ◽

Vol 33 (S1) ◽

pp. S67-S67 ◽

Cited By ~ 1

Author(s):

A. Mucci ◽

S. Galderisi ◽

A. Rossi ◽

P. Rocca ◽

A. Bertolino ◽

...

Keyword(s):

Social Cognition ◽

Functional Outcome ◽

Functional Capacity ◽

Indirect Effects ◽

Structural Equation ◽

Real Life ◽

Equation Model ◽

Direct And Indirect Effects ◽

Neurocognitive Deficits ◽

Life Functioning

IntroductionThe inter-relationships of neurocognition, social cognition, residual psychopathology and real-life functioning are poorly understood. A large multicenter study was carried out by the Italian Network for Research on Psychoses to model relationships between neurocognitive deficits, psychopathology and real-life functioning, taking into account the role of functional capacity and social cognition.MethodsA structural equation model was used to investigate direct and indirect effects of neurocognition and psychopathology on real-life functioning. Social cognition and functional capacity were modeled as mediators.ResultsIn 921 patients with schizophrenia, neurocognition had both direct and indirect effects, through functional capacity and social cognition, on real-life functioning. Neurocognition predicted to a large extent social cognition on which depression and disorganization had a modest effect. Social cognition showed a significant direct impact on real-life functioning.ConclusionOur results support a strong link between neurocognition and functional outcome, independent of psychopathology. Social cognition accounted for unique incremental variance in real-life functioning.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Download Full-text

Uveitis related factors in patients with spondyloarthritis; TReasure real life results

American Journal of Ophthalmology ◽

10.1016/j.ajo.2021.03.026 ◽

2021 ◽

Author(s):

Nazife Şule Yaşar Bilge ◽

Umut Kalyoncu ◽

Pamir Atagündüz ◽

Ediz Dalkılıç ◽

Yavuz Pehlivan ◽

...

Keyword(s):

Real Life ◽

Related Factors

Download Full-text

Factors Influencing Complication Rates at Colonic Polypectomy: A Prospective Study from a Tertiary-Referral Center

Romanian Journal Of Internal Medicine ◽

10.1515/rjim-2015-0007 ◽

2015 ◽

Vol 53 (1) ◽

pp. 52-55

Author(s):

Th. Voiosu ◽

B. Busuioc ◽

A. Voiosu ◽

Andreea Bengus ◽

M. Rimbas ◽

...

Keyword(s):

Multivariate Analysis ◽

Standard Form ◽

Real Life ◽

Colon Resection ◽

Complication Rates ◽

Polyp Size ◽

Related Factors ◽

Tertiary Referral Center ◽

Low Volume ◽

The Impact

AbstractBackground and aims. Colon polypectomy decreases the incidence of colorectal cancer and related mortality. Several factors such as the size, location and type of polyp as well as endoscopist experience have been shown to correlate with the risk of ensuing procedure-related complications. This study aims to evaluate the impact of polyp and endoscopist-related factors on the rate of postpolypectomy complication in a real-life setting.Methods. During the study period all polypectomies performed in our unit were reported on a standard form that included data on polyp type (flat, sessile, pedunculated), size, location in the colon, resection method, endoscopist volume and procedure-related complications arising up to 30 days. The main outcome was the complication rate of polypectomies. The factors that associated with a higher risk of complications were assessed on univariate and multivariate analysis.Results. 244 polyp resections from 95 patients were included in the analysis. 199 polyps were resected by low-volume endoscopists (44.7%) and 135 polypectomies were performed by highvolume endoscopists (55.3%). On multivariate analysis only polyp size correlated with the risk of procedure-related complications.Conclusion. Polyp size is the most important risk factor for procedure-related complications. Both high and low-volume endoscopists have a low overall rate of serious complications.

Download Full-text

Product importance and complexity as determinants of adaptation processes in business relationships

Journal of Business and Industrial Marketing ◽

10.1108/jbim-07-2012-0116 ◽

2014 ◽

Vol 29 (1) ◽

pp. 75-87 ◽

Cited By ~ 3

Author(s):

Cristina Sales Baptista

Keyword(s):

Adaptive Behavior ◽

Real Life ◽

Mining Industry ◽

Business Relationships ◽

Related Factors ◽

Capital Equipment ◽

Content Type ◽

Study Approach ◽

Adaptation Processes

Purpose – The aim of this paper is to characterize adaptation processes in business relationships. The nature of adaptive behavior is described by outlining activities and events in these relationships. The role of perceived product importance and complexity in the character of the adaptations processes is sought. Design/methodology/approach – A case study approach is adopted and two long-term relationships between buyers and sellers of capital equipment in the mining industry are investigated. Perspectives from both sides of the dyad (buyer and seller) were attained through in-depth interviews. Findings – Findings show that supplier-based adaptations occur more frequently than customer-based adaptations. The market antecedents of concentration and resource dependency are identified as drivers of adaptive behavior. Furthermore, product importance and complexity are key drivers to adaptation processes and the development of long-term relationships. Supplier's brand name and the choice of a direct channel strategy are identified as indicators of long-term commitment to the market. Moreover, two-task related factors were extremely relevant as selection criteria for capital equipment: the functional suitability and the degree of standardization/customization of the equipment. Research limitations/implications – The findings are specific to the market environment and recommendations are given for the realm of the mining industry. Multi-case studies in multi-contexts should be conducted to enable generalization and potential theory-building. Practical implications – A number of important managerial implications for buyers and sellers of capital equipment in the mining industry are given. Originality/value – This paper contributes to knowledge by providing rich descriptions of adaptation processes. This real life evidence enables the identification of major drivers of adaptive behavior and, consequently, the development of long-term successful relationships.

Download Full-text