Partial Leptin Receptor Gene Deletion in Transgenic Mice Prevents Expression of the Membrane-Bound Isoforms Except for Ob-Rc

2000 ◽  
Vol 269 (2) ◽  
pp. 496-501 ◽  
Author(s):  
Ursula Reichart ◽  
Roland Kappler ◽  
Harry Scherthan ◽  
Eckhard Wolf ◽  
Mathias Müller ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Gene Deletion ◽  
Leptin Receptor ◽  
Receptor Gene ◽  
Membrane Bound

Contrasting Obesity Phenotypes Uncovered by Partial Leptin Receptor Gene Deletion in Transgenic Mice

2000 ◽  
Vol 269 (2) ◽  
pp. 502-507 ◽  
Author(s):  
Ursula Reichart ◽  
Ingrid Renner-Müller ◽  
Andreas Höflich ◽  
Oliver J. Müller ◽  
Wolfgang M. Franz ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Gene Deletion ◽  
Leptin Receptor ◽  
Receptor Gene

Association between leptin receptor gene polymorphism and quality of both meat and back fat in large white pigs of ukrainian breeding

2016 ◽  
Vol 3 (2) ◽  
pp. 42-48
Author(s):  
V. Balatsky ◽  
I. Bankovska ◽  
A. Saienko
Keyword(s):  
Gene Polymorphism ◽  
Leptin Receptor ◽  
Receptor Gene ◽  
Intramuscular Fat ◽  
Large White ◽  
Pig Breeds ◽  
Lepr Gene ◽  
Large White Breed ◽  
White Breed

Leptin receptor is one of the components of the system of regulating energy homeostasis of the organism. Leptin receptor gene (LEPR) polymorphism is associated with pig carcass index of the content of intramus- cular fat in its valuable parts, which is particularly important when assessing the quality of their carcasses for processing. Intramuscular fat is associated with meat fl avor characteristics and partly determines its tenderness, juiciness, and other parameters. Aim. To analyze LEPR gene (SNP NM001024587.1, p. 1987 C > T) polymor- phism in populations of various pig breeds and to establish its relationship with the quality of both meat and fat of pigs of Large White breed of Ukrainian breeding. Methods. Genetic-population analysis of nine pig breeds, associative analysis on the search connection of LEPR gene polymorphism with quality of both meat and fat of pigs of Large White breed of Ukrainian breeding. LEPR locus genotyping was performed by High Resolution Melting (HRM). Results. All the studied breeds are characterized by polymorphism of the leptin receptor gene (SNP NM001024587.1, p. 1987 C > T), signifi cant breed specifi city in the distribution of frequencies of alleles was established. Statistically confi rmed effect (p < 0.05) of genotypes LEPR on the content of intramuscular fat, total dry matter and moisture in the meat, as well as the moisture content in the back fat of pigs of Ukrainian Large White breed was revealed. Higher content of intramuscular fat was found in the animals with genotype TT, while a smaller amount of intramuscular fat and more moisture in fat was revealed in heterozygotes. Conclusions. Genetic marker LEPR SNP NM001024587.1, p. 1987 C > T can be used in the marker-assisted selection to predict and improve the performance quality of the meat of pigs of Large White breed of the Ukrainian breeding. These results suggest that porcine leptin receptor gene controls the quality of fat comp- lex – inside muscles and in the dorsal part of the carcass.

Impact of leptin and leptin-receptor gene polymorphisms on serum lipids in Japanese obese children

2010 ◽  
Vol 99 (8) ◽  
pp. 1213-1217 ◽  
Author(s):  
T Okada ◽  
T Ohzeki ◽  
Y Nakagawa ◽  
S Sugihara ◽  
O Arisaka ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Serum Lipids ◽  
Leptin Receptor ◽  
Receptor Gene ◽  
Obese Children ◽  
Receptor Gene Polymorphisms

scholarly journals The Trend in Distribution of Q223R Mutation of Leptin Receptor Gene in Amoebic Liver Abscess Patients from North India: A Prospective Study

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Anil Kumar Verma ◽  
Vineet Ahuja ◽  
Jaishree Paul
Keyword(s):  
Liver Abscess ◽  
Leptin Receptor ◽  
Receptor Gene ◽  
Rflp Analysis ◽  
North India ◽  
Amoebic Liver Abscess ◽  
Fisher Exact Test ◽  
Exact Test ◽  
Pcr Rflp ◽  
A Prospective Study

Host genetic susceptibility is an important risk factor in infectious diseases. We explored the distribution of Q223R mutation in leptin receptor gene of amoebic liver abscess (ALA) patients of North India. A total of 55 ALA samples along with 102 controls were subjected to PCR-RFLP analysis. The frequency of allele “G” (coding for arginine) was in general high in Indian population irrespective of the disease. Our results of Fisher exact test shows that heterozygous mutant (QQ versus QR,P=0.049) and homozygous mutant (QQ versus RR,P=0.004) were significantly associated with amoebic liver abscess when compared with homozygous wild (QQ).

Leptin and Leptin Receptor Gene Polymorphisms in Obstructive Sleep Apnea Syndrome

CHEST Journal ◽  
2008 ◽  
Vol 133 (1) ◽  
pp. 79-85 ◽  
Author(s):  
Masayuki Hanaoka ◽  
Xiujun Yu ◽  
Kazuhisa Urushihata ◽  
Masao Ota ◽  
Keisaku Fujimoto ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Obstructive Sleep Apnea Syndrome ◽  
Gene Polymorphisms ◽  
Leptin Receptor ◽  
Receptor Gene ◽  
Sleep Apnea Syndrome ◽  
Obstructive Sleep ◽  
Apnea Syndrome ◽  
Receptor Gene Polymorphisms

Melanocortin-4 Receptor Gene Variation Is Associated with Eating Behavior in Chilean Adults

2015 ◽  
Vol 68 (1) ◽  
pp. 35-41 ◽  
Author(s):  
Javier A. Vega ◽  
Gloria Salazar ◽  
María Isabel Hodgson ◽  
Luis Rodrigo Cataldo ◽  
Macarena Valladares ◽  
...  
Keyword(s):  
Eating Behavior ◽  
Emotional Eating ◽  
Leptin Receptor ◽  
Receptor Gene ◽  
Pathogenic Mutation ◽  
Gene Variation ◽  
Mc4r Gene ◽  
Melanocortin 4 Receptor ◽  
Melanocortin 4 Receptor Gene ◽  
Mc4r Rs17782313

Background/Aims: To evaluate the association between allelic variants of melanocortin receptors -3 and -4 (MC3R and MC4R, respectively) and leptin receptor (LEPR) genes with body mass index (BMI) and eating behavior. Methods: We selected 344 Chilean adults (57.8% women; age 39.1 ± 6.6 years) with a wide variation in BMI (30.3 ± 6.3 kg/m2). The Three-Factor Eating Questionnaire-R18 that measures uncontrolled eating (UE), emotional eating (EE) and cognitive restraint scores was adapted, validated and assessed for association with BMI. Genotypes were determined by polymerase chain reaction followed by restriction fragment length polymorphism techniques and Taqman assays. Results: Higher EE scores were found in obese vs. non-obese in both men (p = 0.01) and women (p < 0.001). UE scores were significantly associated with BMI only in women (p = 0.002). No significant differences in eating behavior scores or BMI were found by LEPR (rs1137101, rs8179183 and rs1137100 polymorphisms) or MC3R (rs3746619 and rs3827103). Carriers of the C allele for MC4R rs17782313 showed significantly higher scores of UE compared to non-carriers (2.3 ± 0.8 vs. 2.0 ± 0.7; p = 0.02). Additionally, we also report a monogenic case of obesity carrying the pathogenic mutation 449C>T (Thr150Ile) in MC4R gene with no apparent alterations in eating behavior scores. Conclusions: UE scores were higher in C-allele carriers of MC4R-rs17782313 compared to non-carriers.

scholarly journals Susceptibility of gastric cancer according to leptin and leptin receptor gene polymorphisms in Korea

2012 ◽  
Vol 83 (1) ◽  
pp. 7 ◽  
Author(s):  
Eun-Young Kim ◽  
Hyung-Min Chin ◽  
Seung-Man Park ◽  
Hae-Myung Jeon ◽  
Woo-Chul Chung ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gene Polymorphisms ◽  
Leptin Receptor ◽  
Receptor Gene ◽  
Receptor Gene Polymorphisms

scholarly journals Genetic Variation in the Leptin Receptor Gene, Leptin, and Weight Gain in Young Dutch Adults

2003 ◽  
Vol 11 (3) ◽  
pp. 377-386 ◽  
Author(s):  
Caroline T.M. van Rossum ◽  
Barbara Hoebee ◽  
Marleen A. van Baak ◽  
Monica Mars ◽  
Wim H.M. Saris ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Weight Gain ◽  
Leptin Receptor ◽  
Receptor Gene
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