Effects of Calorie Restriction on Transforming Growth Factor β1 and Proinflammatory Cytokines in Murine Sjogren's Syndrome

1995 ◽  
Vol 76 (3) ◽  
pp. 291-296 ◽  
Author(s):  
Bysani Chandrasekar ◽  
H.Stan McGuff ◽  
Thomas B. Aufdermorte ◽  
Dean A. Troyer ◽  
Norman Talal ◽  
...  
Keyword(s):  
Growth Factor ◽  
Sjögren’S Syndrome ◽  
Calorie Restriction ◽  
Proinflammatory Cytokines ◽  
Transforming Growth Factor ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Transforming Growth Factor Β1 ◽  
Sjogren's Syndrome ◽  
Sjögren‘S Syndrome

scholarly journals Salivary transforming growth factor alpha in patients with Sjögren's syndrome and reflux laryngitis

2014 ◽  
Vol 80 (6) ◽  
pp. 462-469 ◽  
Author(s):  
Marco Antonio dos Anjos Corvo ◽  
Claudia Alessandra Eckley ◽  
Luis Vicente Rizzo ◽  
Luiz Roberto Sardinha ◽  
Tomas Navarro Rodriguez ◽  
...  
Keyword(s):  
Growth Factor ◽  
Sjögren’S Syndrome ◽  
Transforming Growth Factor ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Transforming Growth Factor Alpha ◽  
Reflux Laryngitis ◽  
Factor Alpha ◽  
Sjögren‘S Syndrome

Analysis of Transforming Growth Factor β and Other Cytokines in Autoimmune Exocrinopathy (Sjögren's Syndrome)

1995 ◽  
Vol 15 (9) ◽  
pp. 759-767 ◽  
Author(s):  
NORIYOSHI OGAWA ◽  
HOWARD DANG ◽  
KONSTANTINOS LAZARIDIS ◽  
H. STAN McGUFF ◽  
THOMAS B. AUFDEMORTE ◽  
...  
Keyword(s):  
Growth Factor ◽  
Sjögren’S Syndrome ◽  
Transforming Growth Factor ◽  
Sjögren's Syndrome ◽  
Transforming Growth Factor Β ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Autoimmune Exocrinopathy ◽  
Sjögren‘S Syndrome

scholarly journals SMADS-Mediate Molecular Mechanisms in Sjögren’s Syndrome

2021 ◽  
Vol 22 (6) ◽  
pp. 3203
Author(s):  
Margherita Sisto ◽  
Domenico Ribatti ◽  
Sabrina Lisi
Keyword(s):  
Sjögren’S Syndrome ◽  
Molecular Mechanisms ◽  
Target Genes ◽  
Transforming Growth Factor ◽  
Sjögren's Syndrome ◽  
Biological Effects ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Mesenchymal Transition ◽  
Sjögren‘S Syndrome

There is considerable interest in delineating the molecular mechanisms of action of transforming growth factor-β (TGF-β), considered as central player in a plethora of human conditions, including cancer, fibrosis and autoimmune disease. TGF-β elicits its biological effects through membrane bound serine/threonine kinase receptors which transmit their signals via downstream signalling molecules, SMADs, which regulate the transcription of target genes in collaboration with various co-activators and co-repressors. Until now, therapeutic strategy for primary Sjögren’s syndrome (pSS) has been focused on inflammation, but, recently, the involvement of TGF-β/SMADs signalling has been demonstrated in pSS salivary glands (SGs) as mediator of the epithelial-mesenchymal transition (EMT) activation. Although EMT seems to cause pSS SG fibrosis, TGF-β family members have ambiguous effects on the function of pSS SGs. Based on these premises, this review highlights recent advances in unravelling the molecular basis for the multi-faceted functions of TGF-β in pSS that are dictated by orchestrations of SMADs, and describe TGF-β/SMADs value as both disease markers and/or therapeutic target for pSS.

scholarly journals Modulation of Matrix Metalloproteinases in Sjogren's Syndrome by Proinflammatory Cytokines

1970 ◽  
Vol 24 (2) ◽  
pp. 15-20
Author(s):  
Enamul Kabir ◽  
Nick Di Girolamo ◽  
Denis Wakefield
Keyword(s):  
Matrix Metalloproteinases ◽  
Key Words ◽  
Sjögren’S Syndrome ◽  
Proinflammatory Cytokines ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Key Words Sjögren's Syndrome ◽  
Sjögren‘S Syndrome

Key words: Sjogren's syndrome; Matrixmetalloproteinases (MMPS);Proinflammatory cytokinesDOI: 10.3329/bjpath.v24i2.4113Bangladesh J Pathol 24(2): 15-20

Correlation between salivary epidermal growth factor levels and refractory intraoral manifestations in patients with Sjögren's syndrome

2013 ◽  
Vol 24 (4) ◽  
pp. 626-632 ◽  
Author(s):  
Naoto Azuma ◽  
Yoshinori Katada ◽  
Sachie Kitano ◽  
Masahiro Sekiguchi ◽  
Masayasu Kitano ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Epidermal Growth ◽  
Sjögren‘S Syndrome

scholarly journals Increased production of B cell growth factor (BCGF) in Sjögren's syndrome

1996 ◽  
Vol 9 (4) ◽  
pp. 545-550 ◽  
Author(s):  
Yoshie Goto ◽  
Mitsuyasu Itoh ◽  
Noriyoshi Ogawa ◽  
Yoshinori Goto ◽  
Hiroyuki Ohashi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cell Growth ◽  
B Cell ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
B Cell Growth Factor ◽  
Sjögren‘S Syndrome
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