Immune Complexes Bound to the Primate Erythrocyte Complement Receptor (CR1) via Anti-CR1 Mabs Are Cleared Simultaneously with Loss of CR1 in a Concerted Reaction in a Rhesus Monkey Model

1997 ◽  
Vol 82 (1) ◽  
pp. 49-59 ◽  
Author(s):  
Ronald P. Taylor ◽  
Polly J. Ferguson ◽  
Edward N. Martin ◽  
James Cooke ◽  
Kirsten L. Greene ◽  
...  

Author(s):  
D. Marsh

As a result of vasectomy, spermatozoa are confined to the epididymis and vas deferens, where they degenerate, releasing antigens that enter the circulation or are engulfed by macrophages. Multiple antigens of the sperm can elicit production of autoantibodies; circulating anti-sperm antibodies are found in a large percentage of vasectomized men, indicating the immunogenicity of the sperm. The increased prevalence of macrophages in the liomen of the rhesus monkey testicular efferent ducts after vasectomy led to further study of this region. Frozen sections were used for evaluation of immunopathological status by fluorescence microscopy with fluorescein-conjugated antibody. Subsequent granular deposits of immune complexes were revealed by positive immunofluorescence staining for complement. The immune complex deposition in the basement membrane surrounding the efferent ducts implies that this region is involved in antigen leakage (Fig. 1).



1980 ◽  
Vol 1 (2) ◽  
pp. 149-160 ◽  
Author(s):  
Richard G. Olsen ◽  
Toby A. Griner ◽  
George D. Prettyman
Keyword(s):  


2006 ◽  
Vol 43 (10) ◽  
pp. 1595-1603 ◽  
Author(s):  
Barbara Schraml ◽  
M. Angeles Baker ◽  
Brian D. Reilly


2017 ◽  
Vol 134 ◽  
pp. 273-282 ◽  
Author(s):  
Yajie Chi ◽  
Bolin Wu ◽  
Jianwei Guan ◽  
Kuntai Xiao ◽  
Ziming Lu ◽  
...  


Author(s):  
J. M. Ziriax ◽  
C. M. Furse ◽  
J. A. D’Andrea ◽  
J.-H. Gao ◽  
P. A. Mason ◽  
...  
Keyword(s):  


2020 ◽  
pp. 1-7
Author(s):  
Erin E. Perrone ◽  
Laura A. Galganski ◽  
Alice F. Tarantal ◽  
Katie J. Olstad ◽  
Marjorie C. Treadwell ◽  
...  

<b><i>Introduction:</i></b> Open fetal surgery requires a hemostatic hysterotomy that minimizes membrane separation. For over 30 years, the standard of care for hysterotomy in the gravid uterus has been the AutoSuture Premium Poly CS*-57 stapler. <b><i>Objective:</i></b> In this study, we sought to test the feasibility of hysterotomy in a rhesus monkey model with the Harmonic ACE®+7 Shears. <b><i>Methods:</i></b> A gravid rhesus monkey underwent midgestation hysterotomy at approximately 90 days of gestation (2nd trimester; term = 165 ± 10 days) using the Harmonic ACE®+7 Shears. A two-layer uterine closure was completed and the dam was monitored by ultrasound intermittently throughout the pregnancy. At 58 days after hysterotomy (near term), a final surgery was performed to evaluate the uterus and hysterotomy site. <b><i>Results:</i></b> A 3.5-cm hysterotomy was completed in 2 min 7 s. The opening was hemostatic and the membranes were sealed. Immediately after closure and throughout the pregnancy, ultrasound revealed intact membranes without separation and normal amniotic fluid levels. At term, the scar was well healed without signs of thinning or dehiscence. <b><i>Conclusions:</i></b> The Harmonic ACE®+7 Shears produced a hemostatic midgestation hysterotomy with membrane sealing in the rhesus monkey model. Importantly, healing was acceptable.



1980 ◽  
Vol 152 (4) ◽  
pp. 905-919 ◽  
Author(s):  
F M Griffin

The effects of ingestion of soluble immune complexes upon macrophage phagocytic function was studied. Ingestion of immune complexes severely impaired the macrophage's ability to ingest IgG-coated particles but did not alter its ability to interact with particles by means other than its Fc receptors. Treatment of macrophages that had ingested immune complexes with supernates containing the previously described lymphokine that augments macrophage complement receptor function failed to enhance the cells' interaction with either IgG-coated erythrocytes or zymosan particles but markedly enhanced their ability to phagocytize via their complement receptors. The possible significance of these findings in immunologically mediated inflammation is discussed.



2003 ◽  
Vol 25 (3) ◽  
pp. 263-267 ◽  
Author(s):  
Hongjun Li ◽  
Zhanlong He ◽  
Ting Su ◽  
Yanbing Ma ◽  
Shuaiyao Lu ◽  
...  


2014 ◽  
Vol 123 (01) ◽  
pp. e1-e1 ◽  
Author(s):  
Shuai-yao. Lu ◽  
Su-dong. Qi ◽  
Yuan. Zhao ◽  
Yan-yan. Li ◽  
Feng-mei. Yang ◽  
...  


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