Low-Risk Endometrial Carcinoma: Assessment of a Treatment Policy Based on Tumor Ploidy and Identification of Additional Prognostic Indicators

1999 ◽  
Vol 73 (2) ◽  
pp. 191-195 ◽  
Author(s):  
Peter Lim ◽  
Christina F. Aquino-Parsons ◽  
Frances Wong ◽  
Bev Dupuis ◽  
Don Phillips ◽  
...  
Keyword(s):  
Endometrial Carcinoma ◽  
Low Risk ◽  
Prognostic Indicators ◽  
Treatment Policy ◽  
Tumor Ploidy

Prognosis-associated methylation subtypes in endometrial carcinoma patients and the role of magnetic nanoparticles in gene extraction

2021 ◽  
Vol 11 (8) ◽  
pp. 1288-1298
Author(s):  
Liang Wang ◽  
Fengxia Xue
Keyword(s):  
Endometrial Cancer ◽  
Magnetic Nanoparticles ◽  
Endometrial Carcinoma ◽  
High Throughput Sequencing ◽  
Risk Groups ◽  
Vital Role ◽  
Low Risk ◽  
The Cancer Genome Atlas ◽  
Consensus Clustering ◽  
Tumor Subtypes

Endometrial cancer is one of the most common gynecological malignancies, and DNA methylation plays a vital role in its occurrence and development. In this study, we collected the relevant data on endometrial cancer from the Cancer Genome Atlas database and UCSC website. By screening and processing the data, we obtained 410 samples and 16,381 methylation sites. Endometrial carcinoma can be divided into seven molecular subtypes using consensus clustering method. Based on the analysis of the differences among subtypes, the methylation degree of different sites was obtained, and the prognosis model of methylation sites was established. Based on the median value of the train group, the train and test groups were divided into high and low-risk groups. The survival between the high and low-risk groups was different. It also showed that this model can predict the survival of patients, with better accuracy. In conclusion, the tumor subtypes based on methylation sites can provide a better guidance for treatment, relapse, and prognosis of endometrial cancer. In this study, magnetic nanoparticles can be used to extract genomic DNA and total RNA due to their paramagnetism and biocompatibility, then transcriptome high-throughput sequencing was performed. It may serve as potential cancer immune biomarker targets for developing future oncological treatments.

Recurrence of low risk (LR), early stage endometrial carcinoma (EC), a clinicopathologic analysis

2015 ◽  
Vol 139 (3) ◽  
pp. 599
Author(s):  
Tinera Buckley ◽  
Mary Belniak ◽  
Amy Brown ◽  
Srinivas Mandavilli ◽  
X. Clare Zhou
Keyword(s):  
Endometrial Carcinoma ◽  
Early Stage ◽  
Low Risk

An Epidemiological Assessment of Endometrial Carcinoma Including Demographics and Histopathological Correlation, from a Tertiary Care Teaching Hospital in South India

2021 ◽  
Vol 8 (30) ◽  
pp. 2751-2756
Author(s):  
Jeenu Babu ◽  
Reeba George Pulinilkunnathil ◽  
Bindu R. Kumar
Keyword(s):  
Risk Factors ◽  
Endometrial Carcinoma ◽  
Teaching Hospital ◽  
South India ◽  
Tertiary Care ◽  
Endometrial Biopsy ◽  
Prognostic Indicators ◽  
Histopathological Correlation ◽  
History Of ◽  
The Mean

BACKGROUND Endometrial cancer (EC) is also the second most common gynaecologic malignancy in developing countries, with an incidence of 5.9 per 100,000 women. Due to the multiple modifiable factors, a better understanding of the prognostic indicators can lead to early detection and treatment. The purpose of this study was to evaluate the frequency and the distribution of various risk factors, epidemiological factors, and histological patterns of patients diagnosed with endometrial carcinoma in a tertiary teaching hospital in south India and compare them with similar studies. The compiled findings of 60 consecutive cases that presented to our tertiary care teaching hospital in Kerala, south India, over oneand-a-half-year period were studied. METHODS This study was essentially an ex post facto retrospective study done on 60 patients for one and half years. Retrospective data collection and compilation were done with previously prepared structured questionnaires in patients with histologically proven endometrial carcinoma. All cases were subjected to hysterectomy with post-surgical histopathology correlation. A study of the risk factors, general epidemiological characteristics, endometrial biopsy findings, and post-surgical histopathology was done. RESULTS The mean age at presentation was 59.83 years. The mean age of menarche was 13.72 years, and menopause was 49.42 years. The majority of patients were married, multiparous, and presented with bleeding per vaginum (77 %). 61.7 % of the patients had a history of hypertension, 31.7 % had a history of hypothyroidism, and 43.3 % had a history of diabetes mellitus in the study population. The most common histopathological type by endometrial biopsy and histopathological correlation was endometrioid adenocarcinoma (88.3 %). CONCLUSIONS Postmenopausal age group, with early menarche and late menopause, high body mass index (BMI), thickened endometrium on ultrasound, and atrophic uterus were some of the features associated with endometrial carcinoma. The most common histological subtype was found to be endometrioid carcinoma KEYWORDS Endometrial Carcinoma, Risk Factors, Prognostic Indicators

L1CAM: amending the “low-risk” category in endometrial carcinoma

2016 ◽  
Vol 143 (2) ◽  
pp. 255-262 ◽  
Author(s):  
Felix Kommoss ◽  
Friedrich Kommoss ◽  
Friederike Grevenkamp ◽  
Anne-Kathrin Bunz ◽  
Florin-Andrei Taran ◽  
...  
Keyword(s):  
Endometrial Carcinoma ◽  
Low Risk ◽  
Risk Category

Low risk stage I endometrial carcinoma: Prognostic factors and outcomes

2011 ◽  
Vol 48 (2) ◽  
pp. 204 ◽  
Author(s):  
A Yoney ◽  
Y Bati ◽  
C Yildirim ◽  
M Unsal
Keyword(s):  
Prognostic Factors ◽  
Endometrial Carcinoma ◽  
Low Risk ◽  
Stage I

Prognostic indicators of laparotomy findings in clinical stage I-II supradiaphragmatic Hodgkin's disease.

1989 ◽  
Vol 7 (1) ◽  
pp. 81-91 ◽  
Author(s):  
M H Leibenhaut ◽  
R T Hoppe ◽  
B Efron ◽  
J Halpern ◽  
T Nelsen ◽  
...  
Keyword(s):  
Hodgkin's Disease ◽  
Hodgkin’S Disease ◽  
Clinical Stage ◽  
Low Risk ◽  
Prognostic Indicators ◽  
Treatment Programs ◽  
Staging Laparotomy ◽  
Increased Risk ◽  
Splenic Irradiation ◽  
Systemic Symptoms

Between July 1968 and July 1986, 915 patients with clinical stage (CS) I and II Hodgkin's disease limited to sites above the diaphragm underwent laparotomy and splenectomy at Stanford University. Fifteen percent were CS I, of whom 76% had cervical/supraclavicular disease, 13% axillary disease, and 9% mediastinal presentations. CS I patients were more likely to be male, were significantly older, and were significantly less likely to have nodular sclerosis (NS) histology than CS II patients. Twenty percent of CS I patients and 30% of CS II patients were pathologically upstaged. No CS I patients were upstaged to pathological stage (PS) IV. Univariate and multivariate analyses of presenting clinical characteristics were performed to predict staging laparotomy findings. CS I women, CS I patients with mediastinal-only disease, and CS I men with either lymphocyte predominance or interfollicular histologies were at low risk for having disease below the diaphragm (5%) or requiring chemotherapy (0%). CS II women who were less than 27 years old and had only two or three sites of disease were also at low risk for upstaging (9%) or requiring chemotherapy (2%). Mixed cellularity histology and male gender were associated with increased risk for subdiaphragmatic disease and require laparotomy; the presence of systemic symptoms was not correlated with laparotomy findings. These results confirm the importance of performing staging laparotomy for the majority of patients who present with supradiaphragmatic Hodgkin's disease if treatment programs are based on the presence and extent of subdiaphragmatic disease. Selected subgroups are at low risk for subdiaphragmatic disease and might be spared laparotomy if they are treated with mantle, paraaortic, and splenic irradiation.

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