Differential Regulation of Glucose and Glycogen Metabolism in Vascular Smooth Muscle by Exogenous Substrates

1997 ◽  
Vol 29 (4) ◽  
pp. 1207-1216 ◽  
Author(s):  
Christopher D. Hardin ◽  
Tina M. Roberts
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Glycogen Metabolism ◽  
Differential Regulation ◽  
Exogenous Substrates

Differential Regulation ofl-Arginine Transport and Nitric Oxide Production by Vascular Smooth Muscle and Endothelium

1996 ◽  
Vol 78 (6) ◽  
pp. 1075-1082 ◽  
Author(s):  
William Durante ◽  
Lan Liao ◽  
Irfan Iftikhar ◽  
William E. O’Brien ◽  
Andrew I. Schafer
Keyword(s):  
Nitric Oxide ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Differential Regulation ◽  
Nitric Oxide Production ◽  
Arginine Transport ◽  
Oxide Production

Differential effects of fatty acids on glycolysis and glycogen metabolism in vascular smooth muscle

1991 ◽  
Vol 1093 (2-3) ◽  
pp. 125-134 ◽  
Author(s):  
John T. Barron ◽  
Steven J. Kopp ◽  
June P. Tow ◽  
Joseph E. Parrillo
Keyword(s):  
Fatty Acids ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Glycogen Metabolism ◽  
Differential Effects

Differential Regulation of Endothelin-1 Action by Insulin and Vanadate in Vascular Smooth Muscle

1998 ◽  
Vol 31 ◽  
pp. S196-S198 ◽  
Author(s):  
Rob L. Hopfner ◽  
Raghuram V. Hasnadka ◽  
J. Robert McNeill ◽  
Thomas W. Wilson ◽  
Venkat Gopalakrishnan
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Differential Regulation ◽  
Endothelin 1

Glycogen metabolism during tension generation and maintenance in vascular smooth muscle

1989 ◽  
Vol 257 (4) ◽  
pp. C736-C742 ◽  
Author(s):  
R. M. Lynch ◽  
C. P. Kuettner ◽  
R. J. Paul
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Glycogen Phosphorylase ◽  
Glycogen Metabolism ◽  
Metabolic Intermediates ◽  
Active Contraction ◽  
Glycogen Utilization ◽  
Tension Generation ◽  
Muscle Contractile ◽  
Porcine Carotid Artery

To study the regulation of glycogen utilization in vascular smooth muscle, we measured the content of glycogen and glucose 6-phosphate and the activity of the glycogen phosphorylase and glycogen debrancher enzymes in porcine carotid artery. During active contraction, the rates of glycogen phosphorylase and glycogenolysis were as high as expected. Despite this, glycogen content did not decrease to less than approximately 50% of control levels even after sustained contractions. The activity of glycogen debrancher enzyme was found to be limiting glycogen utilization at this point. Although glycogenolysis is closely coordinated with increases in oxidative metabolism concomitant with active contraction, the maximal level of tension obtained after stimulation was not substantially reduced under conditions where glycogen debrancher enzyme was limiting glycogen utilization. On the other hand, the rate of tension generation was increased in these tissues. Thus glycogen utilization is not necessary for maximal force generation per se, but may influence other muscle contractile properties. Finally, during steady-state tension maintenance, glycogen utilization is likely to be regulated by the intracellular concentrations of metabolic intermediates (glucose, glucose 6-phosphate), as it is in skeletal muscle.

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