Cytokine Receptors, Soluble

1998 ◽  
pp. 712-719 ◽  
Author(s):  
David Wallach
Keyword(s):  
Cytokine Receptors

The paracaspase MALT1 in psoriasis

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Stephan Hailfinger ◽  
Klaus Schulze-Osthoff
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Transcription Factors ◽  
Skin Disease ◽  
Cell Types ◽  
Cytokine Receptors ◽  
Molecular Scaffold ◽  
Therapeutic Implications ◽  
Stimulation Of

Abstract Psoriasis is a frequent autoimmune-related skin disease, which involves various cell types such as T cells, keratinocytes and dendritic cells. Genetic variations, such as mutations of CARD14, can promote the development of the disease. CARD14 mutations as well as the stimulation of immune and cytokine receptors activate the paracaspase MALT1, a potent activator of the transcription factors NF-κB and AP-1. The disease-promoting role of MALT1 for psoriasis is mediated by both its protease activity as well as its molecular scaffold function. Here, we review the importance of MALT1-mediated signaling and its therapeutic implications in psoriasis.

scholarly journals Serially measured cytokines and cytokine receptors in relation to clinical outcome in patients with stable heart failure

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
E Bouwens ◽  
A Schuurman ◽  
K.M Akkerhuis ◽  
S.J Baart ◽  
K Caliskan ◽  
...  
Keyword(s):  
Heart Failure ◽  
Clinical Outcome ◽  
Primary Endpoint ◽  
Nyha Class ◽  
Cytokine Receptors ◽  
Funding Source ◽  
Compensatory Mechanism ◽  
Blood Samples ◽  
Two Samples

Abstract Background Activation of the inflammatory response in heart failure (HF) may initially serve as a compensatory mechanism. However, on the longer term, this physiological phenomenon can become disadvantageous. Temporal patterns of inflammatory proteins other than CRP have not yet been investigated in patients with stable HF. Purpose We aimed to evaluate the association of 17 serially measured cytokines and cytokine receptors with clinical outcome in patients with stable heart failure. Methods In 263 patients, 1984 serial, tri-monthly blood samples were collected during a median follow-up of 2.2 (IQR: 1.4–2.5) years. The primary endpoint (PE) composed of cardiovascular mortality, HF-hospitalization, heart transplantation, and LVAD. We selected baseline blood samples in all patients, as well as the two samples closest to the primary endpoint, and the last sample available in event-free patients. Thus, in 567 samples we measured 17 cytokines and cytokine receptors using the Olink Proteomics Cardiovascular III multiplex assay. Associations between biomarkers and PE were investigated by joint modelling. Results Median age was 68 (IQR: 59–76) years, with 72% men, 74% NYHA class I-II and a median ejection fraction of 30% (23–38%). 70 patients reached a PE. After adjustment for clinical characteristics (age, sex, diabetes, atrial fibrillation, NYHA class at baseline, diuretics and systolic blood pressure), 7 biomarkers were associated with the PE (Figure). Interleukin-1 receptor type 1 (IL1RT1) showed the strongest association: HR 2.65 [95% CI: 1.78–4.21]) per standard deviation change in level (NPX) at any point in time during follow-up, followed by Tumor necrosis factor receptor 1 (TNF-R1): 2.25 [1.66–3.08], and C-X-C motif chemokine 16 (CXCL16): 2.18 [1.59–3.04]. After adjustment for baseline N-terminal pro–B-type natriuretic peptide, high-sensitive troponin T and C-reactive protein however, only IL1RT1 and TNF-R1 remained significantly associated with the PE. Conclusion Repeatedly measured levels of several cytokines and cytokine receptors are independently associated with clinical outcome in stable HF patients. These results suggest that repeated measurements of these biomarkers, in addition to established cardiac biomarkers, may contribute to personalized risk assessment and herewith better identify high-risk patients. Figure 1. Associations between levels of cytokines and cytokine receptors and the primary endpoint. Funding Acknowledgement Type of funding source: Other. Main funding source(s): This work was supported by the Jaap Schouten Foundation and the Noordwest Academie.

Expression of extracellular matrix components and cytokine receptors in human fibrocytes during rheumatoid arthritis

2021 ◽  
pp. 1-12
Author(s):  
Dorra Elhaj Mahmoud ◽  
Wajih Kaabachi ◽  
Nadia Sassi ◽  
Amel Mokhtar ◽  
Lobna Ben Ammar ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Extracellular Matrix ◽  
Cytokine Receptors ◽  
Extracellular Matrix Components ◽  
Matrix Components

Role in growth regulation of cytokines and cytokine receptors in acute lymphoblastic leukaemia expressing myeloid markers

1993 ◽  
Vol 84 (3) ◽  
pp. 408-415 ◽  
Author(s):  
Yoshihiro Komada ◽  
Yan-Wen Zhou ◽  
Shao-Li Zhang ◽  
Eiichi Azuma ◽  
Minoru Sakurai
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Growth Regulation ◽  
Cytokine Receptors

Protein expression profiling of cytokines and cytokine receptors on purified chronic lymphocytic leukemia cells from patients with favourable prognostic indicators

2008 ◽  
Vol 49 (4) ◽  
pp. 751-756 ◽  
Author(s):  
Zhifeng Yu ◽  
Baohua Sun ◽  
Hagop M. Kantarjian ◽  
Michael J. Keating ◽  
Hesham M. Amin ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Protein Expression ◽  
Expression Profiling ◽  
Lymphocytic Leukemia ◽  
Cytokine Receptors ◽  
Leukemia Cells ◽  
Prognostic Indicators

Tyrosine kinase activation through the extracellular domains of cytokine receptors

Nature ◽  
1993 ◽  
Vol 362 (6421) ◽  
pp. 646-648 ◽  
Author(s):  
Tomoki Chiba ◽  
Yuka Nagata ◽  
Mitsuru Machide ◽  
Atsushi Kishi ◽  
Hiroshi Amanuma ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Cytokine Receptors ◽  
Kinase Activation ◽  
Extracellular Domains

The Interferon-γ Receptor: A Comparison with Other Cytokine Receptors

1990 ◽  
Vol 10 (6) ◽  
pp. 551-558 ◽  
Author(s):  
MICHEL AGUET
Keyword(s):  
Interferon Γ ◽  
Cytokine Receptors

scholarly journals Expression of cytokines and cytokine receptors in human Schwann cells

Neuroreport ◽  
2008 ◽  
Vol 19 (1) ◽  
pp. 31-35 ◽  
Author(s):  
Akihiko Ozaki ◽  
Atsushi Nagai ◽  
Yong B. Lee ◽  
Na H. Myong ◽  
Seung U. Kim
Keyword(s):  
Schwann Cells ◽  
Cytokine Receptors

HL-3 Class II cytokine receptors and their ligands: Diversities and similarities

Cytokine ◽  
2010 ◽  
Vol 52 (1-2) ◽  
pp. 1
Author(s):  
Sergei V. Kotenko
Keyword(s):  
Class Ii ◽  
Cytokine Receptors

Cytokine receptors and signal transduction

1992 ◽  
Vol 6 (15) ◽  
pp. 3387-3396 ◽  
Author(s):  
Tetsuya Taga ◽  
Tadamitsu Kishimoto
Keyword(s):  
Signal Transduction ◽  
Cytokine Receptors
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