The William Beaumont Hospital Technique of Interstitial Brachytherapy

2006 ◽  
pp. 91-103 ◽  
Author(s):  
Peter Y. Chen ◽  
Greg Edmundson
Keyword(s):  
Beaumont Hospital ◽  
Interstitial Brachytherapy

Stereotactic Radiosurgery: The Experience of the Neurotology and Skull Base Unit at Beaumont Hospital

2012 ◽  
Vol 73 (S 02) ◽  
Author(s):  
M. Khan ◽  
M. Sadadcharam ◽  
R. Wormald ◽  
M. Javadpour ◽  
D. Rawluk ◽  
...  
Keyword(s):  
Skull Base ◽  
Stereotactic Radiosurgery ◽  
Beaumont Hospital ◽  
Base Unit

scholarly journals 458. Molecular SARS-CoV-2 Testing During the COVID-19 Outbreak: Experiences of a Hospital in Southeast Michigan, USA

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S296-S297
Author(s):  
Trini A Mathew ◽  
Jonathan Hopkins ◽  
Diane Kamerer ◽  
Shagufta N Ali ◽  
Daniel Ortiz ◽  
...  
Keyword(s):  
Clinical Features ◽  
Diagnostic Testing ◽  
Beaumont Hospital ◽  
High Capacity ◽  
Turnaround Time ◽  
Molecular Diagnostic ◽  
The Novel ◽  
Repeat Testing ◽  
Asymptomatic Patients ◽  
Novel Coronavirus

Abstract Background The novel Coronavirus SARS CoV-2 (COVID-19) outbreak was complicated by the lack of diagnostic testing kits. In early March 2020, leadership at Beaumont Hospital, Royal Oak Michigan (Beaumont) identified the need to develop high capacity testing modalities with appropriate sensitivity and specificity and rapid turnaround time. We describe the molecular diagnostic testing experience since initial rollout on March 16, 2020 at Beaumont, and results of repeat testing during the peak of the COVID-19 pandemic in MI. Methods Beaumont is an 1100 bed hospital in Southeast MI. In March, testing was initially performed with the EUA Luminex NxTAG CoV Extended Panel until March 28, 2020 when testing was converted to the EUA Cepheid Xpert Xpress SARS-CoV-2 for quicker turnaround times. Each assay was validated with a combination of patient samples and contrived specimens. Results During the initial week of testing there was > 20 % specimen positivity. As the prevalence grew the positivity rate reached 68% by the end of March (Figure 1). Many state and hospital initiatives were implemented during the outbreak, including social distancing and screening of asymptomatic patients to increase case-finding and prevent transmission. We also adopted a process for clinical review of symptomatic patients who initially tested negative for SARS-CoV-2 by a group of infectious disease physicians (Figure 2). This process was expanded to include other trained clinicians who were redeployed from other departments in the hospital. Repeat testing was performed to allow consideration of discontinuation of isolation precautions. During the surge of community cases from March 16 to April 30, 2020, we identified patients with negative PCR tests who subsequently had repeat testing based on clinical evaluation, with 7.1% (39/551) returning positive for SARS- CoV2. Of the patients who expired due to COVID-19 during this period, 4.3% (9/206) initially tested negative before ultimately testing positive. Figure 1 BH RO testing Epicurve Figure 2: Screening tool for repeat COVID19 testing and precautions Conclusion Many state and hospital initiatives helped us flatten the curve for COVID-19. Our hospital testing experience indicate that repeat testing may be warranted for those patients with clinical features suggestive of COVID-19. We will further analyze these cases and clinical features that prompted repeat testing. Disclosures All Authors: No reported disclosures

PO-0255 CT-guided high-dose interstitial brachytherapy vs. SBRT in hepatocellular carcinoma

2021 ◽  
Vol 158 ◽  
pp. S210
Author(s):  
F. Walter ◽  
A.S. Duque ◽  
H. Weingandt ◽  
J. Well ◽  
R. Shpani ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Interstitial Brachytherapy ◽  
High Dose ◽  
Ct Guided

scholarly journals Role of interstitial brachytherpy using template (mupit) in locally advanced carcinoma cervix

2016 ◽  
Author(s):  
Ashish Bhange ◽  
Abhishek Gulia ◽  
Anirudh Punnakal ◽  
Anil Kumar Anand ◽  
Anil Kumar Bansal ◽  
...  
Keyword(s):  
Local Control ◽  
Residual Disease ◽  
Locally Advanced ◽  
Concurrent Chemotherapy ◽  
Interstitial Brachytherapy ◽  
Carcinoma Cervix ◽  
Advanced Carcinoma ◽  
Needle Position ◽  
Grade 3

Introduction: Locally advanced carcinoma cervix includes stages IIB, IIIA, IIIB and IVA. Interstitial brachytherapy has the potential to deliver adequate dose to lateral parametrium and to vagina. Hence, it is preferable in cases with distorted anatomy, extensive (lower) vaginal wall involvement, bulky residual disease post EBRT and parametrium involvement upto lateral pelvic wall. Aim and Objective: To determine clinical outcome and complications (acute and chronic) in locally advanced carcinoma cervix, treated with interstitial brachytherapy using template (MUPIT - Martinez universal perineal interstitial template). Materials and Methods: This study is a retrospective analysis of 37 cases of locally advanced carcinoma cervix (stage IIB-2, IIIB-30, IVA-5), treated with EBRT (dose-median 45Gy/25#) ± concurrent chemotherapy (CCT) - Inj. Cisplatin/Inj Carboplatin, followed by interstitial brachytherapy using MUPIT from December 2009 to June 2015. Initial treatment with EBRT ± CCT was followed by intertstitial brachytherapy. Under spinal anaesthesia and epidural analgesia, MUPIT application was done. Straight and divergent needles (median 26, range 19-29) were inserted to cover parametrium adequately. Needle position was verified with planning CT scan and Brachytherapy planning was done. Dose was normalized to 5 mm box surface from outermost needle with optimization of dose to OAR (Bladder, Rectum and Sigmoid colon). Prescription dose –25Gy in 5#. Treatment was delivered by Microselectron HDR using Ir192 source. Treatment fractions were delivered twice daily with min 6 Hrs. gap in-between fractions. Results: The median duration of follow-up was 25 months. Local control was achieved in 28 patients with residual disease in 7 patients and local recurrence in 2 patients. 10 patients had acute lower GI toxicity {Grade1 (n=6), Grade 2 (n=4)}, 2 patients had acute Grade 1 bladder toxicity. 1 patient had grade 3 and 1 patient had grade 4 chronic bladder toxicity. Chronic rectal toxicity was seen in 10 patients {Grade 2 (n=4), Grade 3 (n=4), Grade 4 (n=2)}. Conclusion: Local control was achieved in 28/37 patients (75.6%) and overall survival rate of 81.1% at median follow up of 25 months in patients with locally advanced carcinoma cervix and unfavorable prognostic factors.

scholarly journals Use of transrectal ultrasound for high dose rate interstitial brachytherapy for patients of carcinoma of uterine cervix

2010 ◽  
Vol 21 (1) ◽  
pp. 12 ◽  
Author(s):  
Daya Nand Sharma ◽  
Goura Kisor Rath ◽  
Sanjay Thulkar ◽  
Sunesh Kumar ◽  
Vellaiyan Subramani ◽  
...  
Keyword(s):  
Dose Rate ◽  
Uterine Cervix ◽  
Transrectal Ultrasound ◽  
High Dose Rate ◽  
Interstitial Brachytherapy ◽  
High Dose

Long-term outcome for very high-risk prostate cancer treated primarily with a triple modality approach to include permanent interstitial brachytherapy

Brachytherapy ◽  
2012 ◽  
Vol 11 (4) ◽  
pp. 250-255 ◽  
Author(s):  
Nathan Bittner ◽  
Gregory S. Merrick ◽  
Wayne M. Butler ◽  
Robert W. Galbreath ◽  
Jonathan Lief ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Interstitial Brachytherapy ◽  
Term Outcome ◽  
Long Term Outcome ◽  
High Risk Prostate Cancer ◽  
Risk Prostate Cancer ◽  
Modality Approach ◽  
Very High

N28 HDR INTERSTITIAL BRACHYTHERAPY AS THE ORGAN PRESERVATION TREATMENT OF PENILE NEOPLASM

2010 ◽  
Vol 9 (6) ◽  
pp. 541-542
Author(s):  
M. Giglok ◽  
B. Bialas ◽  
M. Fijalkowski ◽  
B. Smolska-Ciszewska ◽  
S. Kellas-Slęczka ◽  
...  
Keyword(s):  
Organ Preservation ◽  
Interstitial Brachytherapy ◽  
Penile Neoplasm

scholarly journals Changing Trends in the Management of Esthesioneuroblastoma: Irish and International Perspectives

2017 ◽  
Vol 79 (03) ◽  
pp. 262-268 ◽  
Author(s):  
Thavakumar Subramaniam ◽  
Mary Leader ◽  
Rory McConn-Walsh ◽  
James O'Neill ◽  
Peter Lacy ◽  
...  
Keyword(s):  
Nasal Congestion ◽  
Beaumont Hospital ◽  
Open Approach ◽  
Disease Specific Survival ◽  
Management Options ◽  
Postoperative Radiation Therapy ◽  
Tertiary Referral Center ◽  
Changing Trends ◽  
International Perspectives ◽  
Disease Specific

Objectives Evaluation of the changing trends in esthesioneuroblastoma in an Irish context and review of management options nationally to clarify the best current therapeutic approach by comparing with international research on this uncommon malignancy. Design Retrospective review. Setting Tertiary referral center. Participants All patients presenting with esthesioneuroblastoma in Beaumont hospital or on the National Cancer Registry of Ireland between 1994 and 2013. Main Outcome Measures Recurrence-free and overall survival. Results During the study period, 32 cases of esthesioneuroblastoma were diagnosed (0.4 per million per year). Average age at diagnosis was 57 years; however, two cases were under 20. The majority (62.5%) were male. Patients predominantly presented with epistaxis or nasal congestion (73%), while two cases were identified incidentally on radiological investigations. Twenty-seven cases underwent primary surgical management (two post neo-adjuvant treatment) with seventeen requiring bifrontal craniotomy. Twenty-four of these received postoperative radiation therapy. Overall, 5-year survival was 65%. Kadish A/B patients exhibited 100% 5-year disease-specific survival versus 54% in Kadish C/D (p = 0.011). Hyams grade I/II patients exhibited 75% 5-year disease-specific survival versus 63% in Hyams grade III/IV (p = 0.005). Patients treated endoscopically exhibited 100% 5-year disease-specific survival versus 51% in those treated via an open approach (p = 0.102). Conclusions Many controversies exist in the diagnosis and management of this condition. Despite this, results from Irish data are mostly concordant with the international literature. The rising incidence of this disease may represent improved pathological recognition. An increasing number of esthesioneuroblastoma cases are being successfully treated via endoscopic surgery.

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