With the rapid expansion of the campus scale and the increasing of the geographically dispersed campus, how to adopt new theory, new method and new technology to realize the equipment optimized assignment and the information management is a new research challenge. It is the key to safeguard the national fund to use reasonably, and to speed up the development of education healthily. Through analyzing the domestic and foreign related research works, the paper proposed that it can take use of the spatial data expression and analysis with Geographic Information System (GIS) to realize the large-scale and inter-campuses equipment optimized assignment and information management. It discussed the mathematics model and the system architecture. Moreover, the paper described the key implementation technology in great detail such as spatial data mapping with MapInfo professional 9 and the development of WebGIS functions with MapXtreme. The results show that the solution is feasible and effective.