Steep Discounting of Future Rewards as an Impulsivity Phenotype: A Concise Review

Background: Neglected tropical diseases (NTDs) affect a huge population of the world and majority of the victims belong to the poor community of the developing countries. Until now, the World Health Organization (WHO) has identified 20 tropical diseases as NTDs that must be addressed with high priority. However, many heterocyclic scaffolds have demonstrated potent therapeutic activity against several NTDs. Objective: There are three major objectives: (1) To discuss the causes, symptoms, and current status of all the 20 NTDs; (2) To explore the available heterocyclic drugs, and their mechanism of actions (if known) that are being used to treat NTDs; (3) To develop general awareness on NTDs among the medicinal/health research community and beyond. Methods: The 20 NTDs have been discussed according to their alphabetic orders along with the possible heterocyclic remedies. Current status of treatment with an emphasis on the heterocyclic drugs (commercially available and investigational) has been outlined. In addition, brief discussion of the impacts of NTDs on socio-economic condition is included. Results: NTDs are often difficult to diagnose and the problem is worsened by the unhealthy hygiene, improper awareness, and inadequate healthcare in the developing countries where these diseases primarily affect poor people. The statistics include duration of suffering, numbers affected, and access to healthcare and medication. The mechanism of actions of various heterocyclic drugs, if reported, have been briefly summarized. Conclusion: Scientists and pharmaceutical corporations should allocate more resources to reveal the in-depth mechanism of actions of many heterocyclic drugs that are currently being used for the treatment of NTDs. Analysis of current heterocyclic compounds and development of new medications can help in the fight to reduce/remove the devastating effects of NTDs. An opinion-based concise review has been presented. Based on available literature, this is the first effect to present all the 20 NTDs and related heterocyclic compounds under the same umbrella.

Download Full-text

Diverse thiophenes as scaffolds in anti-cancer drug development: A concise review

Mini-Reviews in Medicinal Chemistry ◽

10.2174/1389557520666201202113333 ◽

2020 ◽

Vol 20 ◽

Author(s):

Neha V. Bhilare ◽

Pratibha B. Auti ◽

Vinayak S. Marulkar ◽

Vilas J. Pise

Keyword(s):

Drug Development ◽

Anticancer Agents ◽

Heterocyclic Ring ◽

Biologically Active Compounds ◽

Biologically Active ◽

Cancer Drug ◽

Active Compounds ◽

Natural Origin ◽

Concise Review ◽

Anti Cancer

: Thiophenes are one among the abundantly found heterocyclic ring systems in many biologically active compounds. Moreover various substituted thiophenes exert numerous pharmacological actions on account of their isosteric resemblance with compounds of natural origin thus rendering them with diverse actions like antibacterial, antifungal, antiviral, anti-inflammatory, analgesic, antiallergic, hypotensives etc.. In this review we specifically explore the chemotherapeutic potential of variety of structures consisting of thiophene scaffolds as prospective anticancer agents.

Download Full-text

Concise Review: Recent Advances in Molecular Dynamics Simulation of Nanomachining of Metals

Current Nanoscience ◽

10.2174/1573413712666160527150038 ◽

2016 ◽

Vol 12 (6) ◽

pp. 653-665 ◽

Cited By ~ 2

Author(s):

Junjie Zhang ◽

Zhanfeng Wang ◽

Yongda Yan ◽

Tao Sun

Keyword(s):

Molecular Dynamics ◽

Molecular Dynamics Simulation ◽

Dynamics Simulation ◽

Concise Review ◽

Recent Advances

Download Full-text

Retinal Detachment

10.1093/oso/9780195330823.001.0001 ◽

2009 ◽

Author(s):

Daniel A. Brinton ◽

Charles P. Wilkinson

Keyword(s):

Graduate Students ◽

Retinal Detachment ◽

Historical Review ◽

Surgery Complications ◽

Preoperative Management ◽

Classic Article ◽

Concise Review ◽

Indirect Ophthalmoscopy ◽

Complications Of Surgery ◽

Preoperative Examination

Retinal Detachment: Principles and Practice provides a historical review of current information on the diagnosis and treatment of retinal detachment. It is intended as both an introduction for graduate students in ophthalmology and a concise review or reference for practicing ophthalmologists. The volume defines the types of retinal detachments, their classifications and causes, and covers preoperative examination, preoperative management, prophylactic procedures, surgery, complications of surgery, and results of reattachment surgery. It also includes a historical introduction, suggested readings at the end of each chapter, and the classic article 'The Technique of Binocular Indirect Ophthalmoscopy,' by Morten L. Rosenthal.

Download Full-text