scholarly journals Gastrointestinal Health in Classic Galactosemia

2016 ◽  
pp. 27-32 ◽  
Author(s):  
Kelly A. Shaw ◽  
Jennifer G. Mulle ◽  
Michael P. Epstein ◽  
Judith L. Fridovich-Keil
Keyword(s):  
Classic Galactosemia ◽  
Gastrointestinal Health

Probiotics for Gastrointestinal Health and�General�Wellbeing

2019 ◽  
Vol 15 (1) ◽  
pp. 22-29
Author(s):  
E.O. Irokanulo ◽  
M.A. Akalegbere
Keyword(s):  
Human Health ◽  
Low Income ◽  
Environmental Conditions ◽  
Mode Of Action ◽  
World Wide ◽  
Gut Flora ◽  
Gastrointestinal Infections ◽  
Gastrointestinal Health ◽  
Rural Settings ◽  
General Wellbeing

Gastrointestinal health is a precursor to general wellbeing in humans. Maintaining good normal gut flora for the health benefits they provide is important. Unfortunately, however, the good gut flora is sometimes dislodged during feeding and treatment with certain drugs. Foods that lead to such gut flora displacement may contain other microorganisms whose actions create unfavourable environmental conditions for resident flora. The principle of removing unwanted harmful gut flora; introducing good microorganisms through ingestion of live microorganisms, known as probiotics or foods that contain specific live microbes of interest is now practiced. Consumption of foods containing probiotics has long been practiced world-wide especially in rural settings and in low-income economies even though such consumptions may be unintended. Presently, careful isolation, characterization and testing of candidate probiotic organisms, has become the norm. This re-emerging phenomenon and the great impact it has on human health is considered here looking at probiotic sources; including foods, the role they play in gastrointestinal health, their mode of action and the disease types where they are beneficial to man including their safety and how their introduction in the �medical menu� in low-income nations can help in combating the rather very �regular� gastrointestinal infections in these countries.

Bowman-Birk Inhibitors from Legumes and Human Gastrointestinal Health: Current Status and Perspectives

2011 ◽  
Vol 12 (5) ◽  
pp. 358-373 ◽  
Author(s):  
Alfonso Clemente ◽  
Gabriella Sonnante ◽  
Claire Domoney
Keyword(s):  
Current Status ◽  
Gastrointestinal Health

scholarly journals Current and Future Treatments for Classic Galactosemia

2021 ◽  
Vol 11 (2) ◽  
pp. 75 ◽  
Author(s):  
Britt Delnoy ◽  
Ana I. Coelho ◽  
Maria Estela Rubio-Gozalbo
Keyword(s):  
Standard Of Care ◽  
Type I ◽  
Therapeutic Approaches ◽  
Restricted Diet ◽  
Galactose Metabolism ◽  
Galt Activity ◽  
Classic Galactosemia ◽  
Pathogenic Factors ◽  
Future Treatments ◽  
Novel Therapeutic

Type I (classic) galactosemia, galactose 1-phosphate uridylyltransferase (GALT)-deficiency is a hereditary disorder of galactose metabolism. The current therapeutic standard of care, a galactose-restricted diet, is effective in treating neonatal complications but is inadequate in preventing burdensome complications. The development of several animal models of classic galactosemia that (partly) mimic the biochemical and clinical phenotypes and the resolution of the crystal structure of GALT have provided important insights; however, precise pathophysiology remains to be elucidated. Novel therapeutic approaches currently being explored focus on several of the pathogenic factors that have been described, aiming to (i) restore GALT activity, (ii) influence the cascade of events and (iii) address the clinical picture. This review attempts to provide an overview on the latest advancements in therapy approaches.

Progressive worsening of central nervous system phenotype in children with classic galactosemia: a cross-sectional analysis

2021 ◽  
Vol 132 ◽  
pp. S7-S8
Author(s):  
Stella Wang ◽  
Francesca Lawson ◽  
Riccardo Perfetti ◽  
Shoshana Shendelman
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cross Sectional ◽  
Classic Galactosemia ◽  
Cross Sectional Analysis ◽  
Sectional Analysis

Hand fine motor control in classic galactosemia

2021 ◽  
Author(s):  
Jessica MacWilliams ◽  
Sneh Patel ◽  
Grace Carlock ◽  
Sarah Vest ◽  
Nancy L. Potter ◽  
...  
Keyword(s):  
Motor Control ◽  
Fine Motor ◽  
Fine Motor Control ◽  
Classic Galactosemia

scholarly journals Graded Dietary Resistant Starch Concentrations on Apparent Total Tract Macronutrient Digestibility and Fecal Fermentative End-Products and Microbial Populations of Healthy Adult Dogs

2020 ◽  
Author(s):  
Alison N Beloshapka ◽  
Tzu-Wen L Cross ◽  
Kelly S Swanson
Keyword(s):  
Resistant Starch ◽  
Healthy Adult ◽  
Latin Square ◽  
Basal Diet ◽  
Gastrointestinal Health ◽  
Beneficial Effects ◽  
Gross Energy ◽  
Quadratic Effects ◽  
Fecal Ph ◽  
High Level

Abstract Resistant starch (RS) is fermentable by gut microbiota and effectively modulates fecal short-chain fatty acid concentrations in pigs, mice, and humans. RS may have similar beneficial effects on the canine gut, but has not been well studied. The objective of this study was to evaluate the effects of 0, 1, 2, 3, and 4% dietary RS (Hi-maize 260) on apparent total tract macronutrient digestibility, and fecal characteristics, fermentative end-product concentrations, and microbiota of healthy adult dogs. An incomplete 5 x 5 Latin square design with 7 dogs and 5 experimental periods was used, with each treatment period lasting 21 d (d 0-17 adaptation; d 18-21 fresh and total fecal collection) and each dog serving as its own control. Seven dogs (mean age = 5.3 yr; mean BW = 20 kg) were randomly allotted to one of five treatments formulated to be iso-energetic and consisting of graded amounts of 100% amylopectin cornstarch, RS, and cellulose, and fed as a top dressing on the food each day. All dogs were fed the same amount of a basal diet throughout the study and fresh water was offered ad libitum. The basal diet contained 6.25% RS (DM basis), contributing approximately 18.3 g of RS/d based on their daily food intake (292.5 g DM/d). Data were evaluated for linear and quadratic effects using SAS. The treatments included 0%, 1%, 2%, 3%, and 4% of an additional RS source. Because Hi-maize 260 is approximately 40% digestible and 60% indigestible starch, the dogs received the following amounts of RS daily: 0% = 18.3 g (18.3 g + 0 g); 1% = 20.1 g (18.3 g + 1.8 g); 2% = 21.9 g (18.3 g + 3.6 g); 3% = 23.7 g (18.3 g + 5.4 g); and 4% = 25.5 g (18.3 g + 7.2 g). Apparent total tract dry matter, organic matter, crude protein, fat, and gross energy digestibilities and fecal pH were linearly decreased (P < 0.05) with increased RS consumption. Fecal output was linearly increased (P < 0.05) with increased RS consumption. Fecal scores and fecal fermentative end-product concentrations were not affected by RS consumption. Although most fecal microbial taxa were not altered, Faecalibacterium were increased (P < 0.05) with increased RS consumption. The decrease in fecal pH and increase in fecal Faecalibacterium would be viewed as being beneficial to gastrointestinal health. Although our results seem to indicate that RS is poorly and/or slowly fermentable in dogs, the lack of observed change may have been due to the rather high level of RS contained in the basal diet.

scholarly journals Impact of in vitro gastrointestinal digestion on the chemical composition, bioactive properties, and cytotoxicity of Vitis vinifera L. cv. Syrah grape pomace extract

2019 ◽  
Vol 10 (4) ◽  
pp. 1856-1869 ◽  
Author(s):  
Joana R. Costa ◽  
Manuela Amorim ◽  
Ana Vilas-Boas ◽  
Renata V. Tonon ◽  
Lourdes M. C. Cabral ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Phenolic Compounds ◽  
Vitis Vinifera ◽  
Human Health ◽  
Grape Pomace ◽  
Vitis Vinifera L ◽  
Gastrointestinal Digestion ◽  
Gastrointestinal Health ◽  
Bioactive Properties

Grape pomace (GP) is a major byproduct worldwide, and it is well known for its bioactive compounds, such as fibers and phenolic compounds, that are popular for their impact upon human health, including in gastrointestinal health.

Biological activities of selected polyphenol-rich fruits related to immunity and gastrointestinal health

2014 ◽  
Vol 157 ◽  
pp. 37-44 ◽  
Author(s):  
Petko Denev ◽  
Maria Kratchanova ◽  
Milan Ciz ◽  
Antonin Lojek ◽  
Ondrej Vasicek ◽  
...  
Keyword(s):  
Biological Activities ◽  
Gastrointestinal Health

scholarly journals Gut microbiota in early life and its influence on health and disease: A position paper by the Malaysian Working Group on Gastrointestinal Health

2017 ◽  
Vol 53 (12) ◽  
pp. 1152-1158 ◽  
Author(s):  
Yeong Yeh Lee ◽  
Siti Asma Hassan ◽  
Intan Hakimah Ismail ◽  
Sze Yee Chong ◽  
Raja Affendi Raja Ali ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Early Life ◽  
Working Group ◽  
Position Paper ◽  
Gastrointestinal Health ◽  
Health And Disease
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