scholarly journals Evaluation of Activation and Inflammatory Activity of Myeloid Cells During Pathogenic Human Coronavirus Infection

2019 ◽  
pp. 195-204 ◽  
Author(s):  
Rudragouda Channappanavar ◽  
Stanley Perlman
Keyword(s):  
Myeloid Cells ◽  
Inflammatory Activity ◽  
Human Coronavirus ◽  
Coronavirus Infection

scholarly journals Virus-Negative Myopericarditis in Human Coronavirus Infection

2020 ◽  
Vol 13 (11) ◽  
Author(s):  
Franca del Nonno ◽  
Andrea Frustaci ◽  
Romina Verardo ◽  
Cristina Chimenti ◽  
Emanuele Nicastri ◽  
...  
Keyword(s):  
Human Coronavirus ◽  
Coronavirus Infection

scholarly journals Human Coronavirus Infection among Children with Acute Lower Respiratory Tract Infection in Thailand

Intervirology ◽  
2006 ◽  
Vol 50 (2) ◽  
pp. 71-77 ◽  
Author(s):  
Apiradee Theamboonlers ◽  
Rujipat Samransamruajkit ◽  
Chittima Thongme ◽  
Alongkorn Amonsin ◽  
Voranush Chongsrisawat ◽  
...  
Keyword(s):  
Tract Infection ◽  
Respiratory Tract ◽  
Respiratory Tract Infection ◽  
Lower Respiratory Tract Infection ◽  
Lower Respiratory Tract ◽  
Human Coronavirus ◽  
Coronavirus Infection

scholarly journals The La ribonucleoprotein domain family member 6, LARP6 is differentially expressed and transcriptionally induced in models of coronavirus infection.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Family Member ◽  
Cellular Response ◽  
Differentially Expressed Gene ◽  
Differentially Expressed ◽  
Domain Family ◽  
Human Coronavirus ◽  
Lack Of Information ◽  
Infection Models ◽  
Mammalian Tissues ◽  
Coronavirus Infection

The coronavirus COVID19 pandemic is an emerging biosafety threat to the nation and the world (1). There are no treatments approved for coronavirus infection in humans (2) and there is a lack of information available regarding the basic transcriptional behavior of human cells and mammalian tissues following coronavirus infection. We mined two independent datasets (3, 4), public (3) and published (4) containing transcriptome data from infection models of the Middle East respiratory syndrome (MERS) coronavirus and human coronavirus (HCoV) to discover genes that are differentially expressed in coronaviruses and identify potential therapeutic targets and host cell vulnerabilities. We identified the La ribonucleoprotein domain family member 6 (LARP6) as a conserved differentially expressed gene following coronavirus infection. LARP6 may be involved in the cellular response to COVID19 infection.

scholarly journals Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Wayne Vuong ◽  
Muhammad Bashir Khan ◽  
Conrad Fischer ◽  
Elena Arutyunova ◽  
Tess Lamer ◽  
...  
Keyword(s):  
Drug Target ◽  
Covalent Modification ◽  
Human Coronavirus ◽  
Feline Infectious Peritonitis ◽  
Drug Candidates ◽  
Main Protease ◽  
Coronavirus Infection ◽  
Reversible Formation ◽  
Nanomolar Range ◽  
Feline Coronavirus

Abstract The main protease, Mpro (or 3CLpro) in SARS-CoV-2 is a viable drug target because of its essential role in the cleavage of the virus polypeptide. Feline infectious peritonitis, a fatal coronavirus infection in cats, was successfully treated previously with a prodrug GC376, a dipeptide-based protease inhibitor. Here, we show the prodrug and its parent GC373, are effective inhibitors of the Mpro from both SARS-CoV and SARS-CoV-2 with IC50 values in the nanomolar range. Crystal structures of SARS-CoV-2 Mpro with these inhibitors have a covalent modification of the nucleophilic Cys145. NMR analysis reveals that inhibition proceeds via reversible formation of a hemithioacetal. GC373 and GC376 are potent inhibitors of SARS-CoV-2 replication in cell culture. They are strong drug candidates for the treatment of human coronavirus infections because they have already been successful in animals. The work here lays the framework for their use in human trials for the treatment of COVID-19.

scholarly journals Strain-Specific Clinical Characteristics of Human Coronavirus Infection Among Adolescents and Adults With Influenza-Like Illness

2015 ◽  
Vol 2 (suppl_1) ◽  
Author(s):  
Monique Bouvier ◽  
John Arnold ◽  
Wei-Ju Chen ◽  
Mary Fairchok ◽  
Christina Schofield ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Human Coronavirus ◽  
Influenza Like Illness ◽  
Adolescents And Adults ◽  
Coronavirus Infection

scholarly journals IL6 and IL1RN is differentially expressed and transcriptionally induced in models of SARS coronavirus infection.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Cellular Response ◽  
Differentially Expressed ◽  
Transcriptome Data ◽  
Sars Coronavirus ◽  
Human Coronavirus ◽  
Lack Of Information ◽  
Infection Models ◽  
Mammalian Tissues ◽  
Coronavirus Infection ◽  
Human Coronavirus 229E

The coronavirus COVID19 pandemic is an emerging biosafety threat to the nation and the world (1). There are no treatments approved for coronavirus infection in humans (2) and there is a lack of information available regarding the basic transcriptional behavior of human cells and mammalian tissues following coronavirus infection. We mined independent published (3-5) and public (6) datasets, containing transcriptome data from infection models of the human coronavirus 229E and of severe acute respiratory syndrome (SARS) coronavirus to discover genes that are differentially expressed in coronaviruses and identify potential therapeutic targets and host cell vulnerabilities. We identified IL6 and IL1RN as conserved differentially expressed genes following coronavirus infection. IL6 and IL1RN may be involved in the cellular response to COVID19 infection.

scholarly journals The phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase, PAICS, is differentially expressed following infection by the coronavirus family.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Transcriptional Repression ◽  
De Novo ◽  
Human Cells ◽  
Human Coronavirus ◽  
Significant Differential Expression ◽  
Purine Synthesis ◽  
Transcriptional Modulation ◽  
Coronavirus Infection ◽  
Microarray Datasets

We mined published and public microarray datasets (1-6) to discover conserved host cell machinery transcriptionally modulated by the coronavirus family. We found significant differential expression and transcriptional repression of a gene utilized during de novo purine synthesis, PAICS, following infection of human cells with the Middle East Respiratory Syndrome (MERS) coronavirus in vitro, in the lungs of mice following infection with the Severe Acute Respiratory Syndrome (SARS) coronavirus 1 (SARS-CoV-1), in the blood and lungs of ferrets following intranasal infection with SARS-CoV-1, but not in human cells infected with the human coronavirus HCoV-229E. These data indicate transcriptional modulation of de novo purine synthesis pathways by viruses of the coronavirus family or during coronavirus infection.

scholarly journals Viral co-infections are associated with dysregulation of HLA family gene expression.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Gene Expression ◽  
Influenza A ◽  
Microarray Dataset ◽  
Human Coronavirus ◽  
Significant Differential Expression ◽  
A Cell ◽  
Family Gene ◽  
Coronavirus Infection ◽  
Syncytial Virus ◽  
One Year

Co-infection is a process by which a cell or organism already infected with a virus is then infected with a second, different virus (1, 2). The human coronavirus SARS-CoV-2 has resulted in the death of nearly 200,000 Americans in less than one year (3, 4); the upcoming influenza could potentially pose a problem with respect to co-infection with Influenza and SARS-CoV-2; significant co-infection in patients with SARS-CoV-2 has been reported (5). We mined a published microarray dataset (6) to discover genes associated with viral co-infection in patients with a coronavirus infection. We found that genes of the HLA family, particularly HLA-DRB and HLA-A, were significantly differentially expressed in the blood of patients with human coronavirus infections, including HCoV-229E, HCoV OC43, HCoV NL63, and HCoV HKU1. Different viral co-infections, including Influenza A, Human Rhinovirus, Enterovirus, and Respiratory Syncytial Virus A co-infections were also associated with significant differential expression of HLA family genes in patient blood. Perturbation of HLA family gene expression appears to be a general feature of viral co-infection in humans.

scholarly journals TRIB1 is differentially expressed and transcriptionally induced in models of coronavirus infection.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Cellular Response ◽  
Differentially Expressed Gene ◽  
Differentially Expressed ◽  
Transcriptome Data ◽  
Human Coronavirus ◽  
Lack Of Information ◽  
Infection Models ◽  
Mammalian Tissues ◽  
The World ◽  
Coronavirus Infection

The coronavirus COVID19 pandemic is an emerging biosafety threat to the nation and the world (1). There are no treatments approved for coronavirus infection in humans (2) and there is a lack of information available regarding the basic transcriptional behavior of human cells and mammalian tissues following coronavirus infection. We mined two independent datasets (3, 4), public (3) and published (4) containing transcriptome data from infection models of the Middle East respiratory syndrome (MERS) coronavirus and human coronavirus (HCoV) to discover genes that are differentially expressed in coronaviruses and identify potential therapeutic targets and host cell vulnerabilities. We identified tribbles homolog 1, TRIB1 as a conserved differentially expressed gene following coronavirus infection. TRIB1 may be involved in the cellular response to COVID19 infection.

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