Clinical Effects and Interactions of the Non-Steroidal Anti-Inflammatory Drugs

1980 ◽  
pp. 288-297
Author(s):  
P. M. Brooks
Keyword(s):  
Clinical Effects ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Clinical Effects of the Extract of the Seeds of the Indian Celery—Apium graveolens—In Horses Affected by Chronic Osteoarthritis

Animals ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. 585
Author(s):  
Beatrice Battaglia ◽  
Mario Angelone ◽  
Elena Vera ◽  
Giuseppina Basini ◽  
Simona Bussolati ◽  
...  
Keyword(s):  
Vital Signs ◽  
Apium Graveolens ◽  
Clinical Effects ◽  
Clinical Parameters ◽  
Blood Samples ◽  
Passive Flexion ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Potential Use ◽  
Flexion Test

The extract of the seeds from Indian celery, Apium greaveolens (CSE), tested in experimental animals (rodents), and in humans affected by chronic osteoarthritic diseases, exhibits anti-inflammatory effects that can be compared, to some degree, to those of non-steroid anti-inflammatory drugs (NSAID). In view of a potential use of CSE in the equine species, it was tested on horses affected by chronic articular pathologies. The trial was performed on 20 horses divided into three different groups, orally treated with 0 (controls), 7.0 or 30 g of CSE BID. Basic orthopedic examinations were conducted, vital signs were observed, and blood samples collected. Improvement was observed at the highest dosage tested (30 g of CSE BID), as reflected in the score values of three clinical parameters, (i) amplitude and (ii) sensitivity to passive flexion and (iii) flexion test. Since the improvement of these parameters can be correlated with a lower perception of the pain, the present data suggest that the CSE treatment can have an analgesic effect in horses affected by chronic osteoarthritic diseases.

scholarly journals Application of pulse magnetotherapy in integrated treatment of patients with gonartrosis

2020 ◽  
Author(s):  
Marina Yu. Gerasimenko Gerasimenko
Keyword(s):  
Magnetic Field ◽  
Integrated Treatment ◽  
Stage I ◽  
Pulsed Magnetic Field ◽  
Joint Disease ◽  
Clinical Effects ◽  
Complex Treatment ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Arthrosis is the most common joint disease in adults worldwide. Its incidence increases with age. In this study, the effectiveness of complex treatment was studied in 50 patients with an established diagnosis of stage I - III knee osteoarthrosis. All patients are non-steroidal anti-inflammatory drugs. Running along a pulsed magnetic field in the area of ​​the affected joint. The obtained clinical effects indicate the advisability of including magnetotherapy procedures in the treatment complex.

scholarly journals STW1 and Its Versatile Pharmacological and Clinical Effects in Rheumatic Disorders: A Comprehensive Report

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Karl-Josef Gundermann ◽  
Jürgen Müller ◽  
Karin Kraft
Keyword(s):  
Rheumatic Diseases ◽  
Safety Profile ◽  
Comparable Efficacy ◽  
Inflammatory Rheumatic Diseases ◽  
Clinical Effects ◽  
Double Blind ◽  
Solidago Virgaurea ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
The Individual

Aim. To review the published and unpublished experimental and clinical studies about the efficacy and tolerability of STW1 and to compare the results to the efficacy and tolerability of investigated NSAIDs in parallel. Content. STW1 (Phytodolor®) contains a fixed combination of extracts from aspen leaves and bark (Populus tremula), common ash bark (Fraxinus excelsior), and goldenrod herb (Solidago virgaurea). It belongs to the group of anti-inflammatory and antirheumatic drugs, and it is authorized for the treatment of painful disorders of degenerative and inflammatory rheumatic diseases. The individual components have complementary effects. Its multifocal mode of action includes antiphlogistic, analgesic, antiexudative, antioxidative, antipyretic, and antiproliferative properties. The effects of both STW1 and its components have been verified in comprehensive pharmacological investigations. Open and randomized, placebo- and verum-controlled, and single-blind (sb) or double-blind (db) clinical trials, performed in different subtypes of rheumatic diseases confirm the pharmacological evidence. Its efficacy is comparable to a range of standard nonsteroidal anti-inflammatory drugs (NSAIDs) studied in parallel, but it has a superior safety profile. Conclusion. STW1 is a reasonable alternative to NSAIDs with comparable efficacy and a superior safety profile. It is also suitable to reduce the intake of NSAIDs.

Polyphenols from Cymbopogon citratus inhibit iNOS expression and NO production – a promising source of new anti-inflammatory drugs

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
V Francisco ◽  
A Figueirinha ◽  
B Neves ◽  
C Garcia-Rodriguez ◽  
M Lopes ◽  
...  
Keyword(s):  
Inos Expression ◽  
No Production ◽  
Cymbopogon Citratus ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Promising Source

Heparin and proteoglycans as anti-inflammatory drugs

1996 ◽  
Vol 16 (01) ◽  
pp. 56-59
Author(s):  
D. J. Tyrrell ◽  
C. P. Page
Keyword(s):  
Inflammatory Diseases ◽  
Therapeutic Applications ◽  
Wide Range ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

SummaryEvidence continues to accumulate that the pleiotropic nature of heparin (beyond its anticoagulant potency) includes anti-inflammatory activities at a number of levels. It is clear that drugs exploiting these anti-inflammatory activities of heparin may offer exciting new therapeutic applications to the treatment of a wide range of inflammatory diseases.

Non-Steroidal Anti-inflammatory Drugs (NSAIDs): Synthesis of Ibuprofen, Naproxen and Nabumetone

2019 ◽  
pp. 19-27
Keyword(s):  
Review Paper ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Synthetic Approaches

This review paper covers the major synthetic approaches attempted towards the synthesis of some Non-Steroidal Anti-Inflammatory Drugs (Naproxen, Ibuprofen and Nabumetone)

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