High resolution localization of recombination hot spots using sperm typing

1994 ◽  
Vol 7 (3) ◽  
pp. 420-424 ◽  
Author(s):  
Rene Hubert ◽  
Marcy MacDonald ◽  
James Gusella ◽  
Norman Arnheim
Keyword(s):  
High Resolution ◽  
Hot Spots ◽  
Recombination Hot Spots ◽  
Sperm Typing

Ordering three microsatellites on porcine chromosome 12 by single sperm typing

2000 ◽  
Vol 11 (1) ◽  
pp. 45-49 ◽  
Author(s):  
S. Zhao ◽  
K. Li ◽  
M. Yu ◽  
Z. Peng
Keyword(s):  
Chromosome 12 ◽  
Porcine Chromosome ◽  
Sperm Typing

Order of bovine DRB3, DYA, and PRL determined by sperm typing

1993 ◽  
Vol 4 (2) ◽  
pp. 113-118 ◽  
Author(s):  
Michiel J. T. van Eijk ◽  
Ingolf Russ ◽  
Harris A. Lewin
Keyword(s):  
Sperm Typing

Sperm typing allows accurate measurement of the recombination fraction between D3S2 and D3S3 on the short arm of human chromosome 3

Genomics ◽  
1992 ◽  
Vol 12 (4) ◽  
pp. 683-687 ◽  
Author(s):  
Rene Hubert ◽  
Vincent P. Stanton ◽  
Hiroyuki Aburatani ◽  
John Warren ◽  
Honghua Li ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Recombination Fraction ◽  
Chromosome 3 ◽  
Human Chromosome 3 ◽  
Sperm Typing

scholarly journals Meiotic recombination hot spots and human DNA diversity

2004 ◽  
Vol 359 (1441) ◽  
pp. 141-152 ◽  
Author(s):  
Alec J. Jeffreys ◽  
J. Kim Holloway ◽  
Liisa Kauppi ◽  
Celia A. May ◽  
Rita Neumann ◽  
...  
Keyword(s):  
Human Genome ◽  
Meiotic Recombination ◽  
Hot Spots ◽  
Haplotype Diversity ◽  
Mendelian Inheritance ◽  
Human Diversity ◽  
Fundamental Information ◽  
Recombination Hot Spots ◽  
Sperm Typing ◽  
Very High

Meiotic recombination plays a key role in the maintenance of sequence diversity in the human genome. However, little is known about the fine–scale distribution and processes of recombination in human chromosomes, or how these impact on patterns of human diversity. We have therefore developed sperm typing systems that allow human recombination to be analysed at very high resolution. The emerging picture is that human crossovers are far from randomly distributed but instead are targeted into very narrow hot spots that can profoundly influence patterns of haplotype diversity in the human genome. These hot spots provide fundamental information on processes of human crossover and gene conversion, as well as evidence that they can violate basic rules of Mendelian inheritance.

scholarly journals Meiotic Segregation Analysis of RB1 Alleles in Retinoblastoma Pedigrees by Use of Single-Sperm Typing

2000 ◽  
Vol 66 (1) ◽  
pp. 167-175 ◽  
Author(s):  
Anne Girardet ◽  
Mary Sara McPeek ◽  
Esther P. Leeflang ◽  
Francis Munier ◽  
Norman Arnheim ◽  
...  
Keyword(s):  
Segregation Analysis ◽  
Meiotic Segregation ◽  
Sperm Typing
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