Dual Role of Nitric Oxide in Cancer Biology

2010 ◽  
pp. 39-57 ◽  
Author(s):  
Shehla Pervin ◽  
Rajan Singh ◽  
Suvajit Sen ◽  
Gautam Chaudhuri
Keyword(s):  
Nitric Oxide ◽  
Cancer Biology ◽  
Dual Role

Dual Role of Nitric Oxide in the Pathogenesis of Parkinson's Disease

2014 ◽  
Vol 1 (4) ◽  
pp. 243-253 ◽  
Author(s):  
Vaibhav Walia ◽  
Anuradha Sharma ◽  
Monika Gahlawat ◽  
O. P. Dube
Keyword(s):  
Nitric Oxide ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dual Role

The Dual Role of Nitric Oxide in Glioma

2010 ◽  
Vol 16 (4) ◽  
pp. 428-430 ◽  
Author(s):  
Wiaam Badn ◽  
Peter Siesjo
Keyword(s):  
Nitric Oxide ◽  
Dual Role

Dual role of inducible nitric oxide synthase in acute asbestos-induced lung injury

2002 ◽  
Vol 33 (4) ◽  
pp. 491-501 ◽  
Author(s):  
Martina Dörger ◽  
Anne-Marie Allmeling ◽  
Rainer Kiefmann ◽  
Alke Schropp ◽  
Fritz Krombach
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Lung Injury ◽  
Inducible Nitric Oxide Synthase ◽  
Dual Role ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Exploiting S-nitrosylation for cancer therapy: facts and perspectives

2020 ◽  
Vol 477 (19) ◽  
pp. 3649-3672
Author(s):  
Salvatore Rizza ◽  
Giuseppe Filomeni
Keyword(s):  
Nitric Oxide ◽  
Cancer Biology ◽  
Synthetic Lethality ◽  
Current Knowledge ◽  
Tissue Homeostasis ◽  
Loss Of Function ◽  
Post Translational Modification ◽  
Cellular Processes ◽  
Insight Into

S-nitrosylation, the post-translational modification of cysteines by nitric oxide, has been implicated in several cellular processes and tissue homeostasis. As a result, alterations in the mechanisms controlling the levels of S-nitrosylated proteins have been found in pathological states. In the last few years, a role in cancer has been proposed, supported by the evidence that various oncoproteins undergo gain- or loss-of-function modifications upon S-nitrosylation. Here, we aim at providing insight into the current knowledge about the role of S-nitrosylation in different aspects of cancer biology and report the main anticancer strategies based on: (i) reducing S-nitrosylation-mediated oncogenic effects, (ii) boosting S-nitrosylation to stimulate cell death, (iii) exploiting S-nitrosylation through synthetic lethality.

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