Crosstalk of Ceramide with Cell Survival Signaling

2002 ◽  
pp. 91-99 ◽  
Author(s):  
Toshiro Okazaki ◽  
Tadakazu Kondo ◽  
Mitsumasa Watanabe ◽  
Yoshimitsu Taguchi ◽  
Takeshi Yabu
Keyword(s):  
Cell Survival ◽  
Survival Signaling

scholarly journals 4-Hydroxy-3-Methoxybenzoic Acid Methyl Ester: A Curcumin Derivative Targets Akt/NFκB Cell Survival Signaling Pathway: Potential for Prostate Cancer Management

Neoplasia ◽  
2003 ◽  
Vol 5 (3) ◽  
pp. 255-266 ◽  
Author(s):  
Addanki P. Kumar ◽  
Gretchen E. Garcia ◽  
Rita Ghosh ◽  
Rajendran V. Rajnarayanan ◽  
William L. Alworth ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Methyl Ester ◽  
Cell Survival ◽  
Acid Methyl Ester ◽  
Cancer Management ◽  
Acid Methyl ◽  
Survival Signaling ◽  
Prostate Cancer Management ◽  
Curcumin Derivative ◽  
Methoxybenzoic Acid

p70s6 kinase is a functional target of insulin activated Akt cell-survival signaling

2004 ◽  
Vol 315 (1) ◽  
pp. 160-165 ◽  
Author(s):  
Anne K Jonassen ◽  
Ole D Mjøs ◽  
Michael N Sack
Keyword(s):  
Cell Survival ◽  
P70s6 Kinase ◽  
Survival Signaling

Postnatal shifts in ischemic tolerance and cell survival signaling in murine myocardium

2013 ◽  
Vol 305 (10) ◽  
pp. R1171-R1181 ◽  
Author(s):  
Norman Y. Liaw ◽  
Louise See Hoe ◽  
Freya L. Sheeran ◽  
Jason N. Peart ◽  
John P. Headrick ◽  
...  
Keyword(s):  
Cell Survival ◽  
Connexin 43 ◽  
Glycogen Synthase ◽  
Ischemia Reperfusion ◽  
Hypoxia Inducible Factor ◽  
High Expression ◽  
Hsp27 Phosphorylation ◽  
Myocardial Stress ◽  
Survival Signaling ◽  
Gsk 3Β

The immature heart is known to be resistant to ischemia-reperfusion (I/R) injury; however, key proteins engaged in phospho-dependent signaling pathways crucial to cell survival are not yet defined. Our goal was to determine the postnatal changes in myocardial tolerance to I/R, including baseline expression of key proteins governing I/R tolerance and their phosphorylation during I/R. Hearts from male C57Bl/6 mice (neonates, 2, 4, 8, and 12 wk of age, n = 6/group) were assayed for survival signaling/effectors [Akt, p38MAPK, glycogen synthase kinase-3β (GSK-3β), heat shock protein 27 (HSP27), connexin-43, hypoxia-inducible factor-1α (HIF-1α), and caveolin-3] and regulators of apoptosis (Bax and Bcl-2) and autophagy (LC3B, Parkin, and Beclin1). The effect of I/R on ventricular function was measured in isolated perfused hearts from immature (4 wk) and adult (12 wk) mice. The neonatal myocardium exhibits a large pool of inactive Akt; high phospho-activation of p38MAPK, HSP27 and connexin-43; phospho-inhibition of GSK-3β; and high expression of caveolin-3, HIF-1α, LC3B, Beclin1, Bax, and Bcl-2. Immature hearts sustained less dysfunction and infarction following I/R than adults. Emergence of I/R intolerance in adult vs. immature hearts was associated with complex proteomic changes: decreased expression of Akt, Bax, and Bcl-2; increased GSK-3β, connexin-43, HIF-1α, LC3B, and Bax:Bcl-2; enhanced postischemic HIF-1α, caveolin-3, Bax, and Bcl-2; and greater postischemic GSK-3β and HSP27 phosphorylation. Neonatal myocardial stress resistance reflects high expression of prosurvival and autophagy proteins and apoptotic regulators. Notably, there is high phosphorylation of GSK-3β, p38MAPK, and HSP27 and low phosphorylation of Akt (high Akt “reserve”). Subsequent maturation-related reductions in I/R tolerance are associated with reductions in Akt, Bcl-2, LC3B, and Beclin1, despite increased expression and reduced phospho-inhibition of GSK-3β.

Norepinephrine and nitric oxide promote cell survival signaling in hippocampal neurons

2010 ◽  
Vol 633 (1-3) ◽  
pp. 1-9 ◽  
Author(s):  
Neha J. Patel ◽  
Michael J. Chen ◽  
Amelia A. Russo-Neustadt
Keyword(s):  
Nitric Oxide ◽  
Cell Survival ◽  
Hippocampal Neurons ◽  
Promote Cell Survival ◽  
Survival Signaling

Chemo-Immunosensitization of Resistant B-NHL as a Result of Rituximab (anti-CD20 mAb)-Mediated Inhibition of Cell Survival Signaling Pathways

2008 ◽  
pp. 29-39
Author(s):  
Benjamin Bonavida ◽  
Ali R. Jazirehi ◽  
Mario I. Vega ◽  
Sara Huerta-Yepez ◽  
Kazuo Umezawa ◽  
...  
Keyword(s):  
Cell Survival ◽  
Signaling Pathways ◽  
Survival Signaling ◽  
Anti Cd20

The beneficial effects of Zn on Akt-mediated insulin and cell survival signaling pathways in diabetes

2018 ◽  
Vol 46 ◽  
pp. 117-127 ◽  
Author(s):  
Weixia Sun ◽  
Jiaxing Yang ◽  
Wanning Wang ◽  
Jie Hou ◽  
Yanli Cheng ◽  
...  
Keyword(s):  
Cell Survival ◽  
Signaling Pathways ◽  
Beneficial Effects ◽  
Survival Signaling
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