Intermittent Hypoxia in Treatment of Bronchial Asthma in Childhood

2012 ◽  
pp. 135-143 ◽  
Author(s):  
Tatiana V. Serebrovskaya ◽  
Alexander N. Bakunovsky ◽  
Klaudia V. Nesvitailova ◽  
Iryna N. Mankovska
Keyword(s):  
Bronchial Asthma ◽  
Intermittent Hypoxia

scholarly journals Impaired Interhemispheric Synchrony in Bronchial Asthma

2021 ◽  
Author(s):  
Ya-Jun Wu ◽  
Jie Rao ◽  
Xin Huang ◽  
Na Wu ◽  
Ling Shi ◽  
...  
Keyword(s):  
Basal Ganglia ◽  
Functional Connectivity ◽  
Bronchial Asthma ◽  
Resting State ◽  
Intermittent Hypoxia ◽  
Resting State Functional Connectivity ◽  
Brain Areas ◽  
Lingual Gyrus ◽  
Postcentral Gyrus ◽  
Asthma Patients

Abstract Objective: Converging evidence demonstrated that bronchial asthma (BA) individuals with intermittent hypoxia were associated with functional and morphological reorganization in the brain. However, the alterations of the interhemispheric functional connectivity in BA individuals remain unknown. The purpose of this study was to assess the interhemispheric functional connectivity changes in individuals with intermittent hypoxia due to BA using voxel-mirrored homotopic connectivity (VMHC) methods.Methods: In total, 31 BA individuals (17 males and 14 females) and 30 healthy controls (HCs) (15 males and 15 females) closely matched in age, sex, and education underwent resting-state magnetic resonance imaging (MRI) scans. VMHC analysis was performed to investigate differences in interhemispheric functional connectivity between the two groups. Then, a seed-based resting-state functional connectivity (rsFC) analysis was conducted to further reveal the abnormal functional connectivity between the altered VMHC regions and the whole brain. Results: Compared with HCs, BA individuals had significantly lower VMHC values in the bilateral basal ganglia/thalamus/insula, cuneus/calcarine/lingual gyrus [brodmann area (BA) 17/18/19], precentral and postcentral gyrus (BA 3/4/6).[voxel level P<0.01, Gaussian random field (GRF) correction, cluster level P < 0.05]. Taking VMHC altered brain areas as seed points, the rsFC values of left insula/supramarginal/postcentral gyrus (PostCG) / inferior parietal lobule (IPL) brain areas in BA patients were increased, and rsFC values of right basic ganglia / thalamus, left caudate/antioxidant cingulate and bilateral cuneus/calcarine/lingual gyrus/precentral gyrus (PreCG)/PostCG were decreased in BA patients.Conclusion: The abnormal resting-state functional connectivity of BA patients is altered in specific brain regions related to the basal ganglia network, visual network, and sensorimotor network, which may be related to the neuropathogenesis of asthma patients. Furthermore, these VMHC and FC values may be important clinical indicators for the diagnosis and treatment of asthma patients.

Pathogenesis of Bronchial Asthma

1950 ◽  
Vol 34 (6) ◽  
pp. 1829-1838 ◽  
Author(s):  
John J. Curry
Keyword(s):  
Bronchial Asthma

Aeroallergens inducing bronchial asthma (BA) in Belarus

1997 ◽  
Vol 56 (1-3) ◽  
pp. 186
Author(s):  
E Dotsenko
Keyword(s):  
Bronchial Asthma

Atopic dermatitis: new horizons of therapy

2019 ◽  
Vol 1 (7) ◽  
pp. 29-32 ◽  
Author(s):  
L. S. Kruglova ◽  
E. M. Gensler
Keyword(s):  
Blood Pressure ◽  
Immune Response ◽  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Targeted Therapy ◽  
Inflammatory Response ◽  
Bronchial Asthma ◽  
New Horizons ◽  
The Past

Over the past decades, the first breakthrough milestone in the treatment of severe forms of atopic dermatitis (AD) has been targeted therapy aimed at inhibiting IL-4 and IL-13. This was made possible thanks to advances in the understanding of the pathogenesis of AD, the driver of which is the Th2-type immune response, which also underlies such manifestations of atopy as bronchial asthma, allergic rhinitis, and polynosis. In the case of the Th2-type immune response, cytokines IL-4 and IL-13 are secreted, which are the main promoters of the inflammatory response in AD. Inhibition of IL-4 and IL-13 leads to the prevention of inflammation and is an effective approach to therapy. The use of therapy aimed at inhibition of cytokines allows you to effectively cope with the manifestations of severe and moderately severe blood pressure.

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