Pulmonary Hemorrhage Syndromes

1999 ◽  
pp. 357-376
Author(s):  
Teofilo L. Lee-Chiong ◽  
Anne McB. Curtis ◽  
Richard A. Matthay
Keyword(s):  
Pulmonary Hemorrhage

An Unusual Case of Pulmonary Hemorrhage in a Term Neonate without Any Specific Risk Factor

2019 ◽  
Author(s):  
F. Prato ◽  
G. Genoni ◽  
R. Broglia Franchin ◽  
C. Vivenza ◽  
B. Loperfido ◽  
...  
Keyword(s):  
Risk Factor ◽  
Unusual Case ◽  
Pulmonary Hemorrhage ◽  
Term Neonate ◽  
Specific Risk Factor ◽  
Specific Risk

scholarly journals Treatment with senicapoc in a porcine model of acute respiratory distress syndrome

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Asbjørn G. Petersen ◽  
Peter C. Lind ◽  
Anne-Sophie B. Jensen ◽  
Mark A. Eggertsen ◽  
Asger Granfeldt ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Lung Injury ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Bronchoalveolar Lavage ◽  
Primary Endpoint ◽  
Bronchoalveolar Lavage Fluid ◽  
Distress Syndrome ◽  
Pulmonary Hemorrhage ◽  
Lavage Fluid

Abstract Background Senicapoc is a potent and selective blocker of KCa3.1, a calcium-activated potassium channel of intermediate conductance. In the present study, we investigated whether there is a beneficial effect of senicapoc in a large animal model of acute respiratory distress syndrome (ARDS). The primary end point was the PaO2/FiO2 ratio. Methods ARDS was induced in female pigs (42–49 kg) by repeated lung lavages followed by injurious mechanical ventilation. Animals were then randomly assigned to vehicle (n = 9) or intravenous senicapoc (10 mg, n = 9) and received lung-protective ventilation for 6 h. Results Final senicapoc plasma concentrations were 67 ± 18 nM (n = 9). Senicapoc failed to change the primary endpoint PaO2/FiO2 ratio (senicapoc, 133 ± 23 mmHg; vehicle, 149 ± 68 mmHg). Lung compliance remained similar in the two groups. Senicapoc reduced the level of white blood cells and neutrophils, while the proinflammatory cytokines TNFα, IL-1β, and IL-6 in the bronchoalveolar lavage fluid were unaltered 6 h after induction of the lung injury. Senicapoc-treatment reduced the level of neutrophils in the alveolar space but with no difference between groups in the cumulative lung injury score. Histological analysis of pulmonary hemorrhage indicated a positive effect of senicapoc on alveolar–capillary barrier function, but this was not supported by measurements of albumin content and total protein in the bronchoalveolar lavage fluid. Conclusions In summary, senicapoc failed to improve the primary endpoint PaO2/FiO2 ratio, but reduced pulmonary hemorrhage and the influx of neutrophils into the lung. These findings open the perspective that blocking KCa3.1 channels is a potential treatment to reduce alveolar neutrophil accumulation and improve long-term outcome in ARDS.

scholarly journals Assessment of the pulmonary adaptive immune response to Cladosporium cladosporioides infection using an experimental mouse model

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xiaoping Ma ◽  
Jing Hu ◽  
Yan Yu ◽  
Chengdong Wang ◽  
Yu Gu ◽  
...  
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Adaptive Immune Response ◽  
Pulmonary Hemorrhage ◽  
Cladosporium Cladosporioides ◽  
Th2 Cells ◽  
Intercellular Adhesion Molecule ◽  
Post Inoculation ◽  
Adaptive Immune ◽  
Systemic Infections

AbstractCladosporium cladosporioides causes asthma and superficial and deep infections, mostly in immunodeficient individuals and animals. This study aimed to investigate whether C. cladosporioides spores can enter the lungs through pulmonary circulation and influence pulmonary immune response. We intravenously injected mice with C. cladosporioides spore suspension and conducted several assays on the lungs. Pulmonary hemorrhage symptoms and congestion were most severe on days 1, 2, and 3 post-inoculation (PI). Extensive inflammatory cell infiltration occurred throughout the period of infection. More spores and hyphae colonizing the lungs were detected on days 1, 2, and 3 PI, and fewer spores and hyphae were observed within 21 d of infection. Numerous macrophages, dendritic cells, and neutrophils were observed on day 5 PI, along with upregulation of CD54, an intercellular adhesion molecule. Th1 and Th2 cells increased after infection; specifically, Th2 cells increased considerably on day 5 PI. These results suggest that days 2 and 5 PI represent the inflammatory peak in the lungs and that the Th2 and Th1 signaling pathways are potentially involved in pulmonary immune responses. In conclusion, the further adaptive immune responses played important roles in establishing effective pulmonary immunity against C. cladosporioides systemic infections based on innate immune responses.

Association between exercise-induced pulmonary hemorrhage and performance in Thoroughbred racehorses

2005 ◽  
Vol 227 (5) ◽  
pp. 768-774 ◽  
Author(s):  
Kenneth W. Hinchcliff ◽  
Melissa A. Jackson ◽  
Paul S. Morley ◽  
James A. Brown ◽  
Anthony F. Dredge ◽  
...  
Keyword(s):  
Pulmonary Hemorrhage ◽  
Thoroughbred Racehorses ◽  
And Performance ◽  
Exercise Induced

Fat embolism syndrome with pulmonary hemorrhage of unknown origin

2000 ◽  
Vol 48 (3) ◽  
pp. 383
Author(s):  
Hae Chul Jung ◽  
Ki Hwan Jung ◽  
Byung Gyu Kim ◽  
Kyung Kyu Kim ◽  
Sang Youb Lee ◽  
...  
Keyword(s):  
Pulmonary Hemorrhage ◽  
Unknown Origin ◽  
Fat Embolism ◽  
Fat Embolism Syndrome ◽  
Embolism Syndrome

A Novel Immunoablative Regimen Utilized In The Successful Remission Of Pulmonary Hemorrhage In An Adolescent Female With Systemic Lupus Erythematosus

2014 ◽  
Vol 133 (2) ◽  
pp. AB185
Author(s):  
Vivian E. Cino ◽  
Alexander Constantinescu ◽  
Kristina Deeter ◽  
Faina Shenderov ◽  
Joan Spiro ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Pulmonary Hemorrhage ◽  
Adolescent Female ◽  
Systemic Lupus

scholarly journals Pulmonary hemorrhage after intracoronary stent placement

1994 ◽  
Vol 24 (1) ◽  
pp. 91-94 ◽  
Author(s):  
David L. Brown ◽  
Andrew I. MacIsaac ◽  
Eric J. Topol
Keyword(s):  
Stent Placement ◽  
Pulmonary Hemorrhage

scholarly journals Pulmonary hemorrhage as a manifestation of systemic lupus erythematosus

2004 ◽  
Vol 59 (1) ◽  
pp. 47-50 ◽  
Author(s):  
Bruno Hollanda Santos ◽  
Rodrigo Ribeiro Santos ◽  
Celeide Fátima Santos ◽  
Adriana Maria Kakehasi ◽  
Hermann Alexandre Vivacqua Von Tiesenhausen
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Connective Tissue ◽  
Lupus Erythematosus ◽  
Pulmonary Hemorrhage ◽  
Pulse Therapy ◽  
Loss Of Consciousness ◽  
Systemic Lupus ◽  
Sudden Loss ◽  
American College Of Rheumatology ◽  
High Level

The authors report a case of a 19-year-old woman admitted for the investigation of fever and hemolytic anemia for the previous 2 months. As an inpatient, she had convulsions and sudden loss of consciousness, developing hemoptysis, hypoxia, and respiratory insufficiency. Examination showed pericardial effusions on the echocardiogram and bilateral alveolar condensations on the thoracic radiograph. A hypothetical diagnosis of systemic lupus erythematosus was made, and measurement of the antinuclear factor was requested along with daily pulse therapy methylprednisolone, in spite of which the outcome was fatal. Afterwards, the result of the antinuclear factor test was positive, with a titer of 1:5120, showing a fine punctiform pattern, fulfilling the criteria for systemic lupus erythematosus according to the American College of Rheumatology. Secondary pulmonary hemorrhage in this connective tissue disease is an uncommon but serious complication that involves a high level of mortality in spite of intensive treatment, as is also reported in the literature.

PULMONARY HEMORRHAGE IN SYSTEMIC LUPUS ERYTHEMATOSUS

Medicine ◽  
1978 ◽  
Vol 57 (6) ◽  
pp. 545 ◽  
Author(s):  
JEREMIAH W. EAGEN ◽  
VINCENT A. MEMOLI ◽  
JIMMY L. ROBERTS ◽  
GUY R. MATTHEW ◽  
MELVIN M. SCHWARTZ ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Pulmonary Hemorrhage ◽  
Systemic Lupus
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