Serum Levels of Guanidino Compounds in Acute Renal Failure

Guanidines 2 ◽  
1989 ◽  
pp. 261-265
Author(s):  
Yasushi Suzuki ◽  
Fumitake Gejyo ◽  
Masaaki Arakawa
Guanidines ◽  
1985 ◽  
pp. 287-294 ◽  
Author(s):  
Yoshinori Kōsogabe ◽  
Yōji Ochiai ◽  
Rikiya Matsuda ◽  
Kyoko Nishitani ◽  
Shinya Abe ◽  
...  

Author(s):  
Reinaldo Martinelli ◽  
Cácia M. Matos ◽  
Heonir Rocha

To study the frequency and examine the role of rhabdomyolysis in the acute renalfailure in tetanus 18 patients with the diagnosis of generalized tetanus consecutively admitted to the infectious disease hospital were evaluated. Ofthese 14 were male and 4female with mean age of 31.8± 2.0 years. Except for mild proteinuria recorded in 9 patients, the urinalysis were unremarkable. Serum creatinine higher than 1.4mg/dl was recorded in 39% of the patients, abnormal levels of CPK in 87,5% and serum myoglobin greater than 120µg/l in 39% of the patients. Oliguria was documented in one patient and none required diafysis therapy. No correlation wasfound between renal failure and myoglobin and/or CPK serum levels. Acute renalfailure in tetanus was not infrequent; usualfy it was non-oliguric, mild and transient and not related to the severity of the disease or to serum levels of myoglobin and/or CPK.


Guanidines ◽  
1985 ◽  
pp. 317-325 ◽  
Author(s):  
Yōji Ochiai ◽  
Rikiya Matsuda ◽  
Kyōko Nishitani ◽  
Yoshinori Kōsogabe ◽  
Shinya Abe ◽  
...  

2016 ◽  
Vol 4 (3) ◽  
pp. 329-336 ◽  
Author(s):  
Ahmed Atwa ◽  
Rehab Hegazy ◽  
Nermeen Shaffie ◽  
Neamat Yassin ◽  
Sanaa Kenawy

BACKGROUND: Rhabdomyolysis (RM)-induced acute renal failure (ARF) accounts for about 10–40% of all cases of ARF.AIM: The present study investigated the possible protective effect of two nitric oxides (NO)-releasing third generation β-blockers, carvedilol (Carv) and nebivolol (Nebi), against RM-mimicking glycerol (Gly)-induced ARF in rats.MATERIAL AND METHODS: After 24 h dehydration, rats received a single dose of 50% Gly (8 ml/kg, im). They were treated with vehicle, Carv (2.5 mg/kg/day, po) or Nebi (10 mg/kg, po) for 3 successive days starting from an hour prior to Gly injection. Evaluation of blood pressure and locomotor activity was performed during the experiment. 72 h following Gly administration, total protein in the urine, serum levels of creatinine, blood urea nitrogen, sodium and potassium as well as the renal contents of malondialdehyde, reduced glutathione and NO were assessed, together with a histopathological examination of renal tissues.RESULTS: Carv and Nebi attenuated Gly-induced renal dysfunction and histopathological alterations. They decreased the Gly-induced oxidative stress and increased renal NO concentration. Restoration of normal blood pressure and improvement of locomotor activity were also observed.CONCLUSION: The results clearly demonstrate protective effects of Carv and Nebi against renal damage involved in RM-induced ARF and suggest a role of their antioxidant and NO-releasing properties.


2019 ◽  
Vol 7 (1) ◽  
pp. 804-813
Author(s):  
Ralda Christina Ursula Pelealu ◽  
Untung Sudharmono

Acute renal failure is a set of clinical symptoms characterized by increased levels of creatinine and blood urea nitrogen and a rapids decrease in the rate of glomerular filtration. The Objectives of this study was to determine the effectiveness of brewed tin water (Ficus Carica L) against ureum and creatinine serum of male Wistar strain rats in acute renal Failur. The subject of the research were 30 male rats weighing 180-200 grams and 2-3 months old, which were divided into 3 groups, namely the negative control group, the positive control group and the treatment group. Each group consisted of 10 rats. The negative control group was only given food and drink as usual. The positive control group and the treatment group were induced with gentamicin 12 mg / intraperitonial for 7 days to increase ureum and creatinine serum levels. The treatment group was given steeping treatment of 0.65 grams of boiled figs leaf in 100cc of given 3.6cc/orally for 7 days. One way ANOVA test was conducted to analyze the study using SPSS version 24. The results found there are no significant differences in ureum serum levels between the treatment group and negative control group (p = 0.252) but there were significant differences in the ureum serum value between the treatment group and positive control group (p <0.05). There was a significant difference in the value of creatinine serum between the treatment group, the positive control group and the negative control group (p <0.05). As Conclusions boiled figs leaf (Ficus Carica L) has an effect on decreasing ureum and creatinine serum levels in male wistar rats with acute renal failure..


Author(s):  
Gaikwad S. B ◽  
Agte A. B. ◽  
Niturkar G. S.

Measurement of the concentration of electrolytes in serum levels of sodium, potassium, calcium, magnesium and chloride is important in acute renal failure (ARF). The level of these electrolytes in serum was analyzed in predialysis and post dialysis. The data obtained revealed that decrease in serum level of sodium, potassium, magnesium and chloride while increase in serum level of calcium was seen in post dialysis as compared to predialysis.


2020 ◽  
Vol 50 (5) ◽  
Author(s):  
Paula Reis Ribeiro ◽  
Matheus Viezzer Bianchi ◽  
Luan Cleber Henker ◽  
Fernando Gonzales ◽  
Saulo Petinatti Pavarini

ABSTRACT: Bee envenomation is frequent in humans and dogs, but uncommon in horses. This study aimed to describe a case of acute renal failure following mass envenomation in a horse. A mare was attacked by a swarm of bees and showed reluctance to move, epistaxis, and dark-brown urine. Biochemical exams revealed increase in urea and creatine serum levels. The mare did not respond to treatment and euthanasia was elected after four days of clinical course. At the necropsy, there were multifocal pinpoint to elevated skin lesions associated with edema and hemorrhage, which extended to the subcutaneous tissue and skeletal muscle, and the kidneys were diffusely dark-brown and friable. Microscopically, renal tubules were distended and filled with an orange-red, hyaline globular material, and had severe epithelial tubular cell necrosis. The diagnosis was established based on clinical and histological analysis, and pathological evaluation was essential to confirm acute renal failure due to bee sting toxicity.


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