Growth Factor Production by Mammary Tumor Cells

1987 ◽  
pp. 239-252 ◽  
Author(s):  
William R. Kidwell ◽  
S. Mohanam ◽  
David S. Salomon
Keyword(s):  
Growth Factor ◽  
Tumor Cells ◽  
Mammary Tumor ◽  
Mammary Tumor Cells ◽  
Factor Production ◽  
Growth Factor Production

scholarly journals BSCI-11. STROMAL PLATELET DERIVED GROWTH FACTOR RECEPTOR-β (PDGFRβ) PROMOTES BREAST CANCER BRAIN METASTASIS

2019 ◽  
Vol 1 (Supplement_1) ◽  
pp. i3-i3
Author(s):  
Katie Thies ◽  
Anisha Hammer ◽  
Blake Hildreth ◽  
Luke Russell ◽  
Steven Sizemore ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Brain Metastasis ◽  
Brain Metastases ◽  
Tumor Cells ◽  
Mammary Tumor ◽  
Growth Factor Receptor ◽  
Platelet Derived Growth Factor ◽  
Mammary Tumor Cells ◽  
The Brain

Abstract Stromal platelet-derived growth factor receptor-beta (PDGFRβ) has emerged as an actionable mediator of breast tumor-stromal communication. As a receptor tyrosine kinase, PDGFRβ is activated by its ligand, PDGFB, which is released by neighboring tumor epithelium and endothelium. However, how PDGF signaling mediates breast cancer (BC) initiation, progression, and metastasis remains unclear. To evaluate PDGFRβ in this disease, we developed a mouse model of stromal-specific PDGFRβ activation using the Fsp-cre transgene previously published by our group. Mesenchymal-specific activation of PDGFRβ promotes preferential experimental brain metastasis of PDGFB-expressing mammary tumor cells when injected intravenously and accelerates intracranial tumor growth of these cells. Mammary tumor cells expressing low levels of PDGFB do not exhibit a similar increase in brain metastases in PDGFRβ mutant mice. To our knowledge, this is the first example where genetic manipulation of the stroma leads to an increased incidence of BCBM. Our pre-clinical data suggests that primary breast tumors that express high PDGFB could preferentially metastasize to the brain. To test this in patients, we analyzed PDGFB protein expression in a tissue microarray comprised of HER2-positive and triple negative BC primary tumors. While high PDGFB did not correlate with site-independent metastatic recurrence, it was prognostic of brain metastasis, mirroring our mouse data. Our findings suggest that high primary tumor PDGFB expression defines a subset of BC patients predisposed to brain metastases. These patients may benefit from therapeutic intervention of PDGFRβ signaling. To test this pre-clinically, we treated mice harboring intracranial tumors with the PDGFR-specific inhibitor, crenolanib. Excitingly, crenolanib treatment significantly inhibited the brain tumor burden in these mice. Combined, our findings (1) advocate that primary tumor expression of PDGFB is a novel prognostic biomarker for the development of BCBM and (2) support clinical trial evaluation of PDGFR inhibitors for the prevention and treatment of BCBM.

Characterization of a sheep pituitary-derived growth factor for rat and human mammary tumor cells

1984 ◽  
Vol 25 (4) ◽  
pp. 213-229 ◽  
Author(s):  
Tatsuhiko Ikeda ◽  
David Danielpour ◽  
David A. Sirbasku
Keyword(s):  
Growth Factor ◽  
Tumor Cells ◽  
Mammary Tumor ◽  
Mammary Tumor Cells ◽  
Human Mammary Tumor Cells

scholarly journals Activation of ErbB-2 via a hierarchical interaction between ErbB-2 and type I insulin-like growth factor receptor in mammary tumor cells

Oncogene ◽  
2001 ◽  
Vol 20 (1) ◽  
pp. 34-47 ◽  
Author(s):  
Maria Eugenia Balañá ◽  
Leticia Labriola ◽  
Mariana Salatino ◽  
Federico Movsichoff ◽  
Giselle Peters ◽  
...  
Keyword(s):  
Growth Factor ◽  
Tumor Cells ◽  
Mammary Tumor ◽  
Growth Factor Receptor ◽  
Type I ◽  
Insulin Like Growth Factor ◽  
Mammary Tumor Cells ◽  
Hierarchical Interaction

Androgen and fibroblast growth factor (FGF) regulation of FGF receptors in S115 mouse mammary tumor cells.

Endocrinology ◽  
1995 ◽  
Vol 136 (5) ◽  
pp. 2179-2188 ◽  
Author(s):  
J K Ruohola ◽  
E M Valve ◽  
S Vainikka ◽  
K Alitalo ◽  
P L Härkönen
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Tumor Cells ◽  
Mammary Tumor ◽  
Fibroblast Growth ◽  
Mammary Tumor Cells ◽  
Mouse Mammary Tumor ◽  
Mouse Mammary Tumor Cells

Protein kinase C is differentially regulated by thrombin, insulin, and epidermal growth factor in human mammary tumor cells

1988 ◽  
Vol 175 (1) ◽  
pp. 74-80 ◽  
Author(s):  
Maria Laura Gomez ◽  
Estela E. Medrano ◽  
Eduardo G.A. Cafferatta ◽  
Maria Teresa Tellez-In̄on
Keyword(s):  
Protein Kinase C ◽  
Growth Factor ◽  
Protein Kinase ◽  
Epidermal Growth Factor ◽  
Tumor Cells ◽  
Mammary Tumor ◽  
Mammary Tumor Cells ◽  
Kinase C ◽  
Epidermal Growth ◽  
Human Mammary Tumor Cells
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