Porcine Cytomegalovirus (PCMV)

1989 ◽  
pp. 326-333 ◽  
Author(s):  
V. Ohlinger
Keyword(s):  
Porcine Cytomegalovirus

scholarly journals Cytomegalovirus infection in a pig in South Africa

2002 ◽  
Vol 73 (1) ◽  
Author(s):  
M.G. Collett ◽  
D.C. Roberts
Keyword(s):  
South Africa ◽  
Inclusion Bodies ◽  
Cytomegalovirus Infection ◽  
Mouth Breathing ◽  
Nasal Discharge ◽  
Intranuclear Inclusion ◽  
Porcine Cytomegalovirus ◽  
Histological Evidence

An 8-week-old piglet with dyspnoea, bilateral mucopurulent nasal discharge and mouth breathing was euthanased and a necropsy was performed. Apart from histological evidence of diffuse rhinitis, large intranuclear inclusion bodies, pathognomonic for porcine cytomegalovirus infection, were detected within mucous glands on the nasal turbinates. This is the first such case to be diagnosed in South Africa.

scholarly journals Antibody Cross-Reactivity between Porcine Cytomegalovirus (PCMV) and Human Herpesvirus-6 (HHV-6)

Viruses ◽  
2017 ◽  
Vol 9 (11) ◽  
pp. 317 ◽  
Author(s):  
Uwe Fiebig ◽  
Angela Holzer ◽  
Daniel Ivanusic ◽  
Elena Plotzki ◽  
Hartmut Hengel ◽  
...  
Keyword(s):  
Human Herpesvirus ◽  
Cross Reactivity ◽  
Human Herpesvirus 6 ◽  
Porcine Cytomegalovirus ◽  
Herpesvirus 6

Superinfection with porcine cytomegalovirus initiating transplacental infection

1988 ◽  
Vol 16 (2) ◽  
pp. 189-193 ◽  
Author(s):  
N. Edington ◽  
S. Broad ◽  
A.E. Wrathall ◽  
J.T. Done
Keyword(s):  
Porcine Cytomegalovirus ◽  
Transplacental Infection

scholarly journals Comparative Analysis of Roseoloviruses in Humans, Pigs, Mice, and Other Species

Viruses ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 1108 ◽  
Author(s):  
Joachim Denner ◽  
Tarin M. Bigley ◽  
Tuan L. Phan ◽  
Cosima Zimmermann ◽  
Xiaofeng Zhou ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Immune Responses ◽  
Neurological Diseases ◽  
Human Herpesvirus ◽  
Febrile Seizures ◽  
Porcine Cytomegalovirus ◽  
Cellular Immune Responses ◽  
High Prevalence ◽  
Disease Associations ◽  
Cellular Immune

Viruses of the genus Roseolovirus belong to the subfamily Betaherpesvirinae, family Herpesviridae. Roseoloviruses have been studied in humans, mice and pigs, but they are likely also present in other species. This is the first comparative analysis of roseoloviruses in humans and animals. The human roseoloviruses human herpesvirus 6A (HHV-6A), 6B (HHV-6B), and 7 (HHV-7) are relatively well characterized. In contrast, little is known about the murine roseolovirus (MRV), also known as murine thymic virus (MTV) or murine thymic lymphotrophic virus (MTLV), and the porcine roseolovirus (PRV), initially incorrectly named porcine cytomegalovirus (PCMV). Human roseoloviruses have gained attention because they can cause severe diseases including encephalitis in immunocompromised transplant and AIDS patients and febrile seizures in infants. They have been linked to a number of neurological diseases in the immunocompetent including multiple sclerosis (MS) and Alzheimer’s. However, to prove the causality in the latter disease associations is challenging due to the high prevalence of these viruses in the human population. PCMV/PRV has attracted attention because it may be transmitted and pose a risk in xenotransplantation, e.g., the transplantation of pig organs into humans. Most importantly, all roseoloviruses are immunosuppressive, the humoral and cellular immune responses against these viruses are not well studied and vaccines as well as effective antivirals are not available.

scholarly journals Impact of porcine cytomegalovirus on long-term orthotopic cardiac xenotransplant survival

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Joachim Denner ◽  
Matthias Längin ◽  
Bruno Reichart ◽  
Luise Krüger ◽  
Uwe Fiebig ◽  
...  
Keyword(s):  
Immunosuppressive Regimen ◽  
Complete Loss ◽  
Orthotopic Heart Transplantation ◽  
Survival Times ◽  
Post Transplantation ◽  
Porcine Cytomegalovirus ◽  
And Control ◽  
First Time ◽  
Pai 1

Abstract Xenotransplantation using pig organs has achieved survival times up to 195 days in pig orthotopic heart transplantation into baboons. Here we demonstrate that in addition to an improved immunosuppressive regimen, non-ischaemic preservation with continuous perfusion and control of post-transplantation growth of the transplant, prevention of transmission of the porcine cytomegalovirus (PCMV) plays an important role in achieving long survival times. For the first time we demonstrate that PCMV transmission in orthotopic pig heart xenotransplantation was associated with a reduced survival time of the transplant and increased levels of IL-6 and TNFα were found in the transplanted baboon. Furthermore, high levels of tPA-PAI-1 complexes were found, suggesting a complete loss of the pro-fibrinolytic properties of the endothelial cells. These data show that PCMV has an important impact on transplant survival and call for elimination of PCMV from donor pigs.

scholarly journals Genomic organization and molecular characterization of porcine cytomegalovirus

Virology ◽  
2014 ◽  
Vol 460-461 ◽  
pp. 165-172 ◽  
Author(s):  
Weiwei Gu ◽  
Nanfang Zeng ◽  
Lei Zhou ◽  
Xinna Ge ◽  
Xin Guo ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Genomic Organization ◽  
Porcine Cytomegalovirus

scholarly journals Objective pathogen monitoring in nursery and finisher pigs by monthly laboratory diagnostic testing

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Nicole B. Goecke ◽  
Maja Kobberø ◽  
Thomas K. Kusk ◽  
Charlotte K. Hjulsager ◽  
Ken Steen Pedersen ◽  
...  
Keyword(s):  
Real Time ◽  
San Francisco ◽  
Influenza A Virus ◽  
High Throughput ◽  
Real Time Pcr ◽  
Influenza A ◽  
Clinical Signs ◽  
Swine Influenza ◽  
Porcine Cytomegalovirus ◽  
Swine Influenza A Virus

Abstract Background Infectious diseases are of great economic importance in commercial pig production, causing both clinical and subclinical disease, with influence on welfare, productivity, and antibiotic use. The causes of these diseases are often multifactorial and laboratory diagnostics are seldom routinely performed. The aim of the present study was to explore the benefits of monthly pathogen monitoring in nursery and finisher herds and to examine association between laboratory results and observed clinical signs, including coughing and diarrhoea. Three monthly samplings were conducted in three different age groups in six nursery and four finisher production units. For each unit, two pens were randomly selected in each age group and evaluated for coughing and diarrhoea events. Furthermore, faecal sock and oral fluid samples were collected in the selected pens and analysed for 18 respiratory and enteric viral and bacterial pathogens using the high-throughput real-time PCR BioMark HD platform (Fluidigm, South San Francisco, USA). Results In total, 174 pens were sampled in which eight coughing events and 77 diarrhoeic events were observed. The overall findings showed that swine influenza A virus, porcine circovirus 2, porcine cytomegalovirus, Brachyspira pilosicoli, Lawsonia intracellularis, Escherichia coli fimbria types F4 and F18 were found to be prevalent in several of the herds. Association between coughing events and the presence of swine influenza A virus, porcine cytomegalovirus (Cq ≤ 20) or a combination of these were found. Furthermore, an association between diarrhoeic events and the presence of L. intracellularis (Cq ≤ 24) or B. pilosicoli (Cq ≤ 26) was found. Conclusions The use of high-throughput real-time PCR analysis for continuous monitoring of pathogens and thereby dynamics of infections in a pig herd, provided the veterinarian and farmer with an objective knowledge on the distribution of pathogens in the herd. In addition, the use of a high-throughput method in combination with information about clinical signs, productivity, health status and antibiotic consumption, presents a new and innovative way of diagnosing and monitoring pig herds and even to a lower cost than the traditional method.

Epizootic infection of a swiss swine herd with porcine cytomegalovirus

2015 ◽  
Vol 152 (1) ◽  
pp. 42 ◽  
Author(s):  
H. Marti ◽  
A. Stahel ◽  
K. Hoffmann ◽  
K. Wäsle ◽  
M. Engels ◽  
...  
Keyword(s):  
Swine Herd ◽  
Porcine Cytomegalovirus

Seroprevalence of porcine cytomegalovirus and sapovirus infection in pigs in Hunan province, China

2011 ◽  
Vol 157 (3) ◽  
pp. 521-524 ◽  
Author(s):  
Guo-Hua Liu ◽  
Run-Cheng Li ◽  
Jing Li ◽  
Ze-Bin Huang ◽  
Chao-Ting Xiao ◽  
...  
Keyword(s):  
Hunan Province ◽  
Porcine Cytomegalovirus

scholarly journals The behaviour of porcine cytomegalovirus in commercial pig herds

1976 ◽  
Vol 76 (1) ◽  
pp. 125-135 ◽  
Author(s):  
W. Plowright ◽  
N. Edington ◽  
R. G. Watt
Keyword(s):  
Virus Infection ◽  
Antibody Response ◽  
Respiratory Disease ◽  
Indirect Immunofluorescence ◽  
Cytomegalovirus Infection ◽  
High Titre ◽  
Atrophic Rhinitis ◽  
Serological Study ◽  
Porcine Cytomegalovirus ◽  
Virus Excretion

SUMMARYA longitudinal, virological and serological study of pigs in two herds with respiratory disease showed that infection by porcine cytomegalovirus (PCMV) was universal in both.Virus excretion usually began when piglets were between 3 and 6 weeks of age and reached a maximum between 5 and 8 weeks; it was usually no longer detectable at 11–12 weeks. Antibody demonstrable in indirect immunofluorescence (IIF) tests was present to moderate or high titre in all piglets at 2–3 weeks. This was presumed to be maternal in origin as it declined in titre between 2–3 and 5–6 weeks. After this fall the majority of piglets showed seroconversion as a result of virus infection. One group of 12 pigs in which infection occurred earlier than usual showed a very poor antibody response, which, nevertheless, persisted through to week 27.The findings are discussed with relation to porcine atrophic rhinitis and cytomegalovirus infection in other species.

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