Phenotypic modification of human glioma

1986 ◽  
pp. 35-41 ◽  
Author(s):  
R. I. Freshney ◽  
Margaret C. Frame ◽  
P. F. T. Vaughan ◽  
D. I. Graham
Keyword(s):  
Human Glioma

Mutant IκBα Suppresses Hypoxia-Induced VEGF Expression Through Downregulation of HIF-1α and COX-2 in Human Glioma Cells

2005 ◽  
Vol 15 (3) ◽  
pp. 139-149 ◽  
Author(s):  
Yoshihira Kimba ◽  
Tatsuya Abe ◽  
Jian Liang Wu ◽  
Ryo Inoue ◽  
Minoru Fukiki ◽  
...  
Keyword(s):  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Vegf Expression ◽  
Cox 2

Down Regulated Expression of Claudin-1 and Claudin-5 and Up Regulation of β-Catenin: Association with Human Glioma Progression

2014 ◽  
Vol 13 (8) ◽  
pp. 1413-1426 ◽  
Author(s):  
Hanuma Karnati ◽  
Manas Panigrahi ◽  
Noor Shaik ◽  
Nigel Greig ◽  
S. Bagadi ◽  
...  
Keyword(s):  
Human Glioma ◽  
Regulated Expression ◽  
Glioma Progression

scholarly journals Differential expression and role of p21cip/waf1 and p27kip1 in TNF-α-induced inhibition of proliferation in human glioma cells

2007 ◽  
Vol 6 (1) ◽  
pp. 42 ◽  
Author(s):  
Pabbisetty Kumar ◽  
Anjali Shiras ◽  
Gowry Das ◽  
Jayashree C Jagtap ◽  
Vandna Prasad ◽  
...  
Keyword(s):  
Differential Expression ◽  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Inhibition Of Proliferation ◽  
Tnf Α

scholarly journals Assessment of multiparametric MRI in a human glioma model to monitor cytotoxic and anti-angiogenic drug effects

2010 ◽  
Vol 24 (5) ◽  
pp. 473-482 ◽  
Author(s):  
Benjamin Lemasson ◽  
Thomas Christen ◽  
Xavier Tizon ◽  
Régine Farion ◽  
Nadège Fondraz ◽  
...  
Keyword(s):  
Drug Effects ◽  
Multiparametric Mri ◽  
Human Glioma ◽  
Glioma Model

scholarly journals Correction to: Akt/FoxM1 signaling pathway-mediated upregulation of MYBL2 promotes progression of human glioma

2021 ◽  
Vol 40 (1) ◽  
Author(s):  
Xue Zhang ◽  
Qiao-Li LV ◽  
Yuan-Tao Huang ◽  
Li-Hua Zhang ◽  
Hong-Hao Zhou
Keyword(s):  
Signaling Pathway ◽  
Human Glioma

scholarly journals Indirubin exerts anticancer effects on human glioma cells by inducing apoptosis and autophagy

AMB Express ◽  
2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Zhaohui Li ◽  
Han Wang ◽  
Jun Wei ◽  
Liang Han ◽  
Zhigang Guo
Keyword(s):  
Apoptotic Cell ◽  
Treatment Strategies ◽  
Glioma Cells ◽  
Annexin V ◽  
Metastatic Potential ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Efficient Treatment ◽  
Cell Percentage ◽  
Anticancer Effects

Abstract Glioma causes significant mortality across the world and the most aggressive type of brain cancer. The incidence of glioma is believed to increase in the next few decades and hence more efficient treatment strategies need to be developed for management of glioma. Herein, we examined the anticancer effects of Indirubin against a panel of human glioma cells and attempted to explore the underlying mechanisms. The results of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay showed that Indirubin could inhibit the growth of all the glioma cells but the lowest IC50 of 12.5 µM was observed against the U87 and U118 glioma cells. Additionally, the cytotoxic effects of Indirubin were comparatively negligible against the normal astrocytes with an IC50 of > 100 µM. Investigation of mechanism of action, revealed that Indirubin exerts growth inhibitory effects on the U87 and U118 glioma cells by autophagic and apoptotic cell death. Annexin V/PI staining assay showed that apoptotic cell percentage increased dose dependently. Apoptosis was associated with increase in Bax decrease in Bcl-2 expressions. Additionally, the expression of autophagic proteins such as LC3II, ATG12, ATG15 and Beclin 1 was also increased. Wound heal assay showed that Indirubin caused remarkable decrease in the migration of the U87 and U118 cells indicative of anti-metastatic potential of Indirubin. Taken together, these results suggest that Indirubin exerts potent anticancer effects on glioma cells and may prove essential in the management of glioma.

Sign in / Sign up

Export Citation Format

Share Document