Prevention of Sudden Death: Selection of Patients at Risk

1983 ◽  
pp. 89-97
Author(s):  
Jeffrey S. Borer ◽  
David Miller ◽  
Paul Phillips ◽  
Jeffrey W. Moses ◽  
Harvey Goldberg ◽  
...  
Keyword(s):  
At Risk ◽  
Sudden Death ◽  
Patients At Risk ◽  
Selection Of Patients ◽  
Selection Of

scholarly journals ALGORITHMS FOR SOLVING PROBLEMS OF PRE-TRANSFUSION IMMUNOHEMATOLOGICAL TESTING

2019 ◽  
Vol 64 (2) ◽  
pp. 222-233
Author(s):  
I. A. Pashkova
Keyword(s):  
At Risk ◽  
Blood Transfusion ◽  
Individual Selection ◽  
Donor Blood ◽  
Effective System ◽  
Patients At Risk ◽  
Screening And Identification ◽  
Transfusion Complications ◽  
Transfusion Reactions ◽  
Selection Of

Introduction. Screening and identification of anti-erythrocyte alloimmune antibodies in recipients is an important and necessary step in their testing before blood transfusion.Aim. To formulate algorithms that could facilitate the process of pre-transfusion immunohematological testing.General findings. Such a testing allows the development of post-transfusion reactions and complications to be avoided. The presence of alloantibodies of various specificities and autoantibodies in the test blood may complicate pre-transfusion testing and require the use of additional methods (adsorption, elution, etc.). The author has proposed an effective system of algorithms for conducting immunohematological studies, which can be used to identify patients at risk of developing immune post-transfusion complications and ensure an individual selection of compatible donor blood-transfusion products.

scholarly journals Immunotherapy for Early Stage Colorectal Cancer: A Glance into the Future

Cancers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1990
Author(s):  
Romain Cohen ◽  
Qian Shi ◽  
Thierry André
Keyword(s):  
Colorectal Cancer ◽  
Checkpoint Inhibitors ◽  
Early Stage ◽  
Disease Recurrence ◽  
Prognostic Features ◽  
T Cell Infiltration ◽  
Tumor Mutational Burden ◽  
Patients At Risk ◽  
Selection Of Patients ◽  
Selection Of

Immune checkpoint inhibitors (ICI) have reshaped therapeutic strategies for cancer patients. The development of ICI for early stage colorectal cancer is accompanied by specific challenges: (i) the selection of patients who are likely to benefit from these treatments, i.e., patients with tumors harboring predictive factors of efficacy of ICI, such as microsatellite instability and/or mismatch repair deficiency (MSI/dMMR), or other potential parameters (increased T cell infiltration using Immunoscore® or others, high tumor mutational burden, POLE mutation), (ii) the selection of patients at risk of disease recurrence (poor prognostic features), and (iii) the choice of an accurate clinical trial methodological framework. In this review, we will discuss the ins and outs of clinical research of ICI for early stage MSI/dMMR CC patients in adjuvant and neoadjuvant settings. We will then summarize data that might support the development of ICI in localized colorectal cancer beyond MSI/dMMR.

scholarly journals P6417Extended wearable cardioverter defibrillator use in patients at-risk for sudden death

2017 ◽  
Vol 38 (suppl_1) ◽  
Author(s):  
V. Kutyifa ◽  
K. Vermilye ◽  
U. Daimee ◽  
S. McNitt ◽  
H. Klein ◽  
...  
Keyword(s):  
At Risk ◽  
Sudden Death ◽  
Cardioverter Defibrillator ◽  
Wearable Cardioverter Defibrillator ◽  
Patients At Risk
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