The genomic structure of two protein kinase CK2α genes of Xenopus laevis and features of the putative promoter region

2001 ◽  
pp. 175-183
Author(s):  
Vivian Wilhelm ◽  
Guy Neckelman ◽  
Jorge E. Allende ◽  
Catherine C. Allende
Keyword(s):  
Protein Kinase ◽  
Xenopus Laevis ◽  
Promoter Region ◽  
Genomic Structure ◽  
Putative Promoter ◽  
Putative Promoter Region

DNA methylation at the putative promoter region of the human dopamine D2 receptor gene

Neuroreport ◽  
1999 ◽  
Vol 10 (6) ◽  
pp. 1249-1255 ◽  
Author(s):  
Violeta Popendikyte ◽  
Arvydas Laurinavicius ◽  
Andrew D. Paterson ◽  
Fabio Macciardi ◽  
James L. Kennedy ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Promoter Region ◽  
Dopamine D2 Receptor ◽  
Receptor Gene ◽  
D2 Receptor ◽  
Putative Promoter ◽  
Putative Promoter Region ◽  
Dopamine D2

Structural analysis of the 5′ region of mouse and human huntington disease genes reveals conservation of putative promoter region and di- and trinucleotide polymorphisms

Genomics ◽  
1995 ◽  
Vol 25 (3) ◽  
pp. 707-715 ◽  
Author(s):  
Biaoyang Lin ◽  
Jamal Nasir ◽  
Michael A. Kalchman ◽  
Helen Mcdonald ◽  
Jutta Zeisler ◽  
...  
Keyword(s):  
Structural Analysis ◽  
Huntington Disease ◽  
Promoter Region ◽  
Disease Genes ◽  
Putative Promoter ◽  
Putative Promoter Region

scholarly journals Genetic Variants of Wnt Transcription Factor TCF-4 (TCF7L2) Putative Promoter Region Are Associated with Small Intestinal Crohn's Disease

PLoS ONE ◽  
2009 ◽  
Vol 4 (2) ◽  
pp. e4496 ◽  
Author(s):  
Maureen J. Koslowski ◽  
Irmgard Kübler ◽  
Mathias Chamaillard ◽  
Elke Schaeffeler ◽  
Walter Reinisch ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Genetic Variants ◽  
Promoter Region ◽  
Putative Promoter ◽  
Putative Promoter Region ◽  
Small Intestinal

Lactoferrin gene promoter: structural integrity and nonexpression in HL60 cells

Blood ◽  
1992 ◽  
Vol 79 (11) ◽  
pp. 2998-3006 ◽  
Author(s):  
JJ Johnston ◽  
P Rintels ◽  
J Chung ◽  
J Sather ◽  
EJ Jr Benz ◽  
...  
Keyword(s):  
Gene Expression ◽  
Promoter Region ◽  
Primer Extension ◽  
Myelogenous Leukemia ◽  
Northern Analysis ◽  
Human Neutrophils ◽  
Putative Promoter ◽  
Putative Promoter Region ◽  
Hl60 Cells ◽  
Lactoferrin Gene

Lactoferrin is a member of the transferrin family of iron-binding proteins. It is found in several glandular epithelial tissues and human neutrophils, where it is localized to secondary granules. To examine the mechanisms controlling lactoferrin gene expression in neutrophils and defects in its expression in acute leukemia, we have cloned a lactoferrin cDNA from a chronic myelogenous leukemia library, and used it to obtain genomic clones representing the chromosomal lactoferrin gene. Using polymerase chain reaction, primer extension, and S1 analysis, we have identified the 5′ end of the lactoferrin mRNA. We have defined a putative promoter region for the gene, and characterized its first two exons. In addition, we have examined the structure of these regions in DNA from HL60 cells. HL60 is a leukemic cell line that undergoes phenotypic neutrophil maturation on exposure to dimethyl sulfoxide (DMSO). However, the cells cannot be induced to express any secondary granule protein genes. We have shown that the 5′ end of the lactoferrin gene, including the putative promoter region, is entirely normal in HL60. By Northern analysis, nuclear run-on studies, and primer extension assays we have shown that the gene is not transcribed in DMSO-induced HL60 cells. This supports the hypothesis that the defect in HL60 is an abnormality in the production or activity of a transacting regulator of lactoferrin gene expression.

Cloning and determination of a putative promoter region of a mouse ribosomal deoxyribonucleic acid fragment

Biochemistry ◽  
1980 ◽  
Vol 19 (16) ◽  
pp. 3780-3786 ◽  
Author(s):  
Yukio Mishima ◽  
Ryo Kominami ◽  
Tasuku Honjo ◽  
Masami Muramatsu
Keyword(s):  
Promoter Region ◽  
Deoxyribonucleic Acid ◽  
Putative Promoter ◽  
Putative Promoter Region ◽  
Acid Fragment

ANALYSIS OF THE PUTATIVE PROMOTER REGION OF THE GIP RECEPTOR GENE (GIPR) IN GIP-DEPENDENT CUSHING'S SYNDROME (CS)

2002 ◽  
Vol 28 (4) ◽  
pp. 755-756 ◽  
Author(s):  
S. R. Antonini ◽  
N. N'Diaye ◽  
P. Hamet ◽  
J. Tremblay ◽  
A. Lacroix
Keyword(s):  
Cushing’S Syndrome ◽  
Promoter Region ◽  
Receptor Gene ◽  
Cushing's Syndrome ◽  
Putative Promoter ◽  
Putative Promoter Region ◽  
Gip Receptor

scholarly journals Variation in the gene encoding Krüppel-like factor 7 influences body fat: studies of 14 818 Danes

2009 ◽  
Vol 160 (4) ◽  
pp. 603-609 ◽  
Author(s):  
Dorit P Zobel ◽  
Camilla H Andreasen ◽  
Kristoffer S Burgdorf ◽  
Ehm A Andersson ◽  
Annelli Sandbæk ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Promoter Region ◽  
Quantitative Traits ◽  
Nucleotide Polymorphisms ◽  
Putative Promoter ◽  
Gene Encoding ◽  
Putative Promoter Region ◽  
Pairwise Linkage Disequilibrium ◽  
Novel Association

ObjectiveKLF7encodes Krüppel-like factor (KLF) 7, a member of the KLF family of transcription factors, initially shown to play important roles in cellular development and differentiation, and reported to be specifically involved in adipogenesis. Several single nucleotide polymorphisms (SNPs) have been identified inKLF7, of which the A-allele of rs2302870 has been associated with type 2 diabetes in a Japanese population; however, a possible association ofKLF7SNPs with obesity has not been investigated. We aimed to identify variation in the putative promoter region, the coding regions, exon/intron boundaries, and 3′-UTR ofKLF7, and to examine identified variants in relation to obesity, type 2 diabetes, and related quantitative traits in Danish individuals.MethodsIdentified variants were investigated for association with type 2 diabetes in 8777 individuals and with obesity in 14 818 individuals.ResultsWe identified four common SNPs in low pairwise linkage disequilibrium; three in the putative promoter region (−1119 G>A, −963 C>A (rs7568369), and −614 G>A) and IVS2+35092 A>C (rs2302870). We failed to confirm an association between rs2302870 and type 2 diabetes. Neither was rs7568369 associated with type 2 diabetes; however, the minor A-allele of rs7568369 protected against obesity (OR=0.90 (0.84–0.96),P=0.001) and in studies of quantitative traits (n=5,535) the variant associated with decreased body mass index (P=0.002) and waist circumference (P=0.003). The −1119 G>A and −614 G>A variants were not associated with obesity or type 2 diabetes.ConclusionWe identified a novel association between the minor A-allele ofKLF7rs7568369 and protection against obesity in the Danish population.

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