Angiotensin Receptor Stimulation of Transforming Growth Factor-β in Rat Skin and Wound Healing

1994 ◽  
pp. 377-396 ◽  
Author(s):  
M. Ian Phillips ◽  
Birgitta Kimura ◽  
Robert Gyurko
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Angiotensin Receptor ◽  
Rat Skin ◽  
Receptor Stimulation ◽  
Stimulation Of

scholarly journals The MEK Pathway Is Required for Stimulation of p21WAF1/CIP1by Transforming Growth Factor-β

1999 ◽  
Vol 274 (50) ◽  
pp. 35381-35387 ◽  
Author(s):  
Patrick Pei-chih Hu ◽  
Xing Shen ◽  
David Huang ◽  
Yueyi Liu ◽  
Christopher Counter ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Stimulation Of

scholarly journals Proteolytic Release of Latent Transforming Growth Factor-β (TGF-β) Binding Protein-1 (LTBP-1) Fragment in Wound Healing

2009 ◽  
Vol 55 (3) ◽  
pp. 468-472
Author(s):  
Koji Mizuno ◽  
Hiroshi Wachi ◽  
Zenzo Isogai ◽  
Masahiko Yoneda ◽  
Satoshi Fujii ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Binding Protein ◽  
Transforming Growth Factor Β

Localization of Transforming Growth Factor-β- Expressing Cells and Comparison with Major Extracellular Components in Aural Cholesteatoma

1997 ◽  
Vol 106 (8) ◽  
pp. 669-673 ◽  
Author(s):  
Stephan Lang ◽  
Volker Schilling ◽  
Brigitte Mack ◽  
Barbara Wollenberg ◽  
Andreas Nerlich
Keyword(s):  
Extracellular Matrix ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Matrix Proteins ◽  
Matrix Interaction ◽  
Cell Matrix ◽  
Continuous Band ◽  
Enhanced Expression ◽  
Stimulation Of

Transforming growth factor-β (TGF-β) plays an important role in the regulation of extracellular matrix (ECM) deposition by stimulating the synthesis of individual matrix proteins like tenascin and fibronectin. Cholesteatoma shows significant changes in the ECM, supporting the view of adisturbed cell-matrix interaction. The purpose of our present study was to evaluate the distribution of TGF-β in comparison to the deposition of tenascin, fibronectin, and collagen as major components of the ECM in cholesteatoma (n = 12) by means of histochemistry and immunohistochemistry. We found TGF-P in lymphocytes and fibrohistiocytes in the stroma of 7 cholesteatomas. In corresponding sections, a marked expression of tenascin and fibronectin was seen manifesting as a continuous band along the epidermal-stromal junction, extending to the deeper stroma. In addition, in those cases of TGF-β expression, beginning collagen fibril formation was seen in adjacent deeper stroma layers, indicating beginning stromal fibrosis. These results suggest that TGF-β may be involved in the stimulation of the synthesis of tenascin, fibronectin, and collagen. Furthermore, the enhanced expression of tenascin and fibronectin provides evidence for a deregulated cell-matrix interaction in cholesteatoma associated with the enhanced proliferative process of cholesteatoma formation.

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