Cd44 and Splice Variants of Cd44 in Normal Differentiation and Tumor Progression

1993 ◽  
pp. 265-288 ◽  
Author(s):  
Peter Herrlich ◽  
Wolfgang Rudy ◽  
Martin Hofmann ◽  
Robert Arch ◽  
Margot Zöller ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Splice Variants ◽  
Normal Differentiation

scholarly journals Expression of cd44 splice variants in human cutaneous melanoma and melanoma cell lines is related to tumor progression and metastatic potential

1995 ◽  
Vol 64 (3) ◽  
pp. 182-188 ◽  
Author(s):  
Eveliene Manten-Horst ◽  
Erik H. J. Danen ◽  
Lia Smit ◽  
Margriet Snoek ◽  
I. Le Caroline Poole ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Cell Lines ◽  
Melanoma Cell ◽  
Cutaneous Melanoma ◽  
Splice Variants ◽  
Metastatic Potential ◽  
Melanoma Cell Lines

scholarly journals Involvement of Heparanase in Tumor Progression and Normal Differentiation

2003 ◽  
Vol 33 (1) ◽  
pp. 59-61 ◽  
Author(s):  
I. Vlodavsky ◽  
E. Zcharia ◽  
O. Goldshmidt ◽  
R. Eshel ◽  
B.-Z. Katz ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Normal Differentiation

scholarly journals The downregulation of type I IFN signaling in G-MDSCs under tumor conditions promotes their development towards an immunosuppressive phenotype

2022 ◽  
Vol 13 (1) ◽  
Author(s):  
Yingying Sun ◽  
Xiaoqing Han ◽  
Chao Shang ◽  
Yawei Wang ◽  
Boya Xu ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Suppressor Cells ◽  
Myeloid Cell ◽  
Mtor Pathway ◽  
Mouse Serum ◽  
Cytokine Signaling ◽  
Type I ◽  
Myeloid Derived Suppressor Cells ◽  
Immunosuppressive Microenvironment ◽  
Normal Differentiation

AbstractTumors modify myeloid cell differentiation and induce an immunosuppressive microenvironment. Granulocytic myeloid-derived suppressor cells (G-MDSCs), the main subgroup of myeloid-derived suppressor cells (MDSCs), are immature myeloid cells (IMCs) with immunosuppressive activity and exist in tumor-bearing hosts. The reason why these cells diverge from a normal differentiation pathway and are shaped into immunosuppressive cells remains unclear. Here, we reported that the increase of granulocyte colony-stimulating factor (G-CSF) in mouse serum with tumor progression encouraged G-MDSCs to obtain immunosuppressive traits in peripheral blood through the PI3K-Akt/mTOR pathway. Importantly, we found that downregulation of type I interferon (IFN-I) signaling in G-MDSCs was a prerequisite for their immunosuppressive effects. Suppressor of cytokine signaling (SOCS1), the action of which is dependent on IFN-I signaling, inhibited the activation of the PI3K-Akt/mTOR pathway by directly interacting with Akt, indicating that the differentiation of immunosuppressive G-MDSCs involves a transition from immune activation to immune tolerance. Our study suggests that increasing IFN-I signaling in G-MDSCs may be a strategy for reprograming immunosuppressive myelopoiesis and slowing tumor progression.

Expression of CD44 Splice Variants During Lymphocyte Activation and Tumor Progression

1994 ◽  
Vol 2 (3) ◽  
pp. 195-200 ◽  
Author(s):  
Arjan W. Griffioen ◽  
Eveliene Horst ◽  
Karl Heinz Heider ◽  
Vera J. M. Wielenga ◽  
GÜUnther R. Adolf ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Splice Variants ◽  
Lymphocyte Activation

Specific MUC1 Splice Variants Are Correlated With Tumor Progression in Esophageal Cancer

2014 ◽  
Vol 38 (8) ◽  
pp. 2052-2057 ◽  
Author(s):  
Kolsoum Rezaie Kahkhaie ◽  
Omeed Moaven ◽  
Mohammad Reza Abbaszadegan ◽  
Mehdi Montazer ◽  
Mehran Gholamin
Keyword(s):  
Esophageal Cancer ◽  
Tumor Progression ◽  
Splice Variants

Expression of splice variants; The human cholecystokinin-B receptor in association with gastrointestinal cancer

2001 ◽  
Vol 120 (5) ◽  
pp. A507-A507
Author(s):  
D KANG ◽  
Y WHANG ◽  
J YOO ◽  
I SONG ◽  
J OH ◽  
...  
Keyword(s):  
Gastrointestinal Cancer ◽  
Splice Variants

Expressions of cyclooxygenase-2 (COX-2) and prostaglandin E receptors (EPs) in gallbladder carcinoma (GBca)-association with tumor progression

2001 ◽  
Vol 120 (5) ◽  
pp. A573-A573
Author(s):  
J SHODA ◽  
T ASANO ◽  
T KAWAMOTO ◽  
Y MATSUZAKI ◽  
N TANAKA ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Gallbladder Carcinoma ◽  
Cyclooxygenase 2 ◽  
Prostaglandin E ◽  
Cox 2

150: Inhibition of Tumor Progression Using Antisense Oligonucleotide Targeting GLI2 in Androgen Independent Prostate Cancer

2007 ◽  
Vol 177 (4S) ◽  
pp. 51-51
Author(s):  
Shintaro Narita ◽  
Alan I. So ◽  
Shannon Sinnemann ◽  
Ladan Fazli ◽  
Eric G. Marcusson ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Tumor Progression ◽  
Antisense Oligonucleotide ◽  
Androgen Independent
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