Example: Fiber spinning

1998 ◽  
pp. 598-619
Author(s):  
Gregory C. Stangle
Keyword(s):  
Fiber Spinning

scholarly journals Recent Advances in Fiber–Hydrogel Composites for Wound Healing and Drug Delivery Systems

Antibiotics ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 248
Author(s):  
Marta O. Teixeira ◽  
Joana C. Antunes ◽  
Helena P. Felgueiras
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Mechanical Stability ◽  
Fiber Spinning ◽  
Comprehensive Overview ◽  
Triggered Drug Release ◽  
Medicinal Properties ◽  
Hydrogel Composites ◽  
Drug Incorporation ◽  
Stimuli Sensitive

In the last decades, much research has been done to fasten wound healing and target-direct drug delivery. Hydrogel-based scaffolds have been a recurrent solution in both cases, with some reaching already the market, even though their mechanical stability remains a challenge. To overcome this limitation, reinforcement of hydrogels with fibers has been explored. The structural resemblance of fiber–hydrogel composites to natural tissues has been a driving force for the optimization and exploration of these systems in biomedicine. Indeed, the combination of hydrogel-forming techniques and fiber spinning approaches has been crucial in the development of scaffolding systems with improved mechanical strength and medicinal properties. In this review, a comprehensive overview of the recently developed fiber–hydrogel composite strategies for wound healing and drug delivery is provided. The methodologies employed in fiber and hydrogel formation are also highlighted, together with the most compatible polymer combinations, as well as drug incorporation approaches creating stimuli-sensitive and triggered drug release towards an enhanced host response.

Physical Microfabrication of Shape-Memory Polymer Systems via Bicomponent Fiber Spinning

2016 ◽  
Vol 37 (22) ◽  
pp. 1837-1843 ◽  
Author(s):  
Syamal S. Tallury ◽  
Behnam Pourdeyhimi ◽  
Melissa A. Pasquinelli ◽  
Richard J. Spontak
Keyword(s):  
Shape Memory ◽  
Shape Memory Polymer ◽  
Fiber Spinning ◽  
Polymer Systems ◽  
Bicomponent Fiber

Preparation of Fibrous Scaffolds Containing Calcium and Silicon Species

2011 ◽  
Vol 493-494 ◽  
pp. 840-843
Author(s):  
Akiko Obata ◽  
Hiroki Ozasa ◽  
Julian R. Jones ◽  
Toshihiro Kasuga
Keyword(s):  
Tissue Engineering ◽  
Hybrid Materials ◽  
Fiber Diameter ◽  
Fiber Spinning ◽  
High Porosity ◽  
Cotton Wool ◽  
Tissue Engineering Scaffolds ◽  
Large Defect ◽  
Nanofibrous Structure ◽  
Versatile Technique

Materials for bone defect filling should have 3D macroporous structure and be flexible to be packed into complex defects with limited entrance space. Tissue engineering scaffolds should also mimic the structure and morphology of the host tissue. Electrospinning is a versatile technique to produce materials with micro/nanofibrous structure, large surface area and high porosity. Electrospun materials are very promising for tissue engineering due to the possibility of mimicking the fibrous structure of natural extra cellular matrix (ECM). Siloxane-containing vaterite (SiV)/poly (L-lactic acid) (PLLA) hybrids (SiPVH) with controlled silicate and calcium ions releasing ability has been produced in our group. They have also demonstrated good cell infiltration into the electrospun hybrid materials that had fiber diameters greater than 10 μm. However, these electrospun hybrid materials were planar (2D) and are not suitable for large defect regeneration. In this work, the development of a fabrication technique for the production of 3D cotton wool-like structures with fiber diameter in the range of 10 μm was performed. SiPVH cotton wool-like structure containing 0, 30 and 60 wt % SiV were prepared by blowing air in the direction perpendicular to fiber spinning. Si-vaterite particles and small pores were found on the surface of the fibers. The fiber diameter of the samples were found to be in the range of 10 ~ 20 μm. Stretch tests showed more than 50 % extension for the SiPVH cotton wool-like material containing 30 wt % SiV (SiPVH30). This extension was similar to that observed for the PLLA cotton wool-like material. The results suggest that the SiPVH30 cotton wool-like material are good candidates for bone tissue engineering scaffolds.

scholarly journals Hierarchical spidroin micellar nanoparticles as the fundamental precursors of spider silks

2018 ◽  
Vol 115 (45) ◽  
pp. 11507-11512 ◽  
Author(s):  
Lucas R. Parent ◽  
David Onofrei ◽  
Dian Xu ◽  
Dillan Stengel ◽  
John D. Roehling ◽  
...  
Keyword(s):  
Liquid Crystalline ◽  
Spider Silk ◽  
Fiber Spinning ◽  
Fiber Formation ◽  
Natural Material ◽  
Physical Form ◽  
Spinning Process ◽  
Black Widow Spiders ◽  
Spider Silks

Many natural silks produced by spiders and insects are unique materials in their exceptional toughness and tensile strength, while being lightweight and biodegradable–properties that are currently unparalleled in synthetic materials. Myriad approaches have been attempted to prepare artificial silks from recombinant spider silk spidroins but have each failed to achieve the advantageous properties of the natural material. This is because of an incomplete understanding of the in vivo spidroin-to-fiber spinning process and, particularly, because of a lack of knowledge of the true morphological nature of spidroin nanostructures in the precursor dope solution and the mechanisms by which these nanostructures transform into micrometer-scale silk fibers. Herein we determine the physical form of the natural spidroin precursor nanostructures stored within spider glands that seed the formation of their silks and reveal the fundamental structural transformations that occur during the initial stages of extrusion en route to fiber formation. Using a combination of solution phase diffusion NMR and cryogenic transmission electron microscopy (cryo-TEM), we reveal direct evidence that the concentrated spidroin proteins are stored in the silk glands of black widow spiders as complex, hierarchical nanoassemblies (∼300 nm diameter) that are composed of micellar subdomains, substructures that themselves are engaged in the initial nanoscale transformations that occur in response to shear. We find that the established micelle theory of silk fiber precursor storage is incomplete and that the first steps toward liquid crystalline organization during silk spinning involve the fibrillization of nanoscale hierarchical micelle subdomains.

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