Theory of Hormone-Receptor Interaction

1973 ◽  
pp. 342-364 ◽  
Author(s):  
D. Rodbard
Keyword(s):  
Hormone Receptor ◽  
Receptor Interaction

Modification of Deoxyribonucleic Acid-Thyroid Hormone Receptor Interaction by Histones*

Endocrinology ◽  
1987 ◽  
Vol 121 (3) ◽  
pp. 893-899 ◽  
Author(s):  
KAZUO ICHIKAWA ◽  
STEVEN BENTLEY ◽  
MARTIN FEE ◽  
LESLIE J. DEGROOT
Keyword(s):  
Thyroid Hormone ◽  
Hormone Receptor ◽  
Deoxyribonucleic Acid ◽  
Thyroid Hormone Receptor ◽  
Receptor Interaction

Growth Hormone Receptor Interaction with Jak Proteins Differs Between Tissues

2001 ◽  
Vol 21 (2) ◽  
pp. 75-83 ◽  
Author(s):  
Gunnel Hellgren ◽  
Kerstin Albertsson-Wikland ◽  
Håkan Billig ◽  
Lena M.S. Carlsson ◽  
Björn Carlsson
Keyword(s):  
Growth Hormone ◽  
Hormone Receptor ◽  
Growth Hormone Receptor ◽  
Receptor Interaction

Luteinizing Hormone-Receptor Interaction in the Testis: Progressive Decrease in Reversibility of the Hormone-Receptor Complex

Endocrinology ◽  
1980 ◽  
Vol 107 (6) ◽  
pp. 1980-1988 ◽  
Author(s):  
MOHAN KATIKINENI ◽  
TERRY F. DAVIES ◽  
ILPO T. HUHTANIEMI ◽  
KEVIN J. CATT
Keyword(s):  
Luteinizing Hormone ◽  
Hormone Receptor ◽  
Luteinizing Hormone Receptor ◽  
Receptor Interaction ◽  
Receptor Complex ◽  
Progressive Decrease

scholarly journals Structural Requirements for the Action of Neurohypophyseal Hormones upon the Isolated Amphibian Urinary Bladder

1963 ◽  
Vol 46 (6) ◽  
pp. 1171-1189 ◽  
Author(s):  
Howard Rasmussen ◽  
Irving L. Schwartz ◽  
Richard Young ◽  
Julien Marc-Aurele
Keyword(s):  
Urinary Bladder ◽  
Hormone Receptor ◽  
Receptor Site ◽  
Arginine Vasotocin ◽  
Ion Concentration ◽  
Intrinsic Activity ◽  
Receptor Interaction ◽  
Hydrogen Ion Concentration ◽  
Amphibian Urinary Bladder ◽  
Ionizable Groups

The response of the isolated amphibian urinary bladder to thirty-four structural analogs of arginine vasotocin was determined in an effort to define the physiological significance of specific structural groups on the hormone molecule. All but one of the analogs tested possessed full intrinsic activity in this system but varied greatly in their affinity for the receptor site. An analysis of the effect of changes in hydrogen ion concentration upon the response of the bladder to oxytocin was performed in order to determine the number and nature of the ionizable groups involved in hormone receptor interaction. Two ionizable groups with apparent pK's of 7.1 and 7.75 were found to be important in determining the magnitude of the hormonal response. On the basis of the results it was postulated that hormone-receptor interaction can be considered a two-step process: (a) The binding or attachment of hormone to receptor site through ionic, hydrogen, and hydrophobic bonds and (b) a disulfide interchange reaction between hormonal disulfide and receptor sulfhydryl. The latter step is considered to be the reaction which initiates the chain of events leading to the observed change in permeability.

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