Molecular Mechanisms of Translational Control during the Early Development of Xenopus laevis

1987 ◽  
pp. 111-139 ◽  
Author(s):  
Joel D. Richter
Keyword(s):  
Xenopus Laevis ◽  
Early Development ◽  
Translational Control ◽  
Molecular Mechanisms

Translational Control during Early Development

1997 ◽  
Vol 7 (1-2) ◽  
pp. 73-94 ◽  
Author(s):  
Barbara Stebbins-Boaz ◽  
Joel D. Richter
Keyword(s):  
Early Development ◽  
Translational Control

Early development of dorsal column-medial lemniscal projections in the clawed toad, Xenopus laevis

1993 ◽  
Vol 74 (2) ◽  
pp. 291-294 ◽  
Author(s):  
A. Múñoz ◽  
R. de Boer-Van Huizen ◽  
I. Bergervoet-Vernooy ◽  
H.J. ten Donkelaar
Keyword(s):  
Xenopus Laevis ◽  
Early Development ◽  
Dorsal Column

scholarly journals The Role of Translation Initiation Regulation in Haematopoiesis

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Godfrey Grech ◽  
Marieke von Lindern
Keyword(s):  
Gene Expression ◽  
Translation Initiation ◽  
Translational Control ◽  
Molecular Mechanisms ◽  
Rna Binding ◽  
Regulation Of Gene Expression ◽  
Mrna Translation ◽  
Translation Control ◽  
Haematological Disorders

Organisation of RNAs into functional subgroups that are translated in response to extrinsic and intrinsic factors underlines a relatively unexplored gene expression modulation that drives cell fate in the same manner as regulation of the transcriptome by transcription factors. Recent studies on the molecular mechanisms of inflammatory responses and haematological disorders indicate clearly that the regulation of mRNA translation at the level of translation initiation, mRNA stability, and protein isoform synthesis is implicated in the tight regulation of gene expression. This paper outlines how these posttranscriptional control mechanisms, including control at the level of translation initiation factors and the role of RNA binding proteins, affect hematopoiesis. The clinical relevance of these mechanisms in haematological disorders indicates clearly the potential therapeutic implications and the need of molecular tools that allow measurement at the level of translational control. Although the importance of miRNAs in translation control is well recognised and studied extensively, this paper will exclude detailed account of this level of control.

scholarly journals Early development of apoplastic barriers and molecular mechanisms in juvenile maize roots in response to La2O3 nanoparticles

2019 ◽  
Vol 653 ◽  
pp. 675-683 ◽  
Author(s):  
Le Yue ◽  
Feiran Chen ◽  
Kaiqiang Yu ◽  
Zhenggao Xiao ◽  
Xiaoyu Yu ◽  
...  
Keyword(s):  
Early Development ◽  
Molecular Mechanisms ◽  
Maize Roots ◽  
Apoplastic Barriers

Cloning of the Xenopus laevis cdk2 promoter and functional analysis in oocytes and during early development

Gene ◽  
1994 ◽  
Vol 151 (1-2) ◽  
pp. 81-88 ◽  
Author(s):  
Michelle Olive ◽  
Nadine Thézé ◽  
Michel Philippe ◽  
Jean-Paul Le Pennec ◽  
Hubert Lerivray
Keyword(s):  
Functional Analysis ◽  
Xenopus Laevis ◽  
Early Development

scholarly journals Toxic effects of carbendazim andn-butyl isocyanate, metabolites of the fungicide benomyl, on early development in the African clawed frog,Xenopus laevis

2008 ◽  
Vol 23 (1) ◽  
pp. 131-144 ◽  
Author(s):  
Chun-Sik Yoon ◽  
Jung-Hyo Jin ◽  
Joo-Hung Park ◽  
Chang-Yeol Yeo ◽  
Song-Ja Kim ◽  
...  
Keyword(s):  
Xenopus Laevis ◽  
Early Development ◽  
Toxic Effects ◽  
African Clawed Frog ◽  
Clawed Frog

Chromosome replication in early development of Xenopus laevis

Development ◽  
1985 ◽  
Vol 89 (Supplement) ◽  
pp. 285-296
Author(s):  
R. A. Laskey
Keyword(s):  
Dna Replication ◽  
Xenopus Laevis ◽  
Early Development ◽  
Chromosome Replication ◽  
Chromatin Assembly

Eggs of Xenopus laevis contain exceptionally large amounts of materials involved in chromosome replication. This maternal stockpile allows an embryo to produce about 80 000 cells in less than 24 h. The adaptations which achieve this involve the mechanisms of both DNA replication and chromatin assembly.

XCL100, an inducible nuclear MAP kinase phosphatase from Xenopus laevis: its role in MAP kinase inactivation in differentiated cells and its expression during early development

1995 ◽  
Vol 108 (8) ◽  
pp. 2885-2896 ◽  
Author(s):  
T. Lewis ◽  
L.A. Groom ◽  
A.A. Sneddon ◽  
C. Smythe ◽  
S.M. Keyse
Keyword(s):  
Xenopus Laevis ◽  
Map Kinase ◽  
Early Development ◽  
Nuclear Translocation ◽  
Cell Types ◽  
Differentiated Cells ◽  
Serum Stimulation ◽  
Transient Activation ◽  
Map Kinase Phosphatase

We have cloned the Xenopus laevis homologue (XCL100) of the human CL100 (Thr/Tyr) MAP kinase phosphatase. Expression of the XCL100 mRNA and protein is inducible by serum stimulation and oxidative/heat stress in a X. laevis kidney cell line. In contrast, XCL100 is constitutively expressed in growing Xenopus oocytes. Recombinant XCL100 protein is able to dephosphorylate both tyrosine and threonine residues of activated p42 MAP kinase in vitro and both the Xenopus and human CL100 proteins were localised predominantly in the nucleus in transfected COS-1 cells. As nuclear translocation of activated MAP kinase is necessary for some of its essential functions in proliferation and cell differentiation our results indicate a role for CL100 in the regulation of these nuclear signalling events. In Xenopus kidney cells both heat shock and serum stimulation lead to transient activation of MAP kinase. However, in contrast to results previously reported from studies on mammalian fibroblasts the inactivation of MAP kinase in these epitheloid cells is rapid and is not dependent on synthesis of new protein. These results indicate that the induction of CL100 (or CL100-like enzymes) may not be required for MAP kinase inactivation in all cell types. Finally, during early embryogenesis, levels of XCL100 mRNA are greatly increased at the mid-blastula transition, suggesting that this enzyme may be involved in the regulation of MAP kinase activity during early development.

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