Role of Membrane Lipid Composition in Radiation- Induced Death of Mammalian Cells

1987 ◽  
pp. 29-43 ◽  
Author(s):  
A. W. T. Konings
Keyword(s):  
Lipid Composition ◽  
Mammalian Cells ◽  
Membrane Lipid ◽  
Membrane Lipid Composition ◽  
Radiation Induced

Dietary Selenium or Zinc Supplementation Restores Brain Lipid Composition and Membrane Fluidity in Protein-Undernourished Rats

2016 ◽  
Vol 38 (6) ◽  
pp. 397-406
Author(s):  
Olusegun L. Adebayo ◽  
Bamidele A. Salau ◽  
Rajat Sandhir ◽  
Gbenga A. Adenuga
Keyword(s):  
Membrane Fluidity ◽  
Lipid Composition ◽  
Zinc Supplementation ◽  
Protective Role ◽  
Membrane Lipid ◽  
Limited Information ◽  
Total Lipids ◽  
Major Focus ◽  
Membrane Lipid Composition

Studies have shown that protein undernutrition (PU) modifies the membrane lipid composition in the intestine and liver, as well as in plasma and other areas. However, there is limited information on the effect of PU on synaptosomal membrane lipid composition and fluidity and the protective role of selenium (Se) and zinc (Zn), which is a major focus of the present study. For 10 weeks, rats were fed diets containing 16% casein, which constituted the adequate protein diet, or 5% casein, representing the PU diet. The animals were supplemented with Se and Zn at a concentration of 0.15 and 227 mg L-1, respectively, in drinking water for 3 weeks. The results showed a significant increase in total lipids, glycolipids, triglycerides, cholesterol, and the cholesterol/phospholipid (Chol/PL) ratio, and a significant reduction in phospholipids and membrane fluidity. Se and Zn supplementation to PU rats, however, significantly lowered total lipids, glycolipids, triglycerides, cholesterol, and the Chol/PL ratio, while phospholipids and membrane fluidity were significantly restored. It is concluded that a perturbed lipid composition induced by PU affects the membrane structure and fluidity, which in turn influences membrane functions. The study suggests that Se and Zn supplementation might be beneficial in restoring the lipid dyshomeostasis associated with PU.

scholarly journals P4-199: Role of γ secretase in the cellular membrane lipid composition

2008 ◽  
Vol 4 ◽  
pp. T729-T730
Author(s):  
Jessica Hommes ◽  
Jochen Walter ◽  
Bernadette Breiden ◽  
Irfan Y. Tamboli ◽  
Günter Schwarzmann
Keyword(s):  
Lipid Composition ◽  
Cellular Membrane ◽  
Membrane Lipid ◽  
Membrane Lipid Composition

scholarly journals Role of plasma membrane lipid composition on cellular homeostasis: learning from cell line models expressing fatty acid desaturases

2014 ◽  
Vol 46 (4) ◽  
pp. 273-282 ◽  
Author(s):  
M. S. Jaureguiberry ◽  
M. A. Tricerri ◽  
S. A. Sanchez ◽  
G. S. Finarelli ◽  
M. A. Montanaro ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Fatty Acid ◽  
Cell Line ◽  
Lipid Composition ◽  
Membrane Lipid ◽  
Fatty Acid Desaturases ◽  
Cellular Homeostasis ◽  
Membrane Lipid Composition ◽  
Plasma Membrane Lipid

Membrane Lipid Composition and the Interaction of Pardaxin: The Role of Cholesterol

2006 ◽  
Vol 13 (1) ◽  
pp. 1-5 ◽  
Author(s):  
R. F. Epand ◽  
A. Ramamoorthy ◽  
R. M. Epand
Keyword(s):  
Lipid Composition ◽  
Membrane Lipid ◽  
Membrane Lipid Composition

Membrane Lipid Composition and the Interaction of Pardaxin: The Role of Cholesterol

2006 ◽  
Vol 13 (1) ◽  
pp. 1-5 ◽  
Author(s):  
R. Epand ◽  
A. Ramamoorthy ◽  
R. Epand
Keyword(s):  
Lipid Composition ◽  
Membrane Lipid ◽  
Membrane Lipid Composition
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