Analysis of Mitochondrial DNA Copy Number and Its Regulation Through DNA Methylation of POLGA

2016 ◽  
pp. 131-141 ◽  
Author(s):  
Xin Sun ◽  
William Lee ◽  
Vijesh Vaghjiani ◽  
Justin C. St. John
Keyword(s):  
Dna Methylation ◽  
Mitochondrial Dna ◽  
Copy Number ◽  
Dna Copy Number ◽  
Mitochondrial Dna Copy Number

scholarly journals Mitochondrial DNA methylation and copy number predict body composition in a young female population

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Laura Bordoni ◽  
Vanessa Smerilli ◽  
Cinzia Nasuti ◽  
Rosita Gabbianelli
Keyword(s):  
Dna Methylation ◽  
Body Composition ◽  
Mitochondrial Dna ◽  
Copy Number ◽  
Buccal Swab ◽  
Dna Copy Number ◽  
Female Population ◽  
Mitochondrial Dna Copy Number ◽  
Buccal Swabs ◽  
D Loop

Abstract Background Since both genomic and environmental factors are involved in obesity etiology, several studies about the influence of adiposity on both nuclear DNA and mitochondrial DNA methylation patterns have been carried out. Nevertheless, few evidences exploring the usage of buccal swab samples to study mitochondrial DNA epigenetics can be found in literature. Methods In this study, mitochondrial DNA from buccal swabs collected from a young Caucasian population (n = 69) have been used to examine potential correlation between mitochondrial DNA copy number and methylation with body composition (BMI, WHtR and bioimpedance measurements). Results A negative correlation between mitochondrial DNA copy number and BMI was measured in females (p = 0.028), but not in males. The mean percentage of D-loop methylation is significantly higher in overweight than in lean female subjects (p = 0.003), and a specific CpG located in the D-loop shows per se an association with impaired body composition (p = 0.004). Body composition impairment is predicted by a combined variable including mtDNA copy number and the D-loop methylation (AUC = 0.785; p = 0.009). Conclusions This study corroborates the hypothesis that mitochondrial DNA carries relevant information about body composition. However, wider investigations able to validate the usage of mtDNA methylation from buccal swabs as a biomarker are warranted.

scholarly journals Mitochondrial DNA copy number is regulated by DNA methylation and demethylation of POLGA in stem and cancer cells and their differentiated progeny

2015 ◽  
Vol 6 (2) ◽  
pp. e1664-e1664 ◽  
Author(s):  
W Lee ◽  
J Johnson ◽  
D J Gough ◽  
J Donoghue ◽  
G L M Cagnone ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Mitochondrial Dna ◽  
Cancer Cells ◽  
Copy Number ◽  
Dna Copy Number ◽  
Mitochondrial Dna Copy Number

scholarly journals Mitochondrial DNA copy number is regulated in a tissue specific manner by DNA methylation of the nuclear-encoded DNA polymerase gamma A

2012 ◽  
Vol 40 (20) ◽  
pp. 10124-10138 ◽  
Author(s):  
Richard D. W. Kelly ◽  
Arsalan Mahmud ◽  
Matthew McKenzie ◽  
Ian A. Trounce ◽  
Justin C. St John
Keyword(s):  
Dna Methylation ◽  
Mitochondrial Dna ◽  
Dna Polymerase ◽  
Copy Number ◽  
Dna Copy Number ◽  
Tissue Specific ◽  
Polymerase Gamma ◽  
Dna Polymerase Gamma ◽  
Mitochondrial Dna Copy Number ◽  
Specific Manner

scholarly journals Association of DNA Methylation and Mitochondrial DNA Copy Number with Human Semen Quality1

2014 ◽  
Vol 91 (4) ◽  
Author(s):  
Meiping Tian ◽  
Huaqiong Bao ◽  
Francis L. Martin ◽  
Jie Zhang ◽  
Liangpo Liu ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Mitochondrial Dna ◽  
Copy Number ◽  
Human Semen ◽  
Dna Copy Number ◽  
Mitochondrial Dna Copy Number

Prenatal exposure to bisphenol S and altered newborn mitochondrial DNA copy number in a baby cohort study: Sex-specific associations

Chemosphere ◽  
2021 ◽  
Vol 263 ◽  
pp. 128019
Author(s):  
Lulin Wang ◽  
Lulu Song ◽  
Bingqing Liu ◽  
Mingyang Wu ◽  
Yunyun Liu ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Cohort Study ◽  
Prenatal Exposure ◽  
Copy Number ◽  
Dna Copy Number ◽  
Bisphenol S ◽  
Mitochondrial Dna Copy Number
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