Visualizing Cancer Cell Chemotaxis and Invasion in 2D and 3D

2016 ◽  
pp. 217-228 ◽  
Author(s):  
Olivia Susanto ◽  
Andrew J. Muinonen-Martin ◽  
Max Nobis ◽  
Robert H. Insall
Keyword(s):  
Cancer Cell ◽  
2D And 3D ◽  
Cell Chemotaxis

Isolation of ketomycin from Actinomycetes as an inhibitor of 2D and 3D cancer cell invasion

2018 ◽  
Vol 72 (3) ◽  
pp. 148-154 ◽  
Author(s):  
Yinzhi Lin ◽  
Yue Chen ◽  
Tamami Ukaji ◽  
Shoshiro Okada ◽  
Kazuo Umezawa
Keyword(s):  
Cancer Cell ◽  
Cell Invasion ◽  
Cancer Cell Invasion ◽  
2D And 3D

scholarly journals Interactome Analysis Reveals that C1QBP (complement component 1, q subcomponent binding protein) Is Associated with Cancer Cell Chemotaxis and Metastasis

2013 ◽  
Vol 12 (11) ◽  
pp. 3199-3209 ◽  
Author(s):  
Xiaofang Zhang ◽  
Fei Zhang ◽  
Lin Guo ◽  
Yanping Wang ◽  
Peng Zhang ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Binding Protein ◽  
Complement Component ◽  
Cell Chemotaxis

scholarly journals Cdc42 Mediates Cancer Cell Chemotaxis in Perineural Invasion

2020 ◽  
Vol 18 (6) ◽  
pp. 913-925
Author(s):  
Natalya Chernichenko ◽  
Tatiana Omelchenko ◽  
Sylvie Deborde ◽  
Richard L. Bakst ◽  
Shizhi He ◽  
...  
Keyword(s):  
Cancer Cell ◽  
Perineural Invasion ◽  
Cell Chemotaxis

Differential effects of EGF gradient profiles on MDA-MB-231 breast cancer cell chemotaxis

2004 ◽  
Vol 300 (1) ◽  
pp. 180-189 ◽  
Author(s):  
Shur-Jen Wang ◽  
Wajeeh Saadi ◽  
Francis Lin ◽  
Connie Minh-Canh Nguyen ◽  
Noo Li Jeon
Keyword(s):  
Breast Cancer ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Differential Effects ◽  
Cell Chemotaxis

A parallel-gradient microfluidic chamber for quantitative analysis of breast cancer cell chemotaxis

2006 ◽  
Vol 8 (2) ◽  
pp. 109-118 ◽  
Author(s):  
Wajeeh Saadi ◽  
Shur-Jen Wang ◽  
Francis Lin ◽  
Noo Li Jeon
Keyword(s):  
Breast Cancer ◽  
Quantitative Analysis ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Microfluidic Chamber ◽  
Cell Chemotaxis

scholarly journals Differences of statin activity in 2D and 3D pancreatic cancer cell cultures

2017 ◽  
Vol Volume 11 ◽  
pp. 3273-3280 ◽  
Author(s):  
Miglė Paškevičiūtė ◽  
Vilma Petrikaitė
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cell ◽  
Cell Cultures ◽  
Pancreatic Cancer Cell ◽  
2D And 3D

scholarly journals Synergy between Photodynamic Therapy and Dactinomycin Chemotherapy in 2D and 3D Ovarian Cancer Cell Cultures

2020 ◽  
Vol 21 (9) ◽  
pp. 3203 ◽  
Author(s):  
Layla Mohammad Hadi ◽  
Elnaz Yaghini ◽  
Alexander J. MacRobert ◽  
Marilena Loizidou
Keyword(s):  
Ovarian Cancer ◽  
Photodynamic Therapy ◽  
Cell Lines ◽  
Cancer Cell ◽  
Low Dose ◽  
Ovarian Cancer Cell ◽  
3D Culture ◽  
Ovarian Cancer Cell Lines ◽  
Cell Kill ◽  
2D And 3D

In this study we explored the efficacy of combining low dose photodynamic therapy using a porphyrin photosensitiser and dactinomycin, a commonly used chemotherapeutic agent. The studies were carried out on compressed collagen 3D constructs of two human ovarian cancer cell lines (SKOV3 and HEY) versus their monolayer counterparts. An amphiphilc photosensitiser was employed, disulfonated tetraphenylporphine, which is not a substrate for ABC efflux transporters that can mediate drug resistance. The combination treatment was shown to be effective in both monolayer and 3D constructs of both cell lines, causing a significant and synergistic reduction in cell viability. Compared to dactinomycin alone or PDT alone, higher cell kill was found using 2D monolayer culture vs. 3D culture for the same doses. In 3D culture, the combination therapy resulted in 10 and 22 times higher cell kill in SKOV3 and HEY cells at the highest light dose compared to dactinomycin monotherapy, and 2.2 and 5.5 times higher cell kill than PDT alone. The combination of low dose PDT and dactinomycin appears to be a promising way to repurpose dactinomycin and widen its therapeutic applications.

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