Bone Imaging: Platelet Formation Dynamics

2018 ◽  
pp. 23-28
Author(s):  
Asuka Sakata ◽  
Satoshi Nishimura
Keyword(s):  
Bone Imaging ◽  
Formation Dynamics ◽  
Platelet Formation

INVESTIGATION OF PLASMA FORMATION DYNAMICS AND PROPERTIES OF UNDEREXPANDED SUPERSONIC EROSIVE LASER PLASMA FLARES

1979 ◽  
Vol 40 (C7) ◽  
pp. C7-761-C7-762
Author(s):  
G. I. Bakanovich ◽  
L. Ya. Min'ko ◽  
A. N. Chumakov
Keyword(s):  
Laser Plasma ◽  
Plasma Formation ◽  
Formation Dynamics ◽  
Erosive Laser Plasma

99mTc-DPD SPECT/CT for localisation of inflammatory and chronic osteoarthritis of the foot and ankle

2016 ◽  
Vol 55 (04) ◽  
pp. 145-150 ◽  
Author(s):  
Lutz Freudenberg ◽  
Hinrich Wieder ◽  
Jens Stollfuss
Keyword(s):  
Bone Metabolism ◽  
Late Phase ◽  
Blood Pool ◽  
Phase Imaging ◽  
Bone Imaging ◽  
Foot And Ankle ◽  
Planar Imaging ◽  
Selective Treatment ◽  
Complex Anatomy ◽  
Three Phase

SummaryAim: The precise localisation of osteoarthritic and inflammatory changes is crucial for selective treatment planning of radiosynovectomy (RSV). The present study evaluated the diagnostic accuracy of planar bone imaging and SPECT for the detection of pathological bone metabolism and inflammation in joints of the foot and ankle, compared with SPECT/CT. Patients, methods: 39 patients (mean age 65.6 ± 11.1 years) with suspected inflammatory osteoarthritis underwent SPECT/CT of the feet. After injection of approximately 500 MBq 99mTc DPD, all patients had three-phase planar bone imaging and late-phase hybrid SPECT/CT. late-phase SPECT, and CT of the foot. Increased bone metabolism and blood-pool was assigned to the respective joint of the fore-, mid-, and hindfoot, using SPECT/CT as the reference standard. Results: Overall, SPECT had a higher sensitivity than planar imaging (0.80 vs 0.68, n.s.). The advantage of SPECT was most obvious in the anatomically complex midfoot area (0.63 vs 0.26, p < 0.05) and less obvious in the forefoot (0.85 vs 0.79, n.s.) and hindfoot (0.89 vs 0.89, n.s.). The overall concordance (Cohen`s Kappa) between SPECT/CT and planar (late-phase) imaging and SPECT was high for the forefoot and the hindfoot (planar: 0.78/0.81; SPECT 0.86/0.88) and comparatively low for the midfoot (planar: 0.27; SPECT 0.61). Conclusion: SPECT was significantly superior to planar bone imaging for the detection of joint lesions in the midfoot. The differences between SPECT and planar imaging in the fore- and hindfoot were not significant, most likely due to the inherently less complex anatomy. Compared with SPECT alone, a benefit from the use of SPECT/CT can be observed in the midfoot region where it facilitates the identification of the correct joint for RSV.

scholarly journals Impact of supervised beego, a traditional Chinese water-only fasting, on thrombosis and haemostasis

2021 ◽  
pp. bmjnph-2020-000183
Author(s):  
Yixuan Fang ◽  
Yue Gu ◽  
Chen Zhao ◽  
Yaqi Lv ◽  
Jiawei Qian ◽  
...  
Keyword(s):  
Biological Effects ◽  
Selective Reduction ◽  
Coagulation Factors ◽  
Normal Diet ◽  
Non Invasive ◽  
Cholesterol Levels ◽  
Thrombosis Risk ◽  
Abdominal Breathing ◽  
Mediated Reduction ◽  
Platelet Formation

Beego is a traditional Chinese complete water-only fasting practice initially developed for spiritual purposes, later extending to physical fitness purposes. Beego notably includes a psychological induction component that includes meditation and abdominal breathing, light body exercise and ends with a specific gradual refeeding program before returning to a normal diet. Beego has regained its popularity in recent decades in China as a strategy for helping people in subhealthy conditions or with metabolic syndrome, but we are unaware of any studies examining the biological effects of this practice. To address this, we here performed a longitudinal study of beego comprising fasting (7 and 14 day cohorts) and a 7-day programmed refeeding phase. In addition to detecting improvements in cardiovascular physiology and selective reduction of blood pressure in hypertensive subjects, we observed that beego decreased blood triacylglycerol (TG) selectively in TG-high subjects and increased cholesterol in all subjects during fasting; however, the cholesterol levels were normalised after completion of the refeeding program. Strikingly, beego reduced platelet formation, activation, aggregation and degranulation, resulting in an alleviated thrombosis risk, yet maintained haemostasis by sustaining levels of coagulation factors and other haemostatic proteins. Mechanistically, we speculate that downregulation of G6B and MYL9 may influence the observed beego-mediated reduction in platelets. Fundamentally, our study supports that supervised beego reduces thrombosis risk without compromising haemostasis capacity. Moreover, our results support that beego under medical supervision can be implemented as non-invasive intervention for reducing thrombosis risk, and suggest several lines of intriguing inquiry for future studies about this fasting practice (http://www.chictr.org.cn/index.aspx, number, ChiCTR1900027451).

[99mTc]Tc-Phosphate-buffer system as a potential tracer for bone imaging

2021 ◽  
Author(s):  
Nara Caroline Pereira ◽  
Juliana de Oliveira Silva ◽  
Frederico B. De Sousa ◽  
Sued Eustáquio Mendes Miranda ◽  
Daniel Crístian Ferreira Soares ◽  
...  
Keyword(s):  
Phosphate Buffer ◽  
Buffer System ◽  
Bone Imaging

scholarly journals SLPI is a critical mediator that controls PTH-induced bone formation

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Akito Morimoto ◽  
Junichi Kikuta ◽  
Keizo Nishikawa ◽  
Takao Sudo ◽  
Maki Uenaka ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Bone Resorption ◽  
Bone Formation ◽  
Protease Inhibitor ◽  
Bone Metabolism ◽  
Serine Protease ◽  
Serine Protease Inhibitor ◽  
Secretory Leukocyte Protease Inhibitor ◽  
Bone Imaging ◽  
Genetic Ablation

AbstractOsteoclastic bone resorption and osteoblastic bone formation/replenishment are closely coupled in bone metabolism. Anabolic parathyroid hormone (PTH), which is commonly used for treating osteoporosis, shifts the balance from osteoclastic to osteoblastic, although it is unclear how these cells are coordinately regulated by PTH. Here, we identify a serine protease inhibitor, secretory leukocyte protease inhibitor (SLPI), as a critical mediator that is involved in the PTH-mediated shift to the osteoblastic phase. Slpi is highly upregulated in osteoblasts by PTH, while genetic ablation of Slpi severely impairs PTH-induced bone formation. Slpi induction in osteoblasts enhances its differentiation, and increases osteoblast–osteoclast contact, thereby suppressing osteoclastic function. Intravital bone imaging reveals that the PTH-mediated association between osteoblasts and osteoclasts is disrupted in the absence of SLPI. Collectively, these results demonstrate that SLPI regulates the communication between osteoblasts and osteoclasts to promote PTH-induced bone anabolism.

scholarly journals Formation, dynamics, and long-term stability of Mn- and Fe-promoted Rh/SiO2 catalysts in CO hydrogenation

2021 ◽  
Author(s):  
Phil Preikschas ◽  
Julia Bauer ◽  
Kristian Knemeyer ◽  
Raoul Naumann d'Alnoncourt ◽  
Ralph Krähnert ◽  
...  
Keyword(s):  
Co Hydrogenation ◽  
Term Stability ◽  
Fossil Carbon ◽  
Long Term Stability ◽  
Formation Dynamics

The conversion of syngas (CO/H2) to ethanol (StE) is one promising example to generate a high-value fuel and key intermediate for various base chemicals, preferably from non-fossil carbon resources. Rh-based...

scholarly journals Proplatelets and stress platelets

Blood ◽  
1987 ◽  
Vol 69 (2) ◽  
pp. 522-528 ◽  
Author(s):  
M Tong ◽  
P Seth ◽  
DG Penington
Keyword(s):  
Bone Marrow ◽  
Platelet Rich Plasma ◽  
Early Period ◽  
Platelet Volume ◽  
Plasma Exposure ◽  
Functional Characteristics ◽  
Platelet Production ◽  
Relationship Of ◽  
The Relationship ◽  
Platelet Formation

Abstract The process of platelet formation by the fragmentation of megakaryocyte pseudopodia, termed proplatelets, demonstrable in the marrow sinusoids is poorly understood. “Stress” platelets produced under conditions of stimulated platelet production differ from normal circulating platelets with respect to volume and a number of functional characteristics. To clarify the relationship of stress platelets to proplatelets, rats were injected with heterologous platelet antiserum. Nondiscoid platelet forms, some characteristically beaded in appearance, strongly resembling bone marrow proplatelets, can be recovered in the circulation of normal rats. During the early period of recovery from acute thrombocytopenia, there was a substantial increase in the proportion of these elongated platelets in the citrated platelet rich plasma. Exposure to EDTA rendered them spherical. Circulating proplatelets may contribute significantly to the prompt increase in platelet volume during recovery from acute thrombocytopenia at a time prior to significant increase in megakaryocyte size and ploidy.

Technetium 99m Pyrophosphate Bone Imaging in the Evaluation of Trauma

1976 ◽  
Vol 1 (1) ◽  
pp. 18-25 ◽  
Author(s):  
KINICHI HISADA ◽  
YUTAKA SUZUKI ◽  
MATARO IIMORI
Keyword(s):  
Bone Imaging ◽  
Technetium 99M

Polaron formation dynamics in conducting polymers

2007 ◽  
Vol 157 (8-9) ◽  
pp. 380-385 ◽  
Author(s):  
Xiaojing Liu ◽  
Kun Gao ◽  
Yuan Li ◽  
Jiyong Fu ◽  
Jianhua Wei ◽  
...  
Keyword(s):  
Conducting Polymers ◽  
Formation Dynamics ◽  
Polaron Formation
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