Monoclonal Antibodies Against the Capsular Polysaccharides A, C, Y, W, and X of Neisseria meningitidis: A Platform for the Quality Control of Meningococcal Vaccines

2019 ◽  
pp. 181-203 ◽  
Author(s):  
Elizabeth González ◽  
Fátima Reyes ◽  
Oscar Otero ◽  
Frank Camacho ◽  
Maribel Cuello ◽  
...  
Keyword(s):  
Quality Control ◽  
Monoclonal Antibodies ◽  
Neisseria Meningitidis ◽  
Capsular Polysaccharides ◽  
Meningococcal Vaccines

Four monoclonal antibodies against capsular polysaccharides of Neisseria meningitidis serogroups A, C, Y and W135: Its application in identity tests

Biologicals ◽  
2013 ◽  
Vol 41 (4) ◽  
pp. 275-278 ◽  
Author(s):  
Fátima Reyes ◽  
Nevis Amin ◽  
Oscar Otero ◽  
Alicia Aguilar ◽  
Maribel Cuello ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Neisseria Meningitidis ◽  
Capsular Polysaccharides

scholarly journals Monoclonal antibody to serotype 17 of Neisseria meningitidis and their prevalence in Brazilian States

1995 ◽  
Vol 37 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Claudio Tavares Sacchi ◽  
Ana Paula Silva de Lemos ◽  
Maria Cecília Outeiro Gorla ◽  
Carl E. Frasch
Keyword(s):  
Monoclonal Antibody ◽  
Monoclonal Antibodies ◽  
Membrane Protein ◽  
Neisseria Meningitidis ◽  
Outer Membrane Protein ◽  
Meningococcal Disease ◽  
The Other ◽  
Capsular Polysaccharides ◽  
Gram Negative ◽  
The World

Neisseria meningitidis are gram-negative diplococci responsible for cases of meningococcal disease all over the world. The epidemic potential of N. meningitidis serogroup B and C is clearly a function of their serotype antigens more than of their capsular polysaccharides. Until recently, hiperimmune sera were used to detect typing antigens on the bacteria. The advent of monoclonal antibodies (MAbs) offered the opportunity to eliminate many of the cross-reactions and have improved the accuracy and reproducibility of meningococcal serotyping. We have produced a MAb to the outer membrane protein of the already existent serotype 17 that have been detected by the use of hiperimmune rabbit sera. The prevalence of this serotype epitope is low in the Brazilian strains. By using the MAb 17 we could not decrease the percentage of nontypeable serogroup C strains. However, there were a decreasing in nontypeable strains to 13% into serogroup B strains and to 25% into the other serogroups.

Capillary Electrophoresis for the Quality Control of Intact Therapeutic Monoclonal Antibodies

2017 ◽  
pp. 305-361 ◽  
Author(s):  
Anne-Lise Marie ◽  
Grégory Rouby ◽  
Emmanuel Jaccoulet ◽  
Claire Smadja ◽  
Nguyet Thuy Tran ◽  
...  
Keyword(s):  
Quality Control ◽  
Capillary Electrophoresis ◽  
Monoclonal Antibodies ◽  
Therapeutic Monoclonal Antibodies

scholarly journals Quality Control System for Beer Developed with Monoclonal Antibodies Specific to Barley Lipid Transfer Protein

Antibodies ◽  
2012 ◽  
Vol 1 (3) ◽  
pp. 259-272 ◽  
Author(s):  
Yukie Murakami-Yamaguchi ◽  
Junko Hirose ◽  
Kumiko Kizu ◽  
Fumiko Okazaki ◽  
Wataru Fujii ◽  
...  
Keyword(s):  
Quality Control ◽  
Monoclonal Antibodies ◽  
Control System ◽  
Lipid Transfer Protein ◽  
Quality Control System ◽  
Lipid Transfer ◽  
Transfer Protein

scholarly journals Assignment of Additional Anticapsular Antibody Concentrations to the Neisseria meningitidis Group A, C, Y, and W-135 Meningococcal Standard Reference Serum CDC1992

2002 ◽  
Vol 9 (3) ◽  
pp. 725-726 ◽  
Author(s):  
Cheryl M. Elie ◽  
Patricia K. Holder ◽  
Sandra Romero-Steiner ◽  
George M. Carlone
Keyword(s):  
Quality Control ◽  
Disease Control ◽  
Neisseria Meningitidis ◽  
Immunosorbent Assay ◽  
Immunoglobulin G ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control And Prevention ◽  
Group A ◽  
Reference Serum ◽  
Centers For Disease Control

ABSTRACT We assigned additional enzyme-linked immunosorbent assay antibody concentrations (immunoglobulin G [IgG], IgM, and IgA, and total) to the Neisseria meningitidis standard reference serum CDC1992 for groups Y and W-135 to 12 Centers for Disease Control and Prevention quality control sera. These assignments will supplement previous assignments and will aid in the evaluation of present and developing vaccines.

Sign in / Sign up

Export Citation Format

Share Document