Sphere-Forming Assays for Assessment of Benign and Malignant Pancreatic Stem Cells

2012 ◽  
pp. 281-290 ◽  
Author(s):  
Yue J. Wang ◽  
Jennifer M. Bailey ◽  
Meritxell Rovira ◽  
Steven D. Leach
Keyword(s):  
Stem Cells ◽  
Pancreatic Stem Cells

Islet Cell Therapy and Pancreatic Stem Cells

2013 ◽  
pp. 835-853 ◽  
Author(s):  
Juan Domínguez-Bendala ◽  
Antonello Pileggi ◽  
Camillo Ricordi
Keyword(s):  
Stem Cells ◽  
Cell Therapy ◽  
Islet Cell ◽  
Pancreatic Stem Cells

Islet Cell Therapy and Pancreatic Stem Cells

2011 ◽  
pp. 403-426
Author(s):  
Juan Domínguez-Bendala ◽  
Antonello Pileggi ◽  
Camillo Ricordi
Keyword(s):  
Stem Cells ◽  
Cell Therapy ◽  
Islet Cell ◽  
Pancreatic Stem Cells

scholarly journals Increased proliferation and altered cell cycle regulation in pancreatic stem cells derived from patients with congenital hyperinsulinism

PLoS ONE ◽  
2019 ◽  
Vol 14 (9) ◽  
pp. e0222350 ◽  
Author(s):  
Sophie G. Kellaway ◽  
Karolina Mosinska ◽  
Zainaba Mohamed ◽  
Alexander Ryan ◽  
Stephen Richardson ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Stem Cells ◽  
Cell Cycle Regulation ◽  
Congenital Hyperinsulinism ◽  
Pancreatic Stem Cells ◽  
Altered Cell ◽  
Cycle Regulation

scholarly journals Antidiabetic Effects of Bisamide Derivative of Dicarboxylic Acid in Metabolic Disorders

2020 ◽  
Vol 21 (3) ◽  
pp. 991 ◽  
Author(s):  
Angelina Vladimirovna Pakhomova ◽  
Vladimir Evgenievich Nebolsin ◽  
Olga Victorovna Pershina ◽  
Vyacheslav Andreevich Krupin ◽  
Lubov Alexandrovna Sandrikina ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Stem Cells ◽  
Dicarboxylic Acid ◽  
Metabolic Disorders ◽  
Biological Effects ◽  
Treatment Options ◽  
The Metabolic Syndrome ◽  
Pancreatic Stem Cells ◽  
The Impact

In clinical practice, the metabolic syndrome can lead to multiple complications, including diabetes. It remains unclear which component of the metabolic syndrome (obesity, inflammation, hyperglycemia, or insulin resistance) has the strongest inhibitory effect on stem cells involved in beta cell regeneration. This makes it challenging to develop effective treatment options for complications such as diabetes. In our study, experiments were performed on male C57BL/6 mice where metabolic disorders have been introduced experimentally by a combination of streptozotocin-treatment and a high-fat diet. We evaluated the biological effects of Bisamide Derivative of Dicarboxylic Acid (BDDA) and its impact on pancreatic stem cells in vivo. To assess the impact of BDDA, we applied a combination of histological and biochemical methods along with a cytometric analysis of stem cell and progenitor cell markers. We show that in mice with metabolic disorders, BDDA has a positive effect on lipid and glucose metabolism. The pancreatic restoration was associated with a decrease of the inhibitory effects of inflammation and obesity factors on pancreatic stem cells. Our data shows that BDDA increases the number of pancreatic stem cells. Thus, BDDA could be used as a new compound for treating complication of the metabolic syndrome such as diabetes.

Generation of islets of Langerhans from adult pancreatic stem cells

2002 ◽  
Vol 9 (6) ◽  
pp. 704-709 ◽  
Author(s):  
Ammon B. Peck ◽  
Janet G. Cornelius ◽  
Desmond Schatz ◽  
Vijayakumar K. Ramiya
Keyword(s):  
Stem Cells ◽  
Islets Of Langerhans ◽  
Pancreatic Stem Cells

Controlling α-SMA expression in adult human pancreatic stem cells by soluble factors

2009 ◽  
Vol 191 (1) ◽  
pp. 116-125 ◽  
Author(s):  
Anna Emilia Petschnik ◽  
Philipp Ciba ◽  
Charli Kruse ◽  
Sandra Danner
Keyword(s):  
Stem Cells ◽  
Soluble Factors ◽  
Adult Human ◽  
Pancreatic Stem Cells

Canonical Wnt signaling pathway contributes to the proliferation and survival in porcine pancreatic stem cells (PSCs)

2015 ◽  
Vol 362 (2) ◽  
pp. 379-388 ◽  
Author(s):  
Xin He ◽  
Wei Han ◽  
Shu-xian Hu ◽  
Ming-zhi Zhang ◽  
Jin-lian Hua ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wnt Signaling ◽  
Signaling Pathway ◽  
Wnt Signaling Pathway ◽  
Canonical Wnt Signaling ◽  
Pancreatic Stem Cells ◽  
Canonical Wnt
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