Colorectal Cancer: Management of Local Recurrence

The past few years have witnessed major developments in nanotechnology with great potential in powering new therapeutic tools for cancer management. Our goal in this study was to develop a biocompatible nanoshuttle for the efficient delivery of 5FU in colorectal cancer patients. Silk fibroin/Poly(ethylene glycol) nanoparticles (SF/PEG NPs) were obtained and further loaded with 5FU. These nanoshuttles were characterized in terms of morphological properties, size and size distribution, drug uptake and release potential as well as in vitro cytotoxicity potential screening. The SF/PEG + 5FU NPs cytotoxicity was determined on HT-29 cells after determination of the lethal dose 50 and targeted the evaluation of the cells viability, proliferation potential and migration and invasion potential. The inflammatory profile of RAW 264.7 macrophage cells was also determined by flow cytometry. The basic cytotoxicity screening revealed that the pristine SF/PEG NPs displayed good biocompatibility while the 5FU-loaded NPs induced cytotoxic effects on HT-29 cells. More, the 5FU-loaded SF/PEG NPs significantly reduced the migration and invasion processes as compared with the unloaded NPs. Lastly, we observed that the cytokine inflammatory profile was significantly altered after the treatment with the 5FU-loaded SF/PEG NPs as compared with the unloaded nanoshuttles.

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Management of colorectal cancer in the era of COVID-19: Challenges and suggestions

Science Progress ◽

10.1177/00368504211010626 ◽

2021 ◽

Vol 104 (2) ◽

pp. 003685042110106

Author(s):

Walid Alam ◽

Youssef Bouferraa ◽

Yolla Haibe ◽

Deborah Mukherji ◽

Ali Shamseddine

Keyword(s):

Colorectal Cancer ◽

Treatment Protocols ◽

Cancer Management ◽

Increased Risk ◽

Huge Impact ◽

Treatment Plans ◽

Virus Exposure ◽

Risk Of Exposure ◽

Colorectal Cancer Patients ◽

The Impact

The Coronavirus (COVID-19) pandemic had a huge impact on all sectors around the world. In particular, the healthcare system has been subject to an enormous pressure that has surpassed its ability in many instances. Additionally, the pandemic has called for a review of our daily medical practices, including our approach to colorectal cancer management where treatment puts patients at high risk of virus exposure. Given their higher median age, patients are at an increased risk for severe symptoms and complications in cases of infection, especially in the setting of immunosuppression. Therefore, a review of the routine colorectal cancer practices is needed to minimize risk of exposure. Oncologists should weigh risk of exposure versus the patient’s oncologic benefits when approaching management. In addition, treatment protocols should be modified to minimize hospital visits and admissions while maintaining the same treatment efficacy. In this review, we will focus on challenges that colorectal cancer patients face during the pandemic, while highlighting the priority in each case. We will also discuss the evidence for potential modifications to existing treatment plans that could reduce infectious exposure without compromising care. Finally, we will discuss the impact of the socio-economic difficulties faced by Lebanese patients due to a poor economy toppled by an unexpected pandemic.

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Anastomotic leakage: impact on local recurrence and survival in surgery of colorectal cancer

International Journal of Colorectal Disease ◽

10.1007/s003840050158 ◽

1998 ◽

Vol 13 (4) ◽

pp. 160 ◽

Cited By ~ 132

Author(s):

S. Petersen ◽

M. Freitag ◽

G. Hellmich ◽

K. Ludwig

Keyword(s):

Colorectal Cancer ◽

Local Recurrence ◽

Anastomotic Leakage

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The Role of Probiotics in Colorectal Cancer Management

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2020/3535982 ◽

2020 ◽

Vol 2020 ◽

pp. 1-17 ◽

Cited By ~ 7

Author(s):

Bhagavathi Sundaram Sivamaruthi ◽

Periyanaina Kesika ◽

Chaiyavat Chaiyasut

Keyword(s):

Colorectal Cancer ◽

Scientific Evidence ◽

Survival Rates ◽

Probiotic Supplementation ◽

Cancer Management ◽

Beneficial Impact ◽

Probiotic Intervention ◽

Probiotic Strains ◽

Unhealthy Diet ◽

Diet And Lifestyle

Colorectal cancer (CRC) is one of the most common cancerous diseases worldwide and causes leading cancer-associated deaths. Several factors are related to the incidence of CRC such as unhealthy diet and lifestyle, heredity, metabolic disorders, and genetic factors. Even though several advanced medical procedures are available for CRC treatment, the survival rates are poor with many adverse treatments associated side effects, which affects the quality of life. Probiotics are a well-known bioactive candidate for the treatment of several diseases and ill-health conditions. The recent scientific evidence suggested that probiotic supplementation protects the CRC patients from treatment-associated adverse effects. The manuscript summarizes the influence of probiotic supplementation on the health status of CRC patients and discusses the possible mechanism behind the protective effect of probiotics against CRC. The literature survey revealed that beneficial impact of probiotic supplementation depends on several factors such as strain, dosage, duration of the intervention, host physiology, and other food supplements. The probiotic intervention improves the microbiota, releases antimicrobials and anticarcinogenic agents, helps to remove carcinogens, and improves the intestinal permeability, tight junction function, and enzyme activity in CRC patients. Besides, not all probiotic strains exhibit anti-CRC activities; it is necessary to screen the potent strain for the development of a probiotic-based therapeutic agent to control or prevent the incidence of CRC.

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Adjuvant Value of Turmeric Extract (Containing Curcumin) in Colorectal Cancer Management

Natural Products for Cancer Chemoprevention ◽

10.1007/978-3-030-39855-2_7 ◽

2020 ◽

pp. 209-239

Author(s):

Clara Bik-San Lau ◽

Grace Gar-Lee Yue

Keyword(s):

Colorectal Cancer ◽

Cancer Management ◽

Turmeric Extract

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Risk factors in the recurrence of the colorectal cancer

Acta chirurgica iugoslavica ◽

10.2298/aci0202040u ◽

2002 ◽

Vol 49 (2) ◽

pp. 40-43 ◽

Cited By ~ 1

Author(s):

J. Ulanska ◽

A. Dziki ◽

W. Langner

Keyword(s):

Colorectal Cancer ◽

Risk Factors ◽

Rectal Cancer ◽

Local Recurrence ◽

Early Stage ◽

Concomitant Treatment ◽

Preventive Chemotherapy ◽

Tnm System ◽

Definition Of ◽

Colorectal Cancer Patients

Traditionally, the clinical outcome of colorectal cancer patients may be predicted by pathological staging by either Dukes staging or the UICC-TNM system. However, some of Dukes stage A (approximately 10% of patients) and Dukes B patients (30-40%) will develop local recurrence or distant metastasis years after receiving standard surgical treatments. Therefore it is important to find some other indicators that can predict for recurrence so that we can screen for high-risk early-stage patients who may need preventive chemotherapy or other adjuvant therapy. The aim of this study is determination of risk factor for local recurrence in rectal cancer. In this study there has been used and summarized also research records and publications from different clinical hospitals according to actual international literature. Part of elements connected with patient, tumor and genetic and immunological factors remains independent on curative procedures. However better investigation these factors might affect on therapy, frequency of follow-up examinations, and help to detect recurrence at very early phase. Concomitant treatment factors are able to be moderate by surgeons and therapeutics. Therefore precise definition of risk factors might be helpful in decrease recurrence rate in patients with rectal cancer.

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