Development of a New Formulation for Onychomycosis Treatment Using Furvina® as an Active Pharmaceutical Ingredient

2018 ◽  
pp. 191-203
Author(s):  
Zenia Perez-Rodriguez ◽  
Yaset Rodríguez-Rodríguez ◽  
Zenaida Rodriguez-Negrin ◽  
Reinaldo Molina-Ruiz ◽  
Ricardo Medina-Marrero ◽  
...  
Keyword(s):  
Active Pharmaceutical Ingredient ◽  
New Formulation

scholarly journals Evaluation of Physical-Chemical and Microbiological Stability of Fluconazole Oral Suspensions for Hospital Use

2020 ◽  
Vol 4 (1) ◽  
pp. 39-43
Author(s):  
Camilo Marques D'Amore ◽  
Elisa De Saldanha Simon ◽  
Martin Steppe
Keyword(s):  
Analytical Method ◽  
High Performance ◽  
Active Pharmaceutical Ingredient ◽  
Oral Formulation ◽  
Porto Alegre ◽  
Pet Bottles ◽  
Physical Chemical ◽  
Oral Liquid ◽  
Microbiological Stability ◽  
New Formulation

Fluconazole is an important drug in the treatment of cutaneous and systemic mycoses. The Hospital de Clínicas de Porto Alegre performs a derivation of fluconazole capsules to obtain an oral liquid formulation that is easily administered and whose dose can be adjusted. In order to replace the derivation for a formulation produced from an active pharmaceutical ingredient, this study sought to develop a liquid oral formulation, evaluate its physical chemical and microbiological stability and demonstrate suitability of the analytical method for the formulation assay. Seven different formulations of pharmaceutical suspension form were produced and evaluated for pH, viscosity, sedimentation volume and assay. The analytical method by High Performance Liquid Chromatography was demonstrated. Two most promising formulations were manipulated in the Farmácia Semi-Industrial do Hospital de Clínicas de Porto Alegre and stored in amber PET bottles under three different conditions: room temperature, under refrigeration (2 to 8 ºC) and in an oven (40 ° C). Samples were collected after 0, 7 and 14 days to evaluate physical-chemical stability, assay, pH and macroscopic aspects. Samples were collected after 0 and 21 days to evaluate microbiological stability. It was possible to demonstrate stability for one of the formulations for a 14-day period. Throughout the study, the chosen formulation presented adequate quantification of fluconazole, constant pH, no organoleptic changes and no microbial growth. The results suggest the incorporation of a new formulation for fluconazole to the Farmacia Semi-Industrial portfolio).

scholarly journals Nanocrystalization: An Emerging Technology to Enhance the Bioavailability of Poorly Soluble Drugs

2019 ◽  
Vol 7 (4) ◽  
pp. 259-278 ◽  
Author(s):  
Kavita Joshi ◽  
Akhilesh Chandra ◽  
Keerti Jain ◽  
Sushama Talegaonkar
Keyword(s):  
Water Solubility ◽  
Drug Loading ◽  
Chemical Properties ◽  
Active Pharmaceutical Ingredient ◽  
Pharmaceutical Product ◽  
Drug Formulation ◽  
Water Soluble ◽  
Drug Candidate ◽  
Formulation Development ◽  
New Formulation

Most of the active pharmaceutical ingredient used in the management of disease have poor water solubility and offer grueling problems in drug formulation development since low solubility is generally associated with poor dissolution characteristics which leads to poor oral bioavailability. The great challenge for the development of a pharmaceutical product is to create its new formulation and drug delivery system to limit solubility problems of existing drug candidate. Limited drug-loading capacity requires a large amount of carrier material to get appropriate encapsulation of the drug, which is another major challenge in the development of pharmaceutical product which could be resolved by developing nanocrystals (NCs). A significant research in the past few years has been done to develop NCs which helps in the delivery of poorly water soluble drugs via different routes. The technology could continue to thrive as a useful tool in pharmaceutical sciences for the improvement of drug solubility, absorption and bioavailability. Many crystalline compounds have pulled in incredible consideration much of the time, due to their ability to show good physical and chemical properties when contrasted with their amorphous counterparts. Nanocrystals have been proven to show atypical properties compared to the bulk. This review article explores the principles of the important nanocrystallization techniques including NCs characterization and its application.

Adult’s Total Parenteral Nutrition: Initiative and Implementation of Standardized Formulation in Saudi Arabia

2018 ◽  
Vol 4 (3) ◽  
pp. 483-487
Author(s):  
Yousef Ahmed Alomi ◽  
Hussam Saad Almalki ◽  
Aisha Omar Fallatah ◽  
Awatif Faraj Alshammari ◽  
Nahedh Rashed Alotaibi
Keyword(s):  
Saudi Arabia ◽  
Parenteral Nutrition ◽  
Pharmacy Practice ◽  
International Standards ◽  
Kingdom Of Saudi Arabia ◽  
Parental Nutrition ◽  
International Regulations ◽  
One Year ◽  
New Formulation ◽  
New System

The general administration of pharmaceutical care started potential pharmacy practice program. The program is part of accreditation professional’s process of national and international regulations. The adult’s parenteral nutrition was one of the critical programs. The most healthcare professionals are not familiar with the new system. The new initiatives system adult’s standardized concentration formulation of total parental nutrition as complementary to the previous one. The new formulation consisted of all parental nutrition requirements based on national and international standards. The new system can be converted as computerized physician orders. The new initiatives may implement as project management model over one year or less than that’s. The new system prevents nutrition-related problems, and medication errors, and improve clinical outcomes of the adults’ population in the Kingdom of Saudi Arabia.

L'esperienza clinica con Levometadone nel trattamento del disturbo da uso di oppiacei

MISSION ◽  
2019 ◽  
pp. 54-57
Author(s):  
Marco Riglietta ◽  
Paolo Donadoni ◽  
Grazia Carbone ◽  
Caterina Pisoni ◽  
Franca Colombi ◽  
...  
Keyword(s):  
Adverse Events ◽  
Real Life ◽  
Opioid Use Disorder ◽  
Racemic Mixture ◽  
Opioid Use ◽  
The Real ◽  
New Formulation

In Italy, at the end of the 1970s, methadone hydrochloride was introduced for the treatment of opioid use disorder, in the form of a racemic mixture consisting of levomethadone and dextromethadone.In 2015 Levometadone was introduced, a new formulation marketed in Italy for the treatment of opioid use disorder in 2015.The article aims to bring the experience of an Italian Addiction Centre back to the use of this new formulation in the "real life" analyzing the efficacy, the trend of adverse events and pharmacological iterations in a context in which the treated population often uses besides the opiates, cocaine and alcohol, are burdened by a relevant physical and psychic comorbidity and frequently have a prescribed polypharmacy.

TRADISI AKADEMIK DALAM KHALAQAH TAFSI>R (Orientasi Semantik al-Qur’an Klasik alam Diskursus Hermeneutik)

2016 ◽  
Vol 1 (1) ◽  
pp. 93
Author(s):  
Syamsul Wathani
Keyword(s):  
New Formulation

This article discusses Qur’anic semantic within hermeneutic discourse. The classical interpretation of the Qur’an (I-IV H) are set to be the sobject matter to be discussed within the framework of hermeneutic. By doing so, the article is expected to contribute to give a new formulation about the classical interpretation discourse on the Qur’an. Besides, the article is also expected to discover the new theory about Qur’anic hermeneutic which operated in the sphere of text. The classical Qur’anic semantic has shown the contestation which not only dit it appear in the sphere of meaning (dilalah), but more deeply in played a dialecticsof language between oral notion (al-Qur’an/kalam) and the recipient (khitab al-Qur’an).

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