Warpage is one of the most common defects of a plastic product in the polymer injection molding process. It is attributed to the differential shrinkage after the part is ejected from the die cavity due to the nonlinear material property of the polymer, improper design of the cooling system, geometry of the part and the related process parameters. In this paper, the warpage formation of a plastic part, Step Pad of polypropylene copolymer, in the cooling stage of the polymer injection molding process was simulated by finite element analysis (FEA). A three-dimensional FEA model, taking into account the nonlinear material (polypropylene copolymer) properties, with a thermal-structural sequential coupled approach of higher computing efficiency was developed. The effects of mold closed time and layout of cooling system on the dimension and shape of the part were investigated. Industrial experiments for the different mold closed times (25s, 30s, 35s, 40s, 45s, 50s, and 55s) were conducted. The simulation results were compared with the experimental results. The approach is effective in predicting warpage in the polymer injection molding processes.