Medically Compromised Patients: A Biological and Social Challenge

2019 ◽  
pp. 11-20
Author(s):  
Lin Xiang ◽  
Ya-qian Chen ◽  
Quan Yuan
Keyword(s):  
Social Challenge ◽  
Compromised Patients

Threatening Conditions and Challenges in the Modern Living of the Old People in Republic of Macedonia

2016 ◽  
Vol 2 (2) ◽  
pp. 110
Author(s):  
Hava Rexhep
Keyword(s):  
Kidney Diseases ◽  
Methodological Approach ◽  
Research Problem ◽  
Functional Dependency ◽  
Old People ◽  
Stomach Diseases ◽  
Social Challenge ◽  
The Social ◽  
Build System

The aging is not only a personal but also a social challenge from several aspects, several dimensions; a challenge aiming to build system approaches and solutions with a long term importance. Aims: the main aim of this research is to investigate the conditions and challenges in the modern living of the old people, primarily in terms of the social care. However, this research is concentrated on a big group of the population and their challenges are the most intensive in the modern living. The investigation of the conditions and challenges in the aging are basis and encouragement in realizing the progressive approaches in order to improve the modern living of the old people. The practical aim of the research is a deep investigation and finding important data, analyzing the basic indicators of the conditions, needs and challenges in order to facilitate the old population to get ready for the new life. Methods and techniques: Taking into consideration the complexity of the research problem, the basic methodological approach is performed dominantly by descriptive-analytical method. The basic instrument for getting data in the research is the questionnaire with leading interview for the old people. Results: The research showed that the old people over 70-79 years old in a bigger percentage manifested difficulties primarily related to the functional dependency, respectively 39,33 % of the participants in this category showed concern about some specific functional dependency from the offered categories. The percentage of the stomach diseases with 38,33 % is important, as well as the kidney diseases with 32,83% related to the total population and the category of the old people over 80. Conclusion: The old people very often accept the life as it is, often finding things fulfilled with tolerance and satisfaction. However the health problems of the old people are characterized with a dominant representation. The chronic diseases and the diseases characteristic for the aging are challenge in organizing adequate protection which addresses to taking appropriate regulations, programs and activities.

Gingerol Derivatives as 14α-demethylase Inhibitors: Design and Development of Natural, Safe Antifungals for Immune-compromised Patients

2020 ◽  
Vol 17 (7) ◽  
pp. 918-928
Author(s):  
Sweta Sharma ◽  
Arpita Yadav
Keyword(s):  
Cell Membranes ◽  
Fungal Infections ◽  
Dynamics Simulation ◽  
Stable Complex ◽  
Active Site Residues ◽  
Design And Development ◽  
Triazole Derivative ◽  
Fungal Cell ◽  
Term Administration ◽  
Compromised Patients

Background: : Currently, clinically used drugs for internal fungal infections have severe side effects. Patients suffering from severe fungal infections and those at a constant risk of developing such infections require long-term administration of safe antifungals. Objective: : This work deals with the design and development of safe, non-toxic antifungals derived from natural compounds for immune-compromised patients, such as HIV patients, who are at a constant risk of developing internal fungal infections. Methods: : Molecular modeling, docking and molecular dynamics simulation studies were performed on the main constituents of ginger and their derivatives to study their capability to inhibit 14α- demethylase enzyme. Results: : Ergosterol is the key component of the fungal cell membrane for its integrity and rigidity, synthesized from lanosterol catalyzed by 14α-demethylase enzyme. In our studies, it is determined that 6-gingerol, 6-paradol, 6-shogaol and their imidazole and triazole derivatives can inhibit the synthesis of ergosterol thus weakening the fungal cell membranes. The triazole derivative of 6-gingerol forms enhanced binding interactions with the active site residues of 14α-demethylase, carries an affinity for catalytically required cofactor heme and forms a stable complex with time without the probability of premature expulsion. Thus, this compound inhibits the formation of ergosterol leading to weakened fungal cell membranes and eventually death of fungal cells. Conclusion: : The triazole derivative of 6-gingerol is recommended as a lead compound for the development of non-toxic antifungals.

Goal energy intake for medically compromised patients with eating disorders: A systematic review

2021 ◽  
Vol 78 (1) ◽  
pp. 86-100 ◽  
Author(s):  
Hei Man Chan ◽  
Jane Liliana Jaffe ◽  
Natasha Jane D'Souza ◽  
Joshua Rhys Lowe ◽  
Kylie Matthews‐Rensch
Keyword(s):  
Systematic Review ◽  
Eating Disorders ◽  
Energy Intake ◽  
Compromised Patients

scholarly journals Assessment of Poverty by Municipalities in the Context of Population Ageing—The Case of Małopolskie Voivodeship

2021 ◽  
Vol 13 (5) ◽  
pp. 2563
Author(s):  
Małgorzata Ćwiek ◽  
Katarzyna Maj-Waśniowska ◽  
Katarzyna Stabryła-Chudzio
Keyword(s):  
The Elderly ◽  
Research Problem ◽  
Point Of View ◽  
Computer Assisted ◽  
Chi Square ◽  
Social Challenge ◽  
Depth Analysis ◽  
Qualitative Variables ◽  
Chi Square Test ◽  
Research Gap

This article undertakes the research problem of the assessment of the significance of poverty as a social challenge for local self-government units, and the differences in the assessment of the incidence of this phenomenon depending on the type of municipality. The authors also analyse the relationships between the ageing of the population and the assessment of the extent of poverty by municipalities. It must be pointed out that the undertaken problem has not been a subject of in-depth analysis thus far. Hence, this article fills the identified research gap in this field. The empirical part is based on the results of our own research, conducted using the Computer-Assisted Web Interview (CAWI) method on a sample of 144 municipalities of the Małopolskie Voivodship (Poland). In order to verify whether there is a relationship between the researched qualitative variables, the chi-square test of independence was used. In order to determine the relationships occurring between the categories of variables characterising the scale of the incidence of poverty and the remaining variables, a correspondence analysis was conducted. The research enabled us to find the issue of poverty to be one of the most important social problems from the point of view of municipalities. It is also worth noting that the degree of ageing in the population has an impact on the assessment of poverty among the elderly.

Missing Girls or Hidden Girls? A Comment on Shi and Kennedy's “Delayed Registration and Identifying the ‘Missing Girls’ in China”

2017 ◽  
Vol 231 ◽  
pp. 797-803 ◽  
Author(s):  
Yong Cai
Keyword(s):  
Political System ◽  
Census Data ◽  
Numerical Estimate ◽  
Short Note ◽  
Foreseeable Future ◽  
Birth Cohorts ◽  
Data Manipulation ◽  
Social Challenge ◽  
Education Statistics ◽  
Lines Of Evidence

In a recent article published in this journal, Yaojiang Shi and John Kennedy suggest that China's missing girls problem is much more a statistical artefact than previously known. According to their analysis, unreported female births, or hidden girls, account for 73 per cent of the 15 million missing girls from the 1990–2010 birth cohorts in the 2010 census. Their conclusion is based in part on their fieldwork, but the numerical estimate is grounded on their understanding and analyses of Chinese census data. While the insights from their fieldwork – that China's political system leaves ample room for data manipulation and delayed registration – cannot be faulted, Shi and Kennedy's analyses of Chinese census data are questionable and their conclusion is in contradiction with the “missing girls” shown in other data sources. In this short note, I present three lines of evidence to challenge Shi and Kennedy's conclusion: one from the censuses, one from official education statistics, and one from survey data. For the sake of clarity, I use two terms to describe missing girls: nominal missing – the number of missing girls as revealed by population statistics, and truly missing – the number of missing girls excluding those hidden (unreported) girls. My conclusion backs the conventional wisdom about the missing girls phenomenon in China: the elevated sex ratios in Chinese population, or “missing girls,” is not a statistical artefact, but a real social challenge that China has to face for now and for the foreseeable future.

The Problem of Christian Unity in Early Nineteenth-Century America

1963 ◽  
Vol 32 (1) ◽  
pp. 3-16 ◽  
Author(s):  
Lefferts A. Loetscher
Keyword(s):  
Nineteenth Century ◽  
American Revolution ◽  
Early Nineteenth Century ◽  
Nineteenth Century America ◽  
Social Challenge ◽  
Atlantic Community ◽  
Christian Unity ◽  
Aggressive Attack

American Protestants in the early nineteenth century faced intellectual and social challenge which made conspicuous the weakness of their own divided condition. The American Revolution—which was part of a larger upheaval in the Atlantic Community—had spread Enlightenment ideas, with their aggressive attack on orthodoxy. Quite typical was the lament of a convention of Massachusetts Congregational ministers in 1799 over “the present decay of Christian morals and piety, and the awful prevalence of speculative and practical infidelity.” Well before the middle eighteen-thirties the tide of deism had ebbed, but some, like the editors of the new Christian Review, were still building sea walls against it.

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