Using Stem Cells and Synthetic Scaffolds to Model Ethically Sensitive Human Placental Tissue

2021 ◽  
pp. 219-234
Author(s):  
Georgia R. Kafer
Keyword(s):  
Stem Cells ◽  
Placental Tissue ◽  
Synthetic Scaffolds ◽  
Human Placental Tissue

A Preliminary Study on Human Placental Tissue Impaired by Gestational Diabetes: A Comparison of Gel-Based versus Gel-Free Proteomics Approaches

2016 ◽  
Vol 22 (2) ◽  
pp. 71-82 ◽  
Author(s):  
Marco Roverso ◽  
Maura Brioschi ◽  
Cristina Banfi ◽  
Silvia Visentin ◽  
Silvia Burlina ◽  
...  
Keyword(s):  
Gestational Diabetes ◽  
Placental Tissue ◽  
Human Placental Tissue ◽  
Preliminary Study

scholarly journals Seasonally Variant Gene Expression in Full-Term Human Placenta

2020 ◽  
Author(s):  
Danielle A. Clarkson-Townsend ◽  
Elizabeth Kennedy ◽  
Todd M. Everson ◽  
Maya A. Deyssenroth ◽  
Amber A. Burt ◽  
...  
Keyword(s):  
Health Outcomes ◽  
Placental Tissue ◽  
Later Life ◽  
Full Term ◽  
Season Of Birth ◽  
Rhythmic Expression ◽  
Health And Development ◽  
Human Placental Tissue ◽  
Variant Genes ◽  
Ribosomal Activity

ABSTRACTSeasonal exposures influence human health and development. The placenta, as a mediator of the maternal and fetal systems and a regulator of development, is an ideal tissue to understand the biological pathways underlying relationships between season of birth and later life health outcomes. Here, we conducted a transcriptome-wide association study of season of birth in full-term human placental tissue to evaluate whether the placenta may be influenced by seasonal cues. Of the analyzed transcripts, 583 displayed differential expression between summer and winter births (FDR q<0.05); among these, BHLHE40, MIR210HG, and HILPDA had increased expression among winter births (Bonferroni p<0.05). Enrichment analyses of the seasonally variant genes between summer and winter births indicated over-representation of transcription factors HIF1A, VDR, and CLOCK, among others, and of GO term pathways related to ribosomal activity and infection. Additionally, a cosinor analysis found rhythmic expression for approximately 11.9% of all 17,664 analyzed placental transcripts. These results suggest that the placenta responds to seasonal cues and add to the growing body of evidence that the placenta acts as a peripheral clock, which may provide a molecular explanation for the extensive associations between season of birth and health outcomes.

The specific 3H-ouabain binding to Na+/K+-ATPase of the human placental tissue is inhibited by newborn plasma extracts

Steroids ◽  
1988 ◽  
Vol 52 (4) ◽  
pp. 363-364
Author(s):  
Anna Paci ◽  
Silvana Balzan ◽  
Franca Cocci ◽  
Hans Peter Niedermeyer ◽  
Aldo Clerico
Keyword(s):  
Placental Tissue ◽  
Ouabain Binding ◽  
Human Placental Tissue

From naive iPS cells toward human placental tissue via trophectoderm

Placenta ◽  
2021 ◽  
Vol 114 ◽  
pp. 151-152
Author(s):  
Shingo Io ◽  
Eiji Kondoh ◽  
Yasuhiro Takashima ◽  
Masaki Mandai
Keyword(s):  
Placental Tissue ◽  
Ips Cells ◽  
Human Placental Tissue

Placental Tissue Stem Cells and their role in Neonatal Diseases

2021 ◽  
pp. 101322
Author(s):  
Andreas Damianos ◽  
Kui Xu ◽  
Gregory T. Kalin ◽  
Vladimir V. Kalinichenko
Keyword(s):  
Stem Cells ◽  
Placental Tissue

scholarly journals Course of placental 11beta-hydroxysteroid dehydrogenase type 2 and 15-hydroxyprostaglandin dehydrogenase mRNA expression during human gestation

2001 ◽  
pp. 187-192 ◽  
Author(s):  
E Schoof ◽  
M Girstl ◽  
W Frobenius ◽  
M Kirschbaum ◽  
R Repp ◽  
...  
Keyword(s):  
Gene Expression ◽  
Mrna Expression ◽  
Placental Tissue ◽  
Hydroxysteroid Dehydrogenase ◽  
Normal Pregnancy ◽  
Premature Babies ◽  
Gene Level ◽  
Human Placental Tissue ◽  
Human Placental Cells

BACKGROUND: During human pregnancy, 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) plays an important role in protecting the fetus from high maternal glucocorticoid concentrations by converting cortisol to inactive cortisone. Furthermore, 11beta-HSD2 is indirectly involved in the regulation of the prostaglandin inactivating enzyme 15-hydroxyprostaglandin dehydrogenase (PGDH), because cortisol reduces the gene expression and enzyme activity of PGDH in human placental cells. OBJECTIVE: To examine developmental changes in placental 11beta-HSD2 and PGDH gene expression during the 2nd and 3rd trimesters of human pregnancies. METHODS: In placental tissue taken from 20 healthy women with normal pregnancy and 20 placentas of 17 mothers giving birth to premature babies, 11beta-HSD2 and PGDH mRNA expression was determined using quantitative real-time PCR. RESULTS: Placental mRNA expression of 11beta-HSD2 and PGDH increased significantly with gestational age (r=0.55, P=0.0002 and r=0.42, P=0.007). In addition, there was a significant correlation between the two enzymes (r=0.58, P<0.0001). CONCLUSIONS: In the course of pregnancy there is an increase in 11beta-HSD2 and PGDH mRNA expression in human placental tissue. This adaptation of 11beta-HSD2 prevents increasing maternal cortisol concentrations from transplacental passage and is exerted at the gene level. 11beta-HSD2 up-regulation may also lead to an increase in PGDH mRNA concentrations that, until term, possibly delays myometrial contractions induced by prostaglandins.

The relationship between human β-defensin 3 (hBD3) expression and mean histamine concentration in human placental tissue

2008 ◽  
Vol 57 (S1) ◽  
pp. 69-70 ◽  
Author(s):  
D. Szukiewicz ◽  
J. Klimkiewicz ◽  
M. Pyzlak ◽  
A. Szukiewicz ◽  
D. Maslinska
Keyword(s):  
Placental Tissue ◽  
Histamine Concentration ◽  
Human Placental Tissue ◽  
The Relationship

Ascorbic acid inhibition of aromatase activity in human placental tissue

1981 ◽  
Vol 14 (2) ◽  
pp. 185-193 ◽  
Author(s):  
Leon Milewich ◽  
Grace T. Chen ◽  
Paul C. MacDonald ◽  
Julian A. Peterson
Keyword(s):  
Ascorbic Acid ◽  
Placental Tissue ◽  
Acid Inhibition ◽  
Aromatase Activity ◽  
Human Placental Tissue
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