scholarly journals FORMULATION AND IN VITRO–IN VIVO PHARMACOKINETIC EVALUATION OF CARDIOVASCULAR DRUG-LOADED PULSATILE DRUG DELIVERY SYSTEMS

2021 ◽  
pp. 144-151
Author(s):  
KUMAR BABU PASUPULETI ◽  
VENKATACHALAM A. ◽  
BHASKAR REDDY KESAVAN
Keyword(s):  
Drug Release ◽  
Ethyl Cellulose ◽  
Release Kinetic ◽  
In Vitro Drug Release ◽  
The Core ◽  
Coated Tablet ◽  
Tablet Formulations ◽  
Core Tablet

Objective: This study is to formulate Nebivolol into a Pulsatile liquid, solid composite compression coated tablet, which will delay the release of the drug in early morning hypertension conditions. Methods: The liquid, solid composite tablet was formulated and compressed with the ethylcellulose coating polymer. The percent in vitro drug release of the liquid solid composite compressed tablet was tested. Based on disintegration time and wetting time, the LCS2, LCS3, LSC6, LCS7 and LCS12 formulations were found to be the optimized solid-liquid compacts fast-dissolving core tablet formulations, which may be excellent candidates for further coating with polymer to transfer into press coated pulsatile tablet formulations. Coating the core tablet with varying ethyl cellulose concentrations resulted in five different formulations of the pulsatile press-coated tablet (CT1, CT2, CT3, CT4, CT5). In vitro drug release, in vitro release, kinetic studies, in vivo pharmacokinetic and stability tests were all performed for the prepared pulsatile press coated tablet. Results: CT3 tablets are coated with ethyl cellulose polymer, which shows maximum controlled drug release from the core tablet i.e. 96.34±1.2% at 8th h. It shows there was an efficient delay in drug release form core tablet i.e. up to 3 h, followed by the maximum amount of drug release of 96.34±2.4 at 8h. Which shows the core drug will be more efficiently protected from the gastric acid environment 1.2 pH, duodenal environment 4.0 pH and release drug only in the small intestine. Conclusion: According to the findings, CT3 Pulsatile press-coated tablet increased the bioavailability of Nebivolol by 3.11 percent.

scholarly journals Analisis Penyebab dan Solusi Rekonsiliasi Finished Goods Menggunakan Hipotesis Statistik dengan Metode Pengujian Independent Sample T-Test di PT.Merck, Tbk.

Jurnal Tekno ◽  
2019 ◽  
Vol 16 (2) ◽  
pp. 35-48
Author(s):  
Riana Magdalena ◽  
Maria Angela Krisanti
Keyword(s):  
T Test ◽  
Over The Counter ◽  
Coated Tablet ◽  
Core Tablet

Merck, Tbk. merupakan perusahaan manufaktur yang bergerak di bidang pembuatan obat dengan memproduksi obat yang dituju untuk pasar over-the-counter (OTC) seperti Sangobion dan Neurobion dan juga pasar obat resep untuk rumah sakit. Berdasarkan Packaging Work Sheet (PWS) dari produk “X” yang diproduksi di PT. Merck, Tbk. ditemukan rekonsiliasi pada finished goods yang melebihi spesifikasi yang telah ditentukan sebelumnya oleh perusahaan. Rekonsiliasi merupakan perbedaan antara jumlah material yang masuk dengan material yang keluar sehingga jika rekonsiliasi melebihi yang seharusnya maka PT. Merck, Tbk. dapat mengalami kerugian karena jumlah material yang jadi tidak sesuai dengan material yang diproduksi. Berdasarkan permasalahan yang terjadi, maka penulis melakukan pengolahan data menggunakan hipotesis statistik dengan menggunakan metode pengujian Independent Sample T-Test untuk mengetahui proses produksi apa yang berpotensi menyebabkan rekonsiliasi pada finished goods produk “X”. Dengan diketahuinya penyebab dari rekonsiliasi maka dapat dicari solusi yang tepat untuk mengatasi rekonsiliasi tersebut. Dari pengolahan data yang dilakukan, ditemukan bahwa terdapat perbedaan secara nyata antara berat rata-rata core tablet dengan berat coated tablet yang menandakan bahwa proses sugar coating berpengaruh secara signifikan terhadap variasi berat yang berpotensi menyebabkan rekonsiliasi. Oleh karena itu, ditentukan solusi yang tepat untuk memperbaiki proses tersebut.

Feasibility of Assam Bora Rice Starch as a Compression Coat of 5-Fluorouracil Core Tablet for Colorectal Cancer

2012 ◽  
Vol 9 (1) ◽  
pp. 105-110 ◽  
Author(s):  
Mohammad Zaki Ahmad ◽  
Sohail Akhter ◽  
Mohammad Anwar ◽  
Anjali Singh ◽  
Iqbal Ahmad ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Rice Starch ◽  
Core Tablet

scholarly journals Design and In Vitro Evaluation of Chrono Modulated Theophylline Tablets

1970 ◽  
Vol 1 (1) ◽  
pp. 25-28
Author(s):  
B Vijaya Kumar ◽  
B Nagaraj ◽  
B Agaiah ◽  
D Rambhau
Keyword(s):  
Drug Delivery ◽  
Key Words ◽  
Delivery System ◽  
Research Work ◽  
Lag Phase ◽  
Enteric Polymer ◽  
Key Words Theophylline ◽  
Model Drug ◽  
Core Tablet

The objective of this research work was to prepare a chrono modulated delivery system to meet chronopharmacological needs of asthma. In this study theophylline was selected as a model drug. To meet this objective we considered an initial lag phase of release for 3-5 hrs and later a rapid (surge) release phase. To achieve surge release a rapidly releasing core tablet of theophylline was developed by admixing theophylline with effervescent granules and super disintegrants. The lag phase in release was achieved by coating the EV core tablets with release retarding polymer EUDRAGIT RS-100 containing HPMC, further over coated with enteric polymer CAP. The results indicate that a rapidly releasing EV tablet of theophylline cab be developed which when coated with the polymers a lag phase of 2 hrs was achievable followed by a surge release. Key Words: Theophylline, Chrono Modulated Drug Delivery, Asthma. doi:10.3329/sjps.v1i1.1782 S. J. Pharm. Sci. 1(1&2): 25-28

scholarly journals FORMULATION AND EVALUATION OF PRESS COATED TABLETS OF LANSOPRAZOLE

2019 ◽  
pp. 49-56
Author(s):  
Prasanthi D ◽  
PRASHANTI. S ◽  
MEGHANA G
Keyword(s):  
Ethyl Cellulose ◽  
Chemical Properties ◽  
Enteric Coating ◽  
Scanning Calorimetry ◽  
Dsc Studies ◽  
Delayed Release ◽  
Ich Guidelines ◽  
Physico Chemical ◽  
Enteric Coated ◽  
Core Tablet

Objective: Lansoprazole an proton pump inhibitor, degrades in acidic environment, hence protection of drug is done by coating the drug with enteric coating polymers. The aim and objective of the present study was to prepare enteric coated delayed release tablets of lansoprazole by using press coating technique. Methods: Core tablets were prepared by direct compression and evaluated for their physico-chemical properties. Press coated tablets were formulated by using different combinations of ethyl cellulose, HPMC E15 and HPMC K4M as a coating layer. Core and coated tablets were optimized by dissolution studies. Fourier transform infra-red spectroscopy (FTIR) and differential scanning calorimetry (DSC) studies were performed to know the compatibility of drug with various excipients. Surface morphology and uniformity of coat was evaluated by Scanning electron microscopy (SEM). Stability of optimized formulation was evaluated according to ICH guidelines. Results: Among the various formulations F5 containing ethyl cellulose: HPMC E15 (10:90) and F9 containing ethyl cellulose: HPMC K4M (25:75) were optimized based on the better drug release within 8 h. DSC studies and FTIR studies revealed compatibility of drug with excipients. Obtained SEM photographs of tablets showed that the surface of core tablet is uniformly coated with coat by press coating. Stability studies showed that the formulations were stable. Conclusion: As a result, delayed release press coated tablets developed in this study delivered lansoprazole in the intestine and protected the drug from degradation.

scholarly journals Development and evaluation of a chronotherapeutic drug delivery system of torsemide

2011 ◽  
Vol 47 (3) ◽  
pp. 593-600 ◽  
Author(s):  
Songa Ambedkar Sunil ◽  
Nali Sreenivasa Rao ◽  
Meka Venkata Srikanth ◽  
Michael Uwumagbe Uhumwangho ◽  
Kommana Srinivas Phani Kumar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Lag Time ◽  
Delivery Systems ◽  
Burst Release ◽  
Treatment Of Hypertension ◽  
Drug Polymer Interaction ◽  
Compression Coating ◽  
Core Tablet ◽  
Polymer Interaction

The objective of this study was to prepare and evaluate chronotherapeutic drug delivery systems (ChrDDs) of torsemide. Compression coated tablets (CCT) containing torsemide in the core tablet were prepared by the compression coating technique with different grades of polyethylene oxide (PEO WSR 301 & 1105). The optimized formulations were characterised for tabletting parameters and drug polymer interaction by Fourier-Transform Infrared Spectroscopy (FTIR).The hardness of all the CCT using PEO WSR 301 & PEO WSR 1105 were in the range 6-8 kg/cm² & 5.5 to 7 kg/cm² respectively. Their friability values were <0.3%. All the CCT showed a clear lag time but finalized as per the predetermined lag time. As the amount of PEO was increased in the outer layer the drug released was delayed. The drug content of all the CCT was >99%. The FTIR studies showed no interaction throughout the process of development. Formulations of F7 and of P7 were considered optimized formulations since they yielded a predetermined lag time of 6h before burst release. Hence, these formulations can be exploited to achieve chronotherapeutic drug delivery systems of Torsemide for the treatment of hypertension at the time the patient needs it.

scholarly journals APPLICATION OF THE NEW OROSLIPPERY TECHNOLOGY IN THE PREPARATION OF ENTERIC SLIPPERY COATED TABLET OF NAPROXEN

2017 ◽  
Vol 9 (6) ◽  
pp. 198
Author(s):  
Nidhal K. Maraie ◽  
Anas T. Alhamdany ◽  
Zainab H, Mahdi
Keyword(s):  
Physical Property ◽  
Disintegration Time ◽  
Weight Variation ◽  
Enteric Polymer ◽  
Swallowing Difficulties ◽  
The Common ◽  
Enteric Coated ◽  
Core Tablet ◽  
Optimal Formula

Objective: The aim of this study was to formulate enteric coated oroslippery tablets (OSTs) of naproxen to overcome the common problems of stomach irritation and swallowing difficulties which accompanied the administration of naproxen tablets.Methods: Different formulas of enteric slippery tablets were prepared by direct compression method. Various parameters were investigated like the effect of eudragit L-100 (eud.) concentration (as an enteric polymer), coating level and effect of different concentrations of croscarmellose sodium CCS (as super disintegrant) on the physical properties. Finally, in an in vitro disintegration and release study was carried out.Results: The enteric slippery optimal formula (F8) was selected to consist of double coat (17.5% eudragit (eud.)) with core tablet containing (6% CCS). It was found that this optimal formula having an acceptable physical property (friability, hardness, thickness and weight variation). Besides, the best acid resistant potential represented by the protection of the OSTs for 2 h in 0.1 N HCl without any sign of disintegration and drug release. Moreover, it was found that (F8) has a disintegration time equal to (8±1.36 min) and release of 80% (20±0.18 min) in phosphate buffer pH 6.8.Conclusion: The result revealed the successful preparation of naproxen tablets using enteric slippery coating that can be easily swallowed and prevent direct irritation of the stomach with acceptable tablet weight.

scholarly journals Optimisation andIn VivoEvaluation of Pectin Based Drug Delivery System Containing Curcumin for Colon

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Kishor Butte ◽  
Munira Momin ◽  
Hemant Deshmukh
Keyword(s):  
Drug Release ◽  
Inclusion Complex ◽  
Antioxidant Properties ◽  
The Core ◽  
Eudragit S100 ◽  
Human Volunteers ◽  
Full Factorial ◽  
Core Tablet ◽  
Polymer Ratio

The higher incidences of side effects of existing drugs have shifted researchers and clinicians to explore the dietary phytoconstituents for its therapeutic potentials. The present study is based on compression coated curcumin tablet for the colon. Curcumin has anti-inflammatory and antioxidant properties. Curcumin presents a bioavailability problem due to poor solubility. An inclusion complex was formed with hydroxypropyl-β-cyclodextrin to enhance the solubility. In this study, the core tablet of curcumin inclusion complex was compressed between the layers of polymer blend of pectin and Eudragit S100. The 32full factorial design was utilised for optimization of the formulation. The polymer ratio (X1) and coat thickness (X2) presented significant effects on the selected responses, i.e., percent drug release after 4 hours (Y240) and difference in percent drug release between 4th and 6th hour (Ydiff) in presence of pectinase enzyme. The results revealed that higher coat weight (600 mg) and higher level of pectin ratio (70% w/w) protected the curcumin tablet till ascending colon. Thein vivostudies by roentgenography method using human volunteers supported these observations. Hence, it can be concluded that the combination of pectin and Eudrgit S100 makes the system biodegradable and pH dependent for targeting the drug to the colon.

scholarly journals Optimization Studies on Compression Coated Floating-Pulsatile Drug Delivery of Bisoprolol

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Swati C. Jagdale ◽  
Nilesh A. Bari ◽  
Bhanudas S. Kuchekar ◽  
Aniruddha R. Chabukswar
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Active Ingredient ◽  
Dosage Form ◽  
Release Kinetics ◽  
Lag Phase ◽  
Burst Release ◽  
Release Formulation ◽  
Pulsatile Drug Delivery ◽  
Core Tablet

The purpose of the present work was to design and optimize compression coated floating pulsatile drug delivery systems of bisoprolol. Floating pulsatile concept was applied to increase the gastric residence of the dosage form having lag phase followed by a burst release. The prepared system consisted of two parts: a core tablet containing the active ingredient and an erodible outer shell with gas generating agent. The rapid release core tablet (RRCT) was prepared by using superdisintegrants with active ingredient. Press coating of optimized RRCT was done by polymer. A 32full factorial design was used for optimization. The amount of Polyox WSR205 and Polyox WSR N12K was selected as independent variables. Lag period, drug release, and swelling index were selected as dependent variables. Floating pulsatile release formulation (FPRT) F13 at level 0 (55 mg) for Polyox WSR205 and level +1 (65 mg) for Polyox WSR N12K showed lag time of 4 h with >90% drug release. The data were statistically analyzed using ANOVA, andP<0.05was statistically significant. Release kinetics of the optimized formulation best fitted the zero order model.In vivostudy confirms burst effect at 4 h in indicating the optimization of the dosage form.

Sign in / Sign up

Export Citation Format

Share Document