scholarly journals Handling Uncertainty and Sensitivity of ERA Acute Towards Input Parameters

2021 ◽  
pp. 87-107
Author(s):  
Cathrine Stephansen ◽  
Anders Bjørgesæter ◽  
Odd Willy Brude ◽  
Ute Brönner ◽  
Tonje Waterloo Rogstad ◽  
...  
Keyword(s):  
Scoring System ◽  
Deterministic Model ◽  
Uncertainty Evaluation ◽  
Sensitivity Testing ◽  
Input Parameters ◽  
Set Up ◽  
The Individual ◽  
Parameter Values ◽  
True Values ◽  
Range Of Values

AbstractUncertainty evaluation and sensitivity testing of the functions and parameters used in ERA Acute serve two functions. ERA Acute is a deterministic model which is sensitive to the range of values used for the parameters. Parameters have inherent uncertainties as to what their true values are, and functions may have varying strength of knowledge. The individual functions were tested with respect to their sensitivity towards variation of the parameter values using both deterministic and stochastic testing. Based on the testing, an uncertainty scoring system was used to identify and prioritize the most important parameters for reducing uncertainty. Recommendations for handling the uncertainty and securing comparability in spite of uncertainty were set up as a conclusion of the studies.

Patient Scheduling — (Bibliography)

1977 ◽  
Vol 16 (02) ◽  
pp. 112-115 ◽  
Author(s):  
C. O. Köhler ◽  
G. Wagner ◽  
U. Wolber
Keyword(s):  
Information Processing ◽  
Medical Care ◽  
Medical Informatics ◽  
Relevant Literature ◽  
Patient Scheduling ◽  
Individual Scientist ◽  
Set Up ◽  
The Individual ◽  
New Literature ◽  
Current Systems

The entire field of information processing in medicine is today already spread out and branched to such an extent that it is no longer possible to set up a survey on relevant literature as a whole. But even in narrow parts of medical informatics it is hardly possible for the individual scientist to keep up to date with new literature. Strictly defined special bibliographies on certain topics are most helpful.In our days, problems of optimal patient scheduling and exploitation of resources are gaining more and more importance. Scientists are working on the solution of these problems in many places.The bibliography on »Patient Scheduling« presented here contains but a few basic theoretical papers on the problem of waiting queues which are of importance in the area of medical care. Most of the papers cited are concerned with practical approaches to a solution and describe current systems in medicine.In listing the literature, we were assisted by Mrs. Wieland, Mr. Dusberger and Mr. Henn, in data acquisition and computer handling by Mrs. Gieß and Mr. Schlaefer. We wish to thank all those mentioned for their assistance.

AN IMPROVED METHOD FOR THE ASSAY OF PROGESTERONE BY COMPETITIVE PROTEIN BINDING

1970 ◽  
Vol 63 (2) ◽  
pp. 225-241 ◽  
Author(s):  
B. D. Reeves ◽  
M. L. A. de Souza ◽  
I. E. Thompson ◽  
E. Diczfalusy
Keyword(s):  
Protein Binding ◽  
Binding Sites ◽  
Entire Range ◽  
Improved Method ◽  
Plasma Progesterone ◽  
Extraction And Purification ◽  
Corticosteroid Binding Globulin ◽  
Competitive Protein Binding ◽  
The Individual ◽  
Range Of Values

ABSTRACT An improved method for the assay of plasma progesterone by competitive protein binding is described. The improvement is based upon rigorous control of the variables, the compensation for and standardisation of interfering factors inherent in the method and the use of a human corticosteroid binding globulin, that meets the requirements for sensitivity at levels of 1.0 ng of progesterone and below. The assessment of the reliability of the individual steps in the method as well as that of the complete method is presented. The sensitivity of the method is around 0.2 ng progesterone per ml plasma. Accuracy was measured by adding progesterone in amounts ranging from 0.0 to 1.0 ng to 1.0 ml plasma. There was a linear relationship between the progesterone added and recovered throughout the entire range of values, with a coefficient of correlation (r) of 0.94. Of 52 related steroids tested, none was found which would remain associated with progesterone following extraction and purification and which would also compete with progesterone for binding sites.

scholarly journals Nudge Versus Boost: Agency Dynamics Under Libertarian Paternalism

2019 ◽  
Vol 130 (629) ◽  
pp. 1384-1415 ◽  
Author(s):  
Ralph Hertwig ◽  
Michael D Ryall
Keyword(s):  
Cognitive Biases ◽  
Policy Implications ◽  
Best Interests ◽  
Libertarian Paternalism ◽  
The Future ◽  
Set Up ◽  
The Individual

ABSTRACT Thaler and Sunstein (2008) advance the concept of ‘nudge’ policies—non-regulatory and non-fiscal mechanisms designed to enlist people's cognitive biases or motivational deficits so as to guide their behaviour in a desired direction. A core assumption of this approach is that policymakers make artful use of people's cognitive biases and motivational deficits in ways that serve the ultimate interests of the nudged individual. We analyse a model of dynamic policymaking in which the policymaker's preferences are not always aligned with those of the individual. One novelty of our set-up is that the policymaker has the option to implement a ‘boost’ policy, equipping the individual with the competence to overcome the nudge-enabling bias once and for all. Our main result identifies conditions under which the policymaker chooses not to boost in order to preserve the option of using the nudge (and its associated bias) in the future—even though boosting is in the immediate best interests of both the policymaker and the individual. We extend our analysis to situations in which the policymaker can be removed (e.g., through an election) and in which the policymaker is similarly prone to bias. We conclude with a discussion of some policy implications of these findings.

scholarly journals Theorizing Teacher Responsibility in an Age of Neoliberal Accountability

2019 ◽  
Vol 1 (1) ◽  
pp. 179-195 ◽  
Author(s):  
Tina Besley
Keyword(s):  
Homo Economicus ◽  
Teacher Responsibility ◽  
Keynesian Economics ◽  
The Great Depression ◽  
Market Rationality ◽  
The Subject ◽  
Neoliberal Policies ◽  
Set Up ◽  
The Individual ◽  
The Welfare State

This article explores concepts of teacher responsibility, accountability, being in loco parentis, and responsibilization as many advanced capitalist societies have dropped policies and practices that were set up in the mid 19th century after the Great Depression in the welfare state under Keynesian economics. Since the early 1980s most of these states have adopted neoliberal policies and market rationality for all aspects of social policy including education. Under neoliberalism, the subject theorised by Homo economicus, is one that is theorised as a rational autonomous individual, with its responsibilized behavior underpinning much of how not only teachers but students now are compleed to behace and perform. These have resulted in major shifts in attitudes to professionalism of teachers, in responsibilising individuals and so have impacted on subjectivity as the state has pulled back from all manner of social provision and has responsibilized the individual to be a consumer-citizen, a prudential and entrepreneurial self even in terms of education. The upshot is increasing use of audits, checklists and accountability regimes for teachers who are becoming increasingly a de-professionalised in a low-trust managerialist environment with students as consumers.

scholarly journals An enhanced set of displacement parameter restraints in CRYSTALS

2018 ◽  
Vol 51 (4) ◽  
pp. 1059-1068 ◽  
Author(s):  
Pascal Parois ◽  
James Arnold ◽  
Richard Cooper
Keyword(s):  
Structural Model ◽  
Rigid Bodies ◽  
Model Parameters ◽  
Coordinate Systems ◽  
Principal Axes ◽  
Anisotropic Displacement Parameters ◽  
Set Up ◽  
Meaningful Relationships ◽  
Parameter Values ◽  
Total Model

Crystallographic restraints are widely used during refinement of small-molecule and macromolecular crystal structures. They can be especially useful for introducing additional observations and information into structure refinements against low-quality or low-resolution data (e.g. data obtained at high pressure) or to retain physically meaningful parameter values in disordered or unstable refinements. However, despite the fact that the anisotropic displacement parameters (ADPs) often constitute more than half of the total model parameters determined in a structure analysis, there are relatively few useful restraints for them, examples being Hirshfeld rigid-bond restraints, direct equivalence of parameters and SHELXL RIGU-type restraints. Conversely, geometric parameters can be subject to a multitude of restraints (e.g. absolute or relative distance, angle, planarity, chiral volume, and geometric similarity). This article presents a series of new ADP restraints implemented in CRYSTALS [Parois, Cooper & Thompson (2015), Chem. Cent. J. 9, 30] to give more control over ADPs by restraining, in a variety of ways, the directions and magnitudes of the principal axes of the ellipsoids in locally defined coordinate systems. The use of these new ADPs results in more realistic models, as well as a better user experience, through restraints that are more efficient and faster to set up. The use of these restraints is recommended to preserve physically meaningful relationships between displacement parameters in a structural model for rigid bodies, rotationally disordered groups and low-completeness data.

Consistency of Individual Patterns of Autokinetic Direction

1966 ◽  
Vol 23 (3_suppl) ◽  
pp. 1119-1123 ◽  
Author(s):  
Douglas G. Pearce
Keyword(s):  
Directional Dominance ◽  
Direction Change ◽  
Coefficient Of Concordance ◽  
The Individual ◽  
Range Of Values

Four Ss continuously reported the direction of autokinetic movement during 20 10-min. sessions. Individual patterns of directional dominance and change in direction over the 20 sessions were assessed by means of the Kendall coefficient of concordance. Individual patterns of directional dominance were consistent; the range of values of W for the four Ss was from 0.619 to 0.791. The individual patterns of direction change were generally less consistent; the range of W was from 0.242 to 0.704.

Motion of slender bodies in unsteady Stokes flow

2011 ◽  
Vol 688 ◽  
pp. 66-87 ◽  
Author(s):  
Efrath Barta
Keyword(s):  
Stokes Flow ◽  
Slenderness Ratio ◽  
Creeping Flow ◽  
Slender Body Theory ◽  
Wide Range ◽  
Unsteady Stokes Flow ◽  
Slender Bodies ◽  
Set Up ◽  
Micro Organisms ◽  
Parameter Values

AbstractThe flow regime in the vicinity of oscillatory slender bodies, either an isolated one or a row of many bodies, immersed in viscous fluid (i.e. under creeping flow conditions) is studied. Applying the slender-body theory by distributing proper singularities on the bodies’ major axes yields reasonably accurate and easily computed solutions. The effect of the oscillations is revealed by comparisons with known Stokes flow solutions and is found to be most significant for motion along the normal direction. Streamline patterns associated with motion of a single body are characterized by formation and evolution of eddies. The motion of adjacent bodies results, with a reduction or an increase of the drag force exerted by each body depending on the direction of motion and the specific geometrical set-up. This dependence is demonstrated by parametric results for frequency of oscillations, number of bodies, their slenderness ratio and the spacing between them. Our method, being valid for a wide range of parameter values and for densely packed arrays of rods, enables simulation of realistic flapping of bristled wings of some tiny insects and of locomotion of flagella and ciliated micro-organisms, and might serve as an efficient tool in the design of minuscule vehicles. Its potency is demonstrated by a solution for the flapping of thrips.

Tuners review: How crucial are set-up values to find effective parameter values?

2018 ◽  
Vol 76 ◽  
pp. 108-118 ◽  
Author(s):  
Elizabeth Montero ◽  
María-Cristina Riff ◽  
Nicolás Rojas-Morales
Keyword(s):  
Effective Parameter ◽  
Set Up ◽  
Parameter Values

scholarly journals Reducing parametric uncertainty in limit-cycle oscillation computational models

2017 ◽  
Vol 121 (1241) ◽  
pp. 940-969 ◽  
Author(s):  
R. Hayes ◽  
R. Dwight ◽  
S. Marques
Keyword(s):  
Limit Cycle ◽  
Computational Models ◽  
Structural Parameters ◽  
Parametric Uncertainty ◽  
Limit Cycle Oscillation ◽  
Posterior Distributions ◽  
Input Parameters ◽  
Data Points ◽  
Cycle Oscillation ◽  
True Values

ABSTRACTThe assimilation of discrete data points with model predictions can be used to achieve a reduction in the uncertainty of the model input parameters, which generate accurate predictions. The problem investigated here involves the prediction of limit-cycle oscillations using a High-Dimensional Harmonic Balance (HDHB) method. The efficiency of the HDHB method is exploited to enable calibration of structural input parameters using a Bayesian inference technique. Markov-chain Monte Carlo is employed to sample the posterior distributions. Parameter estimation is carried out on a pitch/plunge aerofoil and two Goland wing configurations. In all cases, significant refinement was achieved in the distribution of possible structural parameters allowing better predictions of their true deterministic values. Additionally, a comparison of two approaches to extract the true values from the posterior distributions is presented.

scholarly journals MEMLS3&a: Microwave Emission Model of Layered Snowpacks adapted to include backscattering

2015 ◽  
Vol 8 (8) ◽  
pp. 2611-2626 ◽  
Author(s):  
M. Proksch ◽  
C. Mätzler ◽  
A. Wiesmann ◽  
J. Lemmetyinen ◽  
M. Schwank ◽  
...  
Keyword(s):  
Microwave Remote Sensing ◽  
Horizontal Layer ◽  
Microwave Emission ◽  
Emission Model ◽  
Input Parameters ◽  
Fitting Procedures ◽  
Splitting Parameter ◽  
Set Up ◽  
Passive Measurements ◽  
Active Microwave Remote Sensing

Abstract. The Microwave Emission Model of Layered Snowpacks (MEMLS) was originally developed for microwave emissions of snowpacks in the frequency range 5–100 GHz. It is based on six-flux theory to describe radiative transfer in snow including absorption, multiple volume scattering, radiation trapping due to internal reflection and a combination of coherent and incoherent superposition of reflections between horizontal layer interfaces. Here we introduce MEMLS3&a, an extension of MEMLS, which includes a backscatter model for active microwave remote sensing of snow. The reflectivity is decomposed into diffuse and specular components. Slight undulations of the snow surface are taken into account. The treatment of like- and cross-polarization is accomplished by an empirical splitting parameter q. MEMLS3&a (as well as MEMLS) is set up in a way that snow input parameters can be derived by objective measurement methods which avoid fitting procedures of the scattering efficiency of snow, required by several other models. For the validation of the model we have used a combination of active and passive measurements from the NoSREx (Nordic Snow Radar Experiment) campaign in Sodankylä, Finland. We find a reasonable agreement between the measurements and simulations, subject to uncertainties in hitherto unmeasured input parameters of the backscatter model. The model is written in Matlab and the code is publicly available for download through the following website: http://www.iapmw.unibe.ch/research/projects/snowtools/memls.html.

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